AC T05128
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ID T05128
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DT 24.05.2002 (created); sth.
DT 03.06.2015 (updated); msr.
CO Copyright (C), QIAGEN.
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FA IRF-3
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SY INTERFERON REGULATORY FACTOR 3; IRF-3; irf3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004377 Irf3.
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CL C0022; trp; 3.5.3.0.3.
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IN T10351 RORgamma; mouse, Mus musculus.
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MX M02767 V$IRF3_05.
MX M02871 V$IRF3_06.
MX M01279 V$IRF3_Q3.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R25876.
BS R10369.
BS R04222.
BS R26722.
BS R00946.
BS R33317.
BS R64632.
BS R72439.
BS R25873.
BS R74073.
BS R68044.
BS R26289.
BS R26292.
XX
DR TRANSPATH: MO000032972.
DR TRANSCOMPEL: C00337.
DR UniProtKB: P70671;
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RN [1]; RE0017844.
RX PUBMED: 9803267.
RA Bellingham J., Gregory-Evans K., Gregory-Evans C. Y.
RT Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
RL Ann. Hum. Genet. 62:231-234 (1998).
RN [2]; RE0052783.
RX PUBMED: 16757566.
RA McGettrick A. F., Brint E. K., Palsson-McDermott E. M., Rowe D. C., Golenbock D. T., Gay N. J., Fitzgerald K. A., O'Neill L. A.
RT Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
RL Proc. Natl. Acad. Sci. USA 103:9196-9201 (2006).
RN [3]; RE0053165.
RX PUBMED: 17878357.
RA Kang Y. J., Kusler B., Otsuka M., Hughes M., Suzuki N., Suzuki S., Yeh W. C., Akira S., Han J., Jones P. P.
RT Calcineurin negatively regulates TLR-mediated activation pathways.
RL J. Immunol. 179:4598-4607 (2007).
RN [4]; RE0053835.
RX PUBMED: 17395780.
RA Wang Y., Chen T., Han C., He D., Liu H., An H., Cai Z., Cao X.
RT Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.
RL Blood 110:962-971 (2007).
RN [5]; RE0054266.
RX PUBMED: 15367631.
RA tenOever B. R., Sharma S., Zou W., Sun Q., Grandvaux N., Julkunen I., Hemmi H., Yamamoto M., Akira S., Yeh W. C., Lin R., Hiscott J.
RT Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
RL J. Virol. 78:10636-10649 (2004).
RN [6]; RE0054898.
RX PUBMED: 17823124.
RA Gatot J. S., Gioia R., Chau T. L., Patrascu F., Warnier M., Close P., Chapelle J. P., Muraille E., Brown K., Siebenlist U., Piette J., Dejardin E., Chariot A.
RT Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
RL J. Biol. Chem. 282:31131-31146 (2007).
RN [7]; RE0055012.
RX PUBMED: 18471880.
RA Dong L. W., Kong X. N., Yan H. X., Yu L. X., Chen L., Yang W., Liu Q., Huang D. D., Wu M. C., Wang H. Y.
RT Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.
RL Mol. Immunol. 45:3025-3035 (2008).
RN [8]; RE0055095.
RX PUBMED: 18818394.
RA Liu X., Yao M., Li N., Wang C., Zheng Y., Cao X.
RT CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages.
RL Blood 112:4961-4970 (2008).
RN [9]; RE0055106.
RX PUBMED: 18635538.
RA Kubota T., Matsuoka M., Chang T. H., Tailor P., Sasaki T., Tashiro M., Kato A., Ozato K.
RT Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression.
RL J. Biol. Chem. 283:25660-25670 (2008).
RN [10]; RE0055204.
RX PUBMED: 12447441.
RA Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., Hoshino K., Takeuchi O., Kobayashi M., Fujita T., Takeda K., Akira S.
RT Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
RL Nature 420:324-329 (2002).
RN [11]; RE0055418.
RX PUBMED: 12766168.
RA Sanzone S., Zeyda M., Saemann M. D., Soncini M., Holter W., Fritsch G., Knapp W., Candotti F., Stulnig T. M., Parolini O.
RT SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.
RL J. Biol. Chem. 278:29593-29599 (2003).
RN [12]; RE0065117.
RX PUBMED: 17056502.
RA Matsui K., Kumagai Y., Kato H., Sato S., Kawagoe T., Uematsu S., Takeuchi O., Akira S.
RT Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
RL J. Immunol. 177:5785-5789 (2006).
RN [13]; RE0065193.
RX PUBMED: 16039576.
RA Kato H., Sato S., Yoneyama M., Yamamoto M., Uematsu S., Matsui K., Tsujimura T., Takeda K., Fujita T., Takeuchi O., Akira S.
RT Cell type-specific involvement of RIG-I in antiviral response.
RL Immunity 23:19-28 (2005).
RN [14]; RE0065206.
RX PUBMED: 18571728.
RA Xu H., An H., Hou J., Han C., Wang P., Yu Y., Cao X.
RT Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
RL Mol. Immunol. 45:3545-3552 (2008).
RN [15]; RE0065238.
RX PUBMED: 18268035.
RA Turer E. E., Tavares R. M., Mortier E., Hitotsumatsu O., Advincula R., Lee B., Shifrin N., Malynn B. A., Ma A.
RT Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.
RL J. Exp. Med. 205:451-464 (2008).
RN [16]; RE0065785.
RX PUBMED: 19479062.
RA Konno H., Yamamoto T., Yamazaki K., Gohda J., Akiyama T., Semba K., Goto H., Kato A., Yujiri T., Imai T., Kawaguchi Y., Su B., Takeuchi O., Akira S., Tsunetsugu-Yokota Y., Inoue J.
RT TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.
RL PLoS ONE 4:e5674 (2009).
RN [17]; RE0067339.
RX PUBMED: 19926846.
RA Saitoh T., Fujita N., Hayashi T., Takahara K., Satoh T., Lee H., Matsunaga K., Kageyama S., Omori H., Noda T., Yamamoto N., Kawai T., Ishii K., Takeuchi O., Yoshimori T., Akira S.
RT Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
RL Proc. Natl. Acad. Sci. USA 106:20842-20846 (2009).
RN [18]; RE0068265.
RX PUBMED: 20083668.
RA Molle C., Goldman M., Goriely S.
RT Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.
RL J. Immunol. 184:1784-1792 (2010).
RN [19]; RE0068560.
RX PUBMED: 18242112.
RA Takahasi K., Yoneyama M., Nishihori T., Hirai R., Kumeta H., Narita R., Gale M J. r., Inagaki F., Fujita T.
RT Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.
RL Mol. Cell 29:428-440 (2008).
RN [20]; RE0068561.
RX PUBMED: 16116171.
RA Yoneyama M., Kikuchi M., Matsumoto K., Imaizumi T., Miyagishi M., Taira K., Foy E., Loo Y. M., Gale M J. r., Akira S., Yonehara S., Kato A., Fujita T.
RT Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
RL J. Immunol. 175:2851-2858 (2005).
RN [21]; RE0068850.
RX PUBMED: 20200270.
RA Hoshino K., Sasaki I., Sugiyama T., Yano T., Yamazaki C., Yasui T., Kikutani H., Kaisho T.
RT Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.
RL J. Immunol. 184:3341-3345 (2010).
RN [22]; RE0069876.
RX PUBMED: 17618271.
RA Takaoka A., Wang Z., Choi M. K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., Ohba Y., Taniguchi T.
RT DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
RL Nature 448:501-505 (2007).
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