AC T05113
XX
ID T05113
XX
DT 15.05.2002 (created); cch.
DT 30.07.2014 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA PML-8
XX
SY MYL; PML; PML-3; probable transcription factor PML; promyelocytic leukemia; promyelocytic leukemia protein isoform 3; RNF71; TRIM19; tripartite motif protein 19.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G013657 PML; HGNC: PML.
XX
SZ 824 AA; 90.2 kDa (cDNA) (calc.).
XX
SQ MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
SQ QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
SQ QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
SQ TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
SQ DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
SQ VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
SQ QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
SQ EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
SQ QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
SQ NSNHVASGAGEAEERVVVISSSEDSDAENSCMEPMETAEPQSSPAHSSPAHSSPVQSLLR
SQ AQGASSLPCGTYHPPAWPPHQPAEQAATPDAEPHSEPPDHQERPAVHRGIRYLLYRAQRA
SQ IRLRHALRLHPQLHRAPIRTWSPHVVQASTPAITGPLNHPANAQEHPAQLQRGISPPHRI
SQ RGAVRSRSRSLRGSSHLSQWLNNFFALPFSSMASQLDMSSVVGAGEGRAQTLGAVVPPGD
SQ SVRGSMEASQVQVPLEASPITFPPPCAPERPPISPVPGARQAGL
XX
SC Swiss-Prot#P29590-3
XX
IN T00671 p53; human, Homo sapiens.
IN T14535 TBX2; Mammalia.
XX
DR TRANSPATH: MO000031070.
DR EMBL: M79464; HSPML3.
DR UniProtKB: P29590-3;
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RN [1]; RE0017784.
RX PUBMED: 1720570.
RA Goddard A. D., Borrow J., Freemont P. S., Solomon E.
RT Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.
RL Science 254:1371-1374 (1991).
RN [2]; RE0020915.
RX PUBMED: 11740489.
RA Hofmann T. G., Moeller A., Sirma H., Zentgraf H., Taya Y., Droege W., Will H., Schmitz M. L.
RT Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
RL Nat. Cell Biol. 4:1-10 (2002).
RN [3]; RE0020922.
RX PUBMED: 11780126.
RA D'Orazi G., Cecchinelli B., Bruno T., Manni I., Higashimoto Y., Saito S., Gostissa M., Coen S., Marchetti A., Del Sal G., Piaggio G., Fanciulli M., Appella E., Soddu S.
RT Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
RL Nat. Cell Biol. 4:11-19 (2002).
RN [4]; RE0048465.
RX PUBMED: 15707587.
RA Hakli M., Karvonen U., Janne O. A., Palvimo J. J.
RT SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies.
RL Exp. Cell Res. 304:224-233 (2005).
RN [5]; RE0020919.
RX PUBMED: 10681541.
RA Graves P. R., Yu L., Schwarz J. K., Gales J., Sausville E. A., O'Connor P. M., Piwnica-Worms H.
RT The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
RL J. Biol. Chem. 275:5600-5605 (2000).
XX
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