AC T30146
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ID T30146
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DT 12.11.2003 (created); cch.
DT 01.10.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA STAT3{pY705}
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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IN T09920 CREB1; Mammalia.
XX
BS R63111.
BS R63122.
BS R63112.
BS R63120.
BS R60025.
BS R60030.
BS R60035.
BS R60038.
BS R29885.
XX
DR TRANSPATH: MO000037848.
DR TRANSCOMPEL: C00469.
XX
RN [1]; RE0012661.
RX PUBMED: 8670868.
RA Nakajima K., Yamanaka Y., Nakae K., Kojima H., Ichiba M., Kiuchi N., Kitaoka T., Fukada T., Hibi M., Hirano T.
RT A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells
RL EMBO J. 15:3651-3658 (1996).
RN [2]; RE0023482.
RX PUBMED: 12244095.
RA Schreiner S. J., Schiavone A. P., Smithgall T. E.
RT Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.
RL J. Biol. Chem. 277:45680-45687 (2002).
RN [3]; RE0031901.
RX PUBMED: 12707269.
RA Plun-Favreau H., Perret D., Diveu C., Froger J., Chevalier S., Lelievre E., Gascan H., Chabbert M.
RT Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor.
RL J. Biol. Chem. 278:27169-79 (2003).
RN [4]; RE0031906.
RX PUBMED: 15012602.
RA Auernhammer C. J., Dorn F., Vlotides G., Hengge S., Kopp F. B., Spoettl G., Cengic N., Engelhardt D., Weber M. M.
RT The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.
RL J. Endocrinol. 180:479-86 (2004).
RN [5]; RE0043173.
RX PUBMED: 9405487.
RA Bjorbaek C., Uotani S., da Silva B., Flier J. S.
RT Divergent signaling capacities of the long and short isoforms of the leptin receptor
RL J. Biol. Chem. 272:32686-95 (1997).
RN [6]; RE0047808.
RX PUBMED: 12738762.
RA Taler M., Shpungin S., Salem Y., Malovani H., Pasder O., Nir U.
RT Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells.
RL Mol. Endocrinol. 17:1580-1592 (2003).
RN [7]; RE0047988.
RX PUBMED: 15385932.
RA Cho-Vega J. H., Rassidakis G. Z., Amin H. M., Tsioli P., Spurgers K., Remache Y. K., Vega F., Goy A. H., Gilles F., Medeiros L. J.
RT Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.
RL Leukemia 18:1872-1878 (2004).
RN [8]; RE0050787.
RX PUBMED: 14498832.
RA Zhang T., Ma J., Cao X.
RT Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling.
RL Biochem. J. 376:457-464 (2003).
RN [9]; RE0053327.
RX PUBMED: 15923602.
RA Proietti C., Salatino M., Rosemblit C., Carnevale R., Pecci A., Kornblihtt A. R., Molinolo A. A., Frahm I., Charreau E. H., Schillaci R., Elizalde P. V.
RT Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
RL Mol. Cell. Biol. 25:4826-4840 (2005).
RN [10]; RE0063497.
RX PUBMED: 18192275.
RA Bai Y., Ahmad U., Wang Y., Li J. H., Choy J. C., Kim R. W., Kirkiles-Smith N., Maher S. E., Karras J. G., Bennett C. F., Bothwell A. L., Pober J. S., Tellides G.
RT Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
RL J. Biol. Chem. 283:6832-6842 (2008).
RN [11]; RE0063709.
RX PUBMED: 18641358.
RA Fielding C. A., McLoughlin R. M., McLeod L., Colmont C. S., Najdovska M., Grail D., Ernst M., Jones S. A., Topley N., Jenkins B. J.
RT IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.
RL J. Immunol. 181:2189-2195 (2008).
RN [12]; RE0063914.
RX PUBMED: 17932422.
RA Guo Y., Mantel C., Hromas R. A., Broxmeyer H. E.
RT Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin.
RL Stem Cells 26:30-34 (2008).
RN [13]; RE0064592.
RX PUBMED: 15328362.
RA Paling N. R., Wheadon H., Bone H. K., Welham M. J.
RT Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.
RL J. Biol. Chem. 279:48063-48070 (2004).
