AC T05144
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ID T05144
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DT 31.05.2002 (created); sth.
DT 10.12.2014 (updated); sup.
CO Copyright (C), QIAGEN.
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FA IRF-7
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SY Interferon regulatory factor 7; IRF-7; IRF7.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004397 Irf7.
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CL C0022; trp; 3.5.3.0.7.
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MX M00453 V$IRF7_01.
MX M01884 V$IRF7_Q3.
MX M03793 V$IRF7_Q3_01.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R65226.
BS R65228.
BS R65229.
BS R59011.
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DR TRANSPATH: MO000032982.
DR EMBL: U73037;
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RN [1]; RE0051469.
RX PUBMED: 15767370.
RA Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K. J., Kawai T., Takeuchi O., Akira S.
RT Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
RL J. Exp. Med. 201:915-923 (2005).
RN [2]; RE0051557.
RX PUBMED: 15361868.
RA Kawai T., Sato S., Ishii K. J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., Akira S.
RT Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
RL Nat. Immunol. 5:1061-1068 (2004).
RN [3]; RE0064356.
RX PUBMED: 16612387.
RA Hoshino K., Sugiyama T., Matsumoto M., Tanaka T., Saito M., Hemmi H., Ohara O., Akira S., Kaisho T.
RT IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.
RL Nature 440:949-953 (2006).
RN [4]; RE0065700.
RX PUBMED: 18758466.
RA Cao W., Manicassamy S., Tang H., Kasturi S. P., Pirani A., Murthy N., Pulendran B.
RT Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
RL Nat. Immunol. 9:1157-1164 (2008).
RN [5]; RE0069228.
RX PUBMED: 20668674.
RA Higgs R., Lazzari E., Wynne C., Ni Gabhann J., Espinosa A., Wahren-Herlenius M., Jefferies C. A.
RT Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.
RL PLoS ONE 5:e11776 (2010).
RN [6]; RE0069326.
RX PUBMED: 20231379.
RA Gotoh K., Tanaka Y., Nishikimi A., Nakamura R., Yamada H., Maeda N., Ishikawa T., Hoshino K., Uruno T., Cao Q., Higashi S., Kawaguchi Y., Enjoji M., Takayanagi R., Kaisho T., Yoshikai Y., Fukui Y.
RT Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.
RL J. Exp. Med. 207:721-730 (2010).
RN [7]; RE0069876.
RX PUBMED: 17618271.
RA Takaoka A., Wang Z., Choi M. K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., Ohba Y., Taniguchi T.
RT DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
RL Nature 448:501-505 (2007).
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