AC T09174
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ID T09174
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DT 02.08.2006 (created); jul.
DT 02.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Pit-1-isoform1
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SY GHF-1; growth hormone factor 1; Pit-1; Pit-1B; pituitary-specific positive transcription factor 1; POU1F1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004568 Pou1f1.
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CL C0007; POU; 3.1.10.1.1.2.
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SZ 291 AA; 32.9 kDa (cDNA) (calc.).
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SQ MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNVMSTATGLHYSVPSCHY
SQ GNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDPAASEFKQELRRKSKLVEE
SQ PIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSF
SQ KNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISVAAKDALERHFGEHSKPS
SQ SQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR
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SC Swiss-Prot#Q00286-1
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FT 124 198 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 124 198 
SM00352; pou.
FT 212 272 
PS50071; HOMEOBOX_2.
FT 212 274 
PS50550; POU_HOMEODOMAIN.
FT 214 276 
SM00389; HOX_1.
FT 215 271 
PF00046; Homeobox domain.
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IN T33673 Ets-1; chick, Gallus gallus.
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MX M01465 V$PIT1_01.
MX M00802 V$PIT1_Q6.
MX M03559 V$PIT1_Q6_01.
MX M00744 V$POU1F1_Q6.
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DR TRANSPATH: MO000084116.
DR EMBL: D12885; MMPIT1R.
DR EMBL: D12886; MMPIT1D.
DR UniProtKB: Q00286-1;
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RN [1]; RE0002474.
RX PUBMED: 1901656.
RA Steinfelder H. J., Hauser P., Nakayama Y., Radovick S., McClaskey J. H., Taylor T., Weintraub B. D., Wondisford F. E.
RT Thyrotropin-releasing hormone regulation of human TSHB expression: Role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element
RL Proc. Natl. Acad. Sci. USA 88:3130-3134 (1991).
RN [2]; RE0004422.
RX PUBMED: 1977085.
RA Li S., Crenshaw III E. B., Rawson E. J., Simmons D. M., Swanson L. W., Rosenfeld M. G.
RT Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
RL Nature 347:528-533 (1990).
RN [3]; RE0004423.
RX PUBMED: 8166682.
RA Jehn B., Chicaiza G., Martin F., Jaggi R.
RT Isolation of three novel POU-domain containing cDNA clones from lactating mouse mammary gland
RL Biochem. Biophys. Res. Commun. 200:156-162 (1994).
RN [4]; RE0004425.
RX PUBMED: 1690079.
RA Dolle P., Castrillo J.-L., Theill L. E., Deerinck T., Ellisman M., Karin M.
RT Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity
RL Cell 60:809-820 (1990).
RN [5]; RE0004426.
RX PUBMED: 1981057.
RA Camper S. A., Saunders T. L., Katz R. W., Reeves R. H.
RT The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation
RL Genomics 8:586-590 (1990).
RN [6]; RE0004429.
RX PUBMED: 1677216.
RA Castrillo J.-L., Theill L. E., Karin M.
RT Function of the homeodomain protein GHF1 in pituitary cell proliferation
RL Science 253:197-199 (1991).
RN [7]; RE0004437.
RX PUBMED: 1310694.
RA Steinfelder H. J., Radovick S., Mroczynski M. A., Hauser P., McClaskey J. H., Weintraub B. D., Wondisford F. E.
RT Role of a pituitary-specific transcription factor (Pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-b subunit gene expression
RL J. Clin. Invest. 89:409-419 (1992).
RN [8]; RE0017919.
RX PUBMED: 10652292.
RA Bradford A. P., Brodsky K. S., Diamond S. E., Kuhn L. C., Liu Y., Gutierrez-Hartmann A.
RT The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter.
RL J. Biol. Chem. 275:3100-3106 (2000).
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