AC T15759
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ID T15759
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DT 24.03.2009 (created); din.
DT 11.06.2009 (updated); bjo.
CO Copyright (C), QIAGEN.
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FA Six-3
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SY HPE2; hSix-3; hSix3; Sine oculis homeobox homolog 3; SIX homeobox 3; Six3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005716 SIX3; HGNC: Six3.
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CL C0006; homeo.
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SZ 332 AA; 35.5 kDa (cDNA) (calc.).
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SQ MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAG
SQ GAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPG
SQ ACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKL
SQ RGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELA
SQ QATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTA
SQ ASPTTSVSSLTERADTGTSILSVTSSDSECDV
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SC translated from EMBL #AJ012611
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FT 88 207 
PS50553; SIX_DOMAIN.
FT 204 264 
PS50071; HOMEOBOX_2.
FT 206 264 
PS50554; SIX_HOMEODOMAIN.
FT 207 263 
PF00046; Homeobox domain.
FT 207 268 
SM00389; HOX_1.
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IN T15532 NOR1; human, Homo sapiens.
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MX M01358 V$SIX3_01.
MX M07428 V$SIX3_Q6.
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BS R13561.
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DR TRANSPATH: MO000155416.
DR EMBL: AJ012611;
DR UniProtKB: O95343;
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RN [1]; RE0014457.
RX PUBMED: 10369266.
RA Wallis D. E., Roessler E., Hehr U., Nanni L., Wiltshire T., Richieri-Costa A., Gillessen-Kaesbach G., Zackai E. H., Rommens J., Muenke M.
RT Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly
RL Nat. Genet. 22:196-198 (1999).
RN [2]; RE0014529.
RX PUBMED: 10381573.
RA Seo H. C., Curtiss J., Mlodzik M., Fjose A.
RT Six class homeobox genes in drosophila belong to three distinct families and are involved in head development
RL Mech. Dev. 83:127-139 (1999).
RN [3]; RE0016142.
RX PUBMED: 11039582.
RA Pasquier L., Dubourg C., Blayau M., Lazaro L., Le Marec B., David V., Odent S.
RT A new mutation in the six-domain of SIX3 gene causes holoprosencephaly.
RL Eur. J. Hum. Genet. 8:797-800 (2000).
RN [4]; RE0023150.
RX PUBMED: 11139622.
RA Lengler J., Krausz E., Tomarev S., Prescott A., Quinlan R. A., Graw J.
RT Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.
RL Nucleic Acids Res. 29:515-526 (2001).
RN [5]; RE0063045.
RX PUBMED: 12543801.
RA Laflamme C., Filion C., Bridge J. A., Ladanyi M., Goldring M. B., Labelle Y.
RT The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas.
RL Cancer Res. 63:449-454 (2003).
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