AC T00070
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ID T00070
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DT 15.10.1992 (created); ewi.
DT 10.04.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Pax-5
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SY B-cell specific activator protein; BSAP; BSAP/PAX-5, B-cell Specific Activating Protein; hPax-5; hPax5; Pax-5; PAX5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003921 PAX5; HGNC: PAX5.
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HO TSAP (sea urchin).
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CL C0017; paired; 3.2.2.2.2.
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SF 5 possible isoforms exists [11];
SF intact paired domain required for recognition of all Pax-5 binding sites [3];
SF a C-terminally truncated paired domain recognizes a subset of sites [3];
SF crystal structure of Pax-5/DNA and of ternary complex Pax-5/c-Ets-1/DNA has been solved [8];
SF beta-hairpin and helix B of N-terminal domain are involved in direct contact with c-Ets-1 [8];
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CP (pro-, pre-, mature B cells), astrocytic tumors [5]; tonsillar B cells (germinal centers and mantle zone) [12].
EX tonsil,B-lymphocyte,,adult; detectable; Northern blot; RNA (undefined); [12].
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FF activator [6];
FF regulator of B cell development [2];
FF tumor initiation by inhibiting the p53 transcription [5];
FF acts synergistically and directly interacts with c-Ets-1 [6] [7];
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IN T09205 Id3; human, Homo sapiens.
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MX M00143 V$PAX5_01.
MX M00144 V$PAX5_02.
MX M04064 V$PAX5_05.
MX M04754 V$PAX5_06.
MX M04765 V$PAX5_07.
MX M07223 V$PAX5_11.
MX M03577 V$PAX5_Q6.
MX M00808 V$PAX_Q6.
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BS R37605.
BS R57913.
BS R04285.
BS R04286.
BS R38866.
BS R35731.
BS R67123.
BS R67139.
BS R67140.
BS R67141.
BS R24137.
BS R24138.
BS R71687.
BS R37548.
BS R39327.
BS R29684.
BS R41906.
BS R38791.
BS R13323.
BS R28953.
BS R37616.
BS R37617.
BS R04583.
BS R04584.
BS R01666.
BS R01667.
BS R01662.
BS R01663.
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DR TRANSPATH: MO000024683.
DR TRANSCOMPEL: C00239.
DR UniProtKB: Q02548;
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RN [1]; RE0002744.
RX PUBMED: 2116362.
RA Barberis A., Widenhorn K., Vitelli L., Busslinger M.
RT A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
RL Genes Dev. 4:849-859 (1990).
RN [2]; RE0003103.
RX PUBMED: 1375324.
RA Kozmik Z., Wang S., Doerfler P., Adams B., Busslinger M.
RT The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP
RL Mol. Cell. Biol. 12:2662-2672 (1992).
RN [3]; RE0003116.
RX PUBMED: 8406007.
RA Czerny T., Schaffner G., Busslinger M.
RT DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site
RL Genes Dev. 7:2048-2061 (1993).
RN [4]; RE0004279.
RX PUBMED: 1516825.
RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
RT Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
RL Genes Dev. 6:1589-1607 (1992).
RN [5]; RE0011183.
RX PUBMED: 8521821.
RA Stuart E. T., Haffner R., Oren M., Gruss P.
RT Loss of p53 function through PAX-mediated transcriptional repression
RL EMBO J. 14:5638-5645 (1995).
RN [6]; RE0016685.
RX PUBMED: 8804314.
RA Fitzsimmons D., Hodsdon W., Wheat W., Maira S. M., Wasylyk B., Hagman J.
RT Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.
RL Genes Dev. 10:2198-2211 (1996).
RN [7]; RE0016687.
RX PUBMED: 10022910.
RA Wheat W., Fitzsimmons D., Lennox H., Krautkramer S. R., Gentile L. N., McIntosh L. P., Hagman J.
RT The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes.
RL Mol. Cell. Biol. 19:2231-2241 (1999).
RN [8]; RE0023824.
RX PUBMED: 11779502.
RA Garvie C. W., Hagman J., Wolberger C.
RT Structural studies of Ets-1/Pax5 complex formation on DNA.
RL Mol. Cell 8:1267-1276 (2001).
RN [9]; RE0042428.
RX PUBMED: 11799127.
RA Emelyanov A. V., Kovac C. R., Sepulveda M. A., Birshtein B. K.
RT The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells
RL J. Biol. Chem. 277:11156-64 (2002).
RN [10]; RE0047963.
RX PUBMED: 11134340.
RA Roberts E. C., Deed R. W., Inoue T., Norton J. D., Sharrocks A. D.
RT Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.
RL Mol. Cell. Biol. 21:524-533 (2001).
RN [11]; RE0056170.
RX PUBMED: 15385562.
RA Robichaud G. A., Nardini M., Laflamme M., Cuperlovic-Culf M., Ouellette R. J.
RT Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells.
RL J. Biol. Chem. 279:49956-49963 (2004).
RN [12]; RE0035360.
RX PUBMED: 12052884.
RA Lin K. I., Angelin-Duclos C., Kuo T. C., Calame K.
RT Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells.
RL Mol. Cell. Biol. 22:4771-4780 (2002).
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