AC T17245
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ID T17245
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DT 29.10.2003 (created); cch.
DT 20.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA STAT1{p}
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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IN T15268 MBD1; human, Homo sapiens.
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BS R38394.
BS R64649.
BS R29804.
BS R35414.
BS R56080.
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DR TRANSPATH: MO000037685.
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RN [1]; RE0023366.
RX PUBMED: 10779328.
RA Saharinen P., Takaluoma K., Silvennoinen O.
RT Regulation of the Jak2 tyrosine kinase by its pseudokinase domain.
RL Mol. Cell. Biol. 20:3387-3395 (2000).
RN [2]; RE0035773.
RX PUBMED: 9353320.
RA Koshelnick Y., Ehart M., Hufnagl P., Heinrich P. C., Binder B. R.
RT Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598.
RL J. Biol. Chem. 272:28563-28567 (1997).
RN [3]; RE0047126.
RX PUBMED: 11777960.
RA Sutherland C. L., Chalupny N. J., Schooley K., VandenBos T., Kubin M., Cosman D.
RT UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
RL J. Immunol. 168:671-9 (2002).
RN [4]; RE0049934.
RX PUBMED: 15825084.
RA Lin W., Choe W. H., Hiasa Y., Kamegaya Y., Blackard J. T., Schmidt E. V., Chung R. T.
RT Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.
RL Gastroenterology 128:1034-1041 (2005).
RN [5]; RE0055012.
RX PUBMED: 18471880.
RA Dong L. W., Kong X. N., Yan H. X., Yu L. X., Chen L., Yang W., Liu Q., Huang D. D., Wu M. C., Wang H. Y.
RT Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.
RL Mol. Immunol. 45:3025-3035 (2008).
RN [6]; RE0064130.
RX PUBMED: 18362173.
RA Flex E., Petrangeli V., Stella L., Chiaretti S., Hornakova T., Knoops L., Ariola C., Fodale V., Clappier E., Paoloni F., Martinelli S., Fragale A., Sanchez M., Tavolaro S., Messina M., Cazzaniga G., Camera A., Pizzolo G., Tornesello A., Vignetti M., Battistini A., Cave H., Gelb B. D., Renauld J. C., Biondi A., Constantinescu S. N., Foa R., Tartaglia M.
RT Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia.
RL J. Exp. Med. 205:751-758 (2008).
RN [7]; RE0064666.
RX PUBMED: 19592490.
RA Wort S. J., Ito M., Chou P. C., Mc Master S. K., Badiger R., Jazrawi E., de Souza P., Evans T. W., Mitchell J. A., Pinhu L., Ito K., Adcock I. M.
RT Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites.
RL J. Biol. Chem. 284:24297-24305 (2009).
RN [8]; RE0064765.
RX PUBMED: 17653195.
RA Malathi K., Dong B., Gale M J. r., Silverman R. H.
RT Small self-RNA generated by RNase L amplifies antiviral innate immunity.
RL Nature 448:816-819 (2007).
RN [9]; RE0064832.
RX PUBMED: 19543380.
RA Delaloye J., Roger T., Steiner-Tardivel Q. G., Le Roy D., Knaup Reymond M., Akira S., Petrilli V., Gomez C. E., Perdiguero B., Tschopp J., Pantaleo G., Esteban M., Calandra T.
RT Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.
RL PLoS Pathog. 5:e1000480 (2009).
RN [10]; RE0064975.
RX PUBMED: 19776010.
RA McGillicuddy F. C., Chiquoine E. H., Hinkle C. C., Kim R. J., Shah R., Roche H. M., Smyth E. M., Reilly M. P.
RT Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.
RL J. Biol. Chem. 284:31936-31944 (2009).
RN [11]; RE0065006.
RX PUBMED: 19074829.
RA McGough J. M., Yang D., Huang S., Georgi D., Hewitt S. M., Rocken C., Tanzer M., Ebert M. P., Liu K.
RT DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.
RL Mol. Cancer Res. 6:1841-1851 (2008).
RN [12]; RE0065158.
RX PUBMED: 18281489.
RA Wang Y., Liu D., Chen P., Koeffler H. P., Tong X., Xie D.
RT Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers.
RL Cancer Res. 68:1136-1143 (2008).
RN [13]; RE0065354.
RX PUBMED: 19404947.
RA Karonitsch T., Feierl E., Steiner C. W., Dalwigk K., Korb A., Binder N., Rapp A., Steiner G., Scheinecker C., Smolen J., Aringer M.
RT Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells.
RL Arthritis Rheum. 60:1463-1471 (2009).
RN [14]; RE0066502.
RX PUBMED: 10352242.
RA Su L., David M.
RT Inhibition of B cell receptor-mediated apoptosis by IFN.
RL J. Immunol. 162:6317-6321 (1999).
RN [15]; RE0068022.
RX PUBMED: 18316378.
RA Jayakumar A., Donovan M. J., Tripathi V., Ramalho-Ortigao M., McDowell M. A.
RT Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells.
RL Infect. Immun. 76:2138-2148 (2008).
RN [16]; RE0069503.
RX PUBMED: 20974963.
RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J.
RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010).
RN [17]; RE0070259.
RX PUBMED: 21076058.
RA Yu R. Y., Gallagher G.
RT A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells.
RL J. Immunol. 185:7302-7308 (2010).
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