AC T09199
XX
ID T09199
XX
DT 08.08.2006 (created); lyn.
DT 02.06.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA STAT5A-isoform1
XX
SY Signal Transducer and Activator of Transcription 1; signal transducer and activator of transcription 5a; STAT5; STAT5A.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002606 STAT5A; HGNC: STAT5A.
XX
CL C0039; STAT.
XX
SZ 794 AA; 90.6 kDa (calc.).
XX
SQ MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
SQ LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
SQ REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
SQ RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
SQ RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
SQ QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
SQ NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
SQ LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
SQ TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SQ SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
SQ QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
SQ GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
SQ MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
SQ PPAGLFTSARGSLS
XX
SC translated from EMBL #L41142
XX
FT 2 126 
PF02865; STAT protein, protein interaction domain.
FT 138 330 
PF01017; STAT protein, all-alpha domain.
FT 146 481 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 332 583 
PF02864; STAT protein, DNA binding domain.
FT 587 700 
SM00252; SH2_5.
FT 589 670 
PF00017; SH2 domain.
FT 589 686 
PS50001; SH2.
XX
IN T34682 Hp1-alpha; human, Homo sapiens.
XX
MX M00457 V$STAT5A_01.
MX M00460 V$STAT5A_02.
MX M00493 V$STAT5A_03.
MX M00499 V$STAT5A_04.
MX M07311 V$STAT5A_Q4.
MX M01890 V$STAT5A_Q6.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R10477.
BS R10478.
BS R10479.
BS R10480.
BS R10481.
BS R10482.
BS R10483.
BS R10484.
BS R10485.
BS R10486.
BS R11962.
BS R11963.
BS R11964.
BS R11965.
BS R11966.
BS R11967.
BS R11968.
BS R11969.
BS R11970.
BS R11971.
BS R10487.
BS R10488.
BS R10489.
BS R10490.
BS R10491.
BS R10492.
BS R10493.
BS R10494.
BS R10495.
BS R10496.
BS R10497.
BS R10498.
BS R10499.
BS R10500.
BS R10501.
BS R10502.
BS R10503.
BS R10504.
BS R10505.
BS R10506.
BS R10507.
BS R10508.
BS R10509.
BS R10556.
BS R10557.
BS R10558.
BS R10559.
BS R10560.
BS R10561.
BS R10562.
BS R10563.
BS R10564.
BS R10565.
BS R10566.
BS R10567.
BS R10568.
BS R10569.
BS R10570.
BS R10571.
BS R10572.
BS R10573.
BS R10574.
BS R10575.
BS R10576.
BS R10577.
BS R10578.
BS R10579.
BS R10580.
BS R10581.
BS R10582.
BS R10583.
BS R10584.
BS R10585.
BS R10586.
BS R10587.
BS R10588.
BS R10589.
BS R10590.
BS R10591.
BS R10592.
BS R11933.
BS R11934.
BS R11935.
BS R11936.
BS R11937.
BS R11938.
BS R11939.
BS R11940.
BS R11941.
BS R11942.
BS R11943.
BS R11944.
BS R11945.
BS R11946.
BS R11947.
BS R11948.
BS R11949.
BS R11950.
BS R11951.
BS R11952.
BS R11953.
BS R11954.
BS R11955.
BS R11956.
BS R11957.
BS R11958.
BS R11959.
BS R11960.
BS R11961.
BS R14311.
BS R11115.
BS R22320.
BS R11183.
BS R11154.
BS R11155.
BS R11156.
BS R11157.
BS R04252.
XX
DR TRANSPATH: MO000084523.
DR EMBL: L41142;
DR EMBL: U43185;
DR UniProtKB: P42229;
XX
RN [1]; RE0016782.
RX PUBMED: 10594041.
RA Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J.
RT DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.
RL Mol. Cell. Biol. 20:389-401 (2000).
RN [2]; RE0019120.
RX PUBMED: 7719937.
RA HOU J., SCHINDLER U., HENZEL W.J., WONG S.C., MCKNIGHT S.L.
RT Identification and purification of human Stat proteins activated in response to interleukin-2.
RL Immunity 2:321-329 (1995).
RN [3]; RE0023467.
RX PUBMED: 9742102.
RA Verdier F., Rabionet R., Gouilleux F., Beisenherz-Huss C., Varlet P., Muller O., Mayeux P., Lacombe C., Gisselbrecht S., Chretien S.
RT A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.
RL Mol. Cell. Biol. 18:5852-5860 (1998).
RN [4]; RE0024933.
RX PUBMED: 14645506.
RA Magne S., Caron S., Charon M., Rouyez M. C., Dusanter-Fourt I.
RT STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.
RL Mol. Cell. Biol. 23:8934-8945 (2003).
RN [5]; RE0049465.
RX PUBMED: 16273093.
RA Jones R. B., Gordus A., Krall J. A., MacBeath G.
RT A quantitative protein interaction network for the ErbB receptors using protein microarrays.
RL Nature 439:168-174 (2006).
RN [6]; RE0051994.
RX PUBMED: 11981045.
RA Nevalainen M. T., Xie J., Bubendorf L., Wagner K. U., Rui H.
RT Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium.
RL Mol. Endocrinol. 16:1108-1124 (2002).
RN [7]; RE0064848.
RX PUBMED: 18071309.
RA Tao W. J., Lin H., Sun T., Samanta A. K., Arlinghaus R.
RT BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.
RL Oncogene 27:3194-3200 (2008).
RN [8]; RE0065547.
RX PUBMED: 18768389.
RA Didichenko S. A., Spiegl N., Brunner T., Dahinden C. A.
RT IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils.
RL Blood 112:3949-3958 (2008).
XX
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