AC T09116
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ID T09116
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DT 20.07.2006 (created); spi.
DT 08.05.2013 (updated); vad.
CO Copyright (C), QIAGEN.
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FA securin
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SY EAP1; ESP1-associated protein 1; HPTTG; pituitary tumor-transforming 1; pituitary tumor-transforming protein 1; PTTG; PTTG1; securin; tumor transforming protein 1; TUTR1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013651 PTTG1; HGNC: PTTG1.
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SZ 202 AA; 22.0 kDa (calc.).
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SQ MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKAT
SQ RKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPF
SQ NPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQ
SQ SPSSILSTLDVELPPVCCDIDI
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SC translated from EMBL #AF095287
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FT 1 191 
PF04856; Securin sister-chromatid separation inhibito.
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IN T18732 aebp2; human, Homo sapiens.
IN T15300 HMG17; human, Homo sapiens.
IN T18664 NOLA2; human, Homo sapiens.
IN T10643 TBPL1; human, Homo sapiens.
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DR TRANSPATH: MO000083564.
DR EMBL: AF095287;
DR UniProtKB: O95997; PTTG1_HUMAN.
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RN [1]; RE0025241.
RX PUBMED: 12355087.
RA Bernal J. A., Luna R., Espina A., Lazaro I., Ramos-Morales F., Romero F., Arias C., Silva A., Tortolero M., Pintor-Toro J. A.
RT Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.
RL Nat. Genet. 32:306-311 (2002).
RN [2]; RE0031397.
RX PUBMED: 12956947.
RA Vodermaier H. C., Gieffers C., Maurer-Stroh S., Eisenhaber F., Peters J. M.
RT TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
RL Curr. Biol. 13:1459-68 (2003).
RN [3]; RE0035154.
RX PUBMED: 15016801.
RA Kho P. S., Wang Z., Zhuang L., Li Y., Chew J. L., Ng H. H., Liu E. T., Yu Q.
RT p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis.
RL J. Biol. Chem. 279:21183-21192 (2004).
RN [4]; RE0038099.
RX PUBMED: 12194817.
RA Waizenegger I., Gimenez-Abian J., Wernic D., Peters J.
RT Regulation of human separase by securin binding and autocleavage
RL Curr. Biol. 12:1368 (2002).
RN [5]; RE0039232.
RX PUBMED: 11179223.
RA Zur A., Brandeis M.
RT Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis
RL EMBO J. 20:792-801 (2001).
RN [6]; RE0048865.
RX PUBMED: 16868023.
RA Holland A. J., Taylor S. S.
RT Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.
RL J. Cell Sci. 119:3325-3336 (2006).
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