RN [14]; RE0064701.
RX PUBMED: 15277698.
RA Humphrey R. K., Beattie G. M., Lopez A. D., Bucay N., King C. C., Firpo M. T., Rose-John S., Hayek A.
RT Maintenance of pluripotency in human embryonic stem cells is STAT3 independent.
RL Stem Cells 22:522-530 (2004).
RN [15]; RE0064723.
RX PUBMED: 19088203.
RA Huber M., Brustle A., Reinhard K., Guralnik A., Walter G., Mahiny A., von Low E., Lohoff M.
RT IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.
RL Proc. Natl. Acad. Sci. USA 105:20846-20851 (2008).
RN [16]; RE0064863.
RX PUBMED: 18614536.
RA Ozawa Y., Nakao K., Kurihara T., Shimazaki T., Shimmura S., Ishida S., Yoshimura A., Tsubota K., Okano H.
RT Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.
RL J. Biol. Chem. 283:24561-24570 (2008).
RN [17]; RE0064901.
RX PUBMED: 16705160.
RA Ishida-Takahashi R., Rosario F., Gong Y., Kopp K., Stancheva Z., Chen X., Feener E. P., Myers MG J. r.
RT Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling.
RL Mol. Cell. Biol. 26:4063-4073 (2006).
RN [18]; RE0065384.
RX PUBMED: 15930175.
RA Hogan J. C., Stephens J. M.
RT Effects of leukemia inhibitory factor on 3T3-L1 adipocytes.
RL J. Endocrinol. 185:485-496 (2005).
RN [19]; RE0065425.
RX PUBMED: 19632985.
RA Dumoutier L., de Meester C., Tavernier J., Renauld J. C.
RT New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain.
RL J. Biol. Chem. 284:26377-26384 (2009).
RN [20]; RE0065726.
RX PUBMED: 16698929.
RA Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B. M., Tato C., Yoshimura A., Hennighausen L., O'Shea J. J.
RT Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
RL Proc. Natl. Acad. Sci. USA 103:8137-8142 (2006).
RN [21]; RE0065994.
RX PUBMED: 15166220.
RA Dumoutier L., Tounsi A., Michiels T., Sommereyns C., Kotenko S. V., Renauld J. C.
RT Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.
RL J. Biol. Chem. 279:32269-32274 (2004).
RN [22]; RE0066821.
RX PUBMED: 10623831.
RA Schmitz J., Dahmen H., Grimm C., Gendo C., Muller-Newen G., Heinrich P. C., Schaper F.
RT The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
RL J. Immunol. 164:848-854 (2000).
RN [23]; RE0067228.
RX PUBMED: 12643274.
RA Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., Kallen K. J.
RT Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
RL J. Biol. Chem. 278:9528-9535 (2003).
RN [24]; RE0067430.
RX PUBMED: 20353755.
RA White U. A., Stephens J. M.
RT Neuropoietin activates STAT3 independent of LIFR activation in adipocytes.
RL Biochem. Biophys. Res. Commun. 395:48-50 (2010).
RN [25]; RE0067449.
RX PUBMED: 16096272.
RA Zvonic S., Baugh JE J. r., Arbour-Reily P., Mynatt R. L., Stephens J. M.
RT Cross-talk among gp130 cytokines in adipocytes.
RL J. Biol. Chem. 280:33856-33863 (2005).
RN [26]; RE0067469.
RX PUBMED: 18562323.
RA White U. A., Stewart W. C., Mynatt R. L., Stephens J. M.
RT Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes.
RL J. Biol. Chem. 283:22505-22512 (2008).
RN [27]; RE0067764.
RX PUBMED: 16547273.
RA Fritz D. K., Kerr C., Tong L., Smyth D., Richards C. D.
RT Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6.
RL J. Immunol. 176:4352-4360 (2006).
RN [28]; RE0067792.
RX PUBMED: 16459330.
RA Stross C., Radtke S., Clahsen T., Gerlach C., Volkmer-Engert R., Schaper F., Heinrich P. C., Hermanns H. M.
RT Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.
RL J. Biol. Chem. 281:8458-8468 (2006).
RN [29]; RE0068007.
RX PUBMED: 19651781.
RA Wang X., Zhao Q., Matta R., Meng X., Liu X., Liu C. G., Nelin L. D., Liu Y.
RT Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.
RL J. Biol. Chem. 284:27123-27134 (2009).
RN [30]; RE0068169.
RX PUBMED: 19112126.
RA Juan T. S., Bolon B., Lindberg R. A., Sun Y., Van G., Fletcher F. A.
RT Mice overexpressing murine oncostatin M (OSM) exhibit changes in hematopoietic and other organs that are distinct from those of mice overexpressing human OSM or bovine OSM.
RL Vet. Pathol. 46:124-137 (2009).
RN [31]; RE0068254.
RX PUBMED: 14611646.
RA Fischer P., Lehmann U., Sobota R. M., Schmitz J., Niemand C., Linnemann S., Haan S., Behrmann I., Yoshimura A., Johnston J. A., Muller-Newen G., Heinrich P. C., Schaper F.
RT The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
RL Biochem. J. 378:449-460 (2004).
RN [32]; RE0068341.
RX PUBMED: 20584990.
RA Larsen J. V., Hansen M., Moller B., Madsen P., Scheller J., Nielsen M., Petersen C. M.
RT Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.
RL Mol. Cell. Biol. 30:4175-4187 (2010).
RN [33]; RE0068797.
RX PUBMED: 16616006.
RA He F., Stephens J. M.
RT Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes.
RL Biochem. Biophys. Res. Commun. 344:95-98 (2006).
RN [34]; RE0069025.
RX PUBMED: 19254694.
RA Muromoto R., Taira N., Ikeda O., Shiga K., Kamitani S., Togi S., Kawakami S., Sekine Y., Nanbo A., Oritani K., Matsuda T.
RT The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.
RL Biochem. Biophys. Res. Commun. 382:63-68 (2009).
RN [35]; RE0069070.
RX PUBMED: 16140268.
RA Sato N., Tsuruma R., Imoto S., Sekine Y., Muromoto R., Sugiyama K., Matsuda T.
RT Nuclear retention of STAT3 through the coiled-coil domain regulates its activity.
RL Biochem. Biophys. Res. Commun. 336:617-624 (2005).
RN [36]; RE0069089.
RX PUBMED: 15607729.
RA Scheller J., Schuster B., Holscher C., Yoshimoto T., Rose-John S.
RT No inhibition of IL-27 signaling by soluble gp130.
RL Biochem. Biophys. Res. Commun. 326:724-728 (2005).
RN [37]; RE0069145.
RX PUBMED: 16636663.
RA Sekine Y., Tsuji S., Ikeda O., Sato N., Aoki N., Aoyama K., Sugiyama K., Matsuda T.
RT Regulation of STAT3-mediated signaling by LMW-DSP2.
RL Oncogene 25:5801-5806 (2006).
RN [38]; RE0069149.
RX PUBMED: 11846786.
RA Mellott T., Lopez-Coviella I., Blusztajn J. K., Berse B.
RT Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.
RL Eur. J. Biochem. 269:850-858 (2002).
RN [39]; RE0069424.
RX PUBMED: 19712053.
RA Lin H. W., Levison S. W.
RT Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia.
RL J. Neurochem 111:808-818 (2009).
RN [40]; RE0070066.
RX PUBMED: 20696842.
RA Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M. A., Yanez-Mo M., Sanchez-Madrid F.
RT CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.
RL Mol. Cell. Biol. 30:4877-4889 (2010).
RN [41]; RE0070088.
RX PUBMED: 19818650.
RA Gomez-Rodriguez J., Sahu N., Handon R., Davidson T. S., Anderson S. M., Kirby M. R., August A., Schwartzberg P. L.
RT Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
RL Immunity 31:587-597 (2009).
RN [42]; RE0070958.
RX PUBMED: 21829342.
RA Beyer T., Busse M., Hristov K., Gurbiel S., Smida M., Haus U. U., Ballerstein K., Pfeuffer F., Weismantel R., Schraven B., Lindquist J. A.
RT Integrating signals from the T-cell receptor and the interleukin-2 receptor.
RL PLoS Comput. Biol. 7:e1002121 (2011).
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