AC T00152
AS T00155, T02527.
XX
ID T00152
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DT 26.01.1993 (created); ewi.
DT 09.08.2012 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA CP2
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SY alpha-CP2; alpha-CP2a; alpha-CP2a, alpha-CP2b; CP-2; CP2c; LBP-1c; LSF; SAA enhancer factor 1; SEF-1; Serum amyloid A3 Enhancer Factor 1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005244 Tfcp2.
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HO Elf-1 (Drosophila).
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CL C0051; Grainyhead; 6.7.2.0.1.
XX
SF belongs to the Granyhead-like family of TFs, together with Drosophila Elf-1/NTF-1 factors, and likely presents novel type of DNA binding;
SF recognizes DNA elements consisting of two directly repeated half-sites [5];
SF glutamine-rich region, phosphorylation;
XX
CP ts Epo, Ys Epo, FL E 12.5 [11].
EX adrenal gland (right + left),,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,adult; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX adrenal gland (right + left),,,adult; detectable; RT-PCR; total RNA; [7].
EX adrenal gland (right + left),,,adult; detectable; Western blot; protein; [7].
EX brain,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX brain,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX brain,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX brain,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX brain,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX brain,,,adult; detectable; RT-PCR; total RNA; [7].
EX brain,,,adult; detectable; Western blot; protein; [7].
EX future brain,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX gonadal ridge,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX gonadal ridge,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX gonadal ridge,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX gonadal ridge,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX heart,,,adult; detectable; RT-PCR; total RNA; [7].
EX heart,,,adult; detectable; Western blot; protein; [7].
EX hepatic primordium,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX hepatic primordium,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX kidney (right and left),,,adult; detectable; RT-PCR; total RNA; [7].
EX kidney (right and left),,,adult; detectable; Western blot; protein; [7].
EX liver bud,,,Theiler Stage 13; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver bud,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX liver,,,adult; detectable; RT-PCR; total RNA; [7].
EX liver,,,adult; detectable; Western blot; protein; [7].
EX lung bud,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung bud,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung bud,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung bud,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung bud,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung bud,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX lung,,,adult; detectable; RT-PCR; total RNA; [7].
EX lung,,,adult; detectable; Western blot; protein; [7].
EX metanephros,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX metanephros,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX metanephros,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX metanephros,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX metanephros,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX metanephros,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX muscles,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX muscles,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX muscles,,,adult; detectable; RT-PCR; total RNA; [7].
EX muscles,,,adult; detectable; Western blot; protein; [7].
EX nephric vesicles,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX ovary,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX ovary,,,adult; detectable; RT-PCR; total RNA; [7].
EX ovary,,,adult; detectable; Western blot; protein; [7].
EX precursor of muscles,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX precursor of muscles,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX precursor of muscles,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX precursor of muscles,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX precursor of muscles,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX spleen,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX spleen,,,adult; detectable; RT-PCR; total RNA; [7].
EX spleen,,,adult; detectable; Western blot; protein; [7].
EX testis (right and left),,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX testis (right and left),,,adult; detectable; RT-PCR; total RNA; [7].
EX testis (right and left),,,adult; detectable; Western blot; protein; [7].
EX thymus primordium,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX thymus primordium,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX thymus,,,adult; detectable; RT-PCR; total RNA; [7].
EX thymus,,,adult; detectable; Western blot; protein; [7].
EX urogenital ridge,,,Theiler Stage 14; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX urogenital ridge,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
EX urogenital ridge,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [7].
XX
FF activator [8];
FF appears to be functionally limiting in nuclear B cell extracts;
FF activates transcription of alpha-globin gene [4] [2] [1] [3];
FF activates transcription of the major acute phase gene SAA3 [8];
XX
IN T19309 LBP9; mouse, Mus musculus.
IN T19355 NF2d9-CP2b; mouse, Mus musculus.
IN T08970 NF2d9; mouse, Mus musculus.
XX
MX M00072 V$CP2_01.
MX M00947 V$CP2_02.
MX M07602 V$CP2_Q4.
MX M03868 V$CP2_Q6.
XX
BS R02866.
BS R06116.
BS R06117.
BS R06118.
BS R06119.
BS R06120.
BS R06121.
BS R04693.
BS R14309.
BS R26386.
BS R00090.
BS R23023.
BS R08104.
BS R01799.
XX
DR TRANSPATH: MO000024739.
DR TRANSCOMPEL: C00104.
DR UniProtKB: Q9ERA0;
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RN [1]; RE0001257.
RX PUBMED: 2905426.
RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M.
RT Identification and Characterization of Multiple Erythroid Cell Proteins That Interact with the Promoter of the Murine alpha-Globin Gene
RL Mol. Cell. Biol. 8:3215-3226 (1988).
RN [2]; RE0001258.
RX PUBMED: 3185549.
RA Kim C. G., Barnhart K. M., Sheffery M.
RT Purification of Multiple Erythroid Cell Proteins That Bind the Promoter of the alpha-Globin Gene
RL Mol. Cell. Biol. 8:4270-4281 (1988).
RN [3]; RE0001633.
RX PUBMED: 1732747.
RA Lim L. C., Swendeman S. L., Sheffery M.
RT Molecular cloning of the alpha-globin transcription factor CP2
RL Mol. Cell. Biol. 12:828-835 (1992).
RN [4]; RE0002945.
RX PUBMED: 2233727.
RA Kim C. G., Swendeman S. L., Barnhart K. M., Sheffery M.
RT Promoter elements and erythroid cell nuclear factors that regulate alpha-globin gene transcription in vitro
RL Mol. Cell. Biol. 10:5958-5966 (1990).
RN [5]; RE0003047.
RX PUBMED: 8349681.
RA Lim L. C., Fang L., Swendeman S. L., Sheffery M.
RT Characterization of the molecularly cloned murine alpha-globin transcription factor CP2
RL J. Biol. Chem. 268:18008-18017 (1993).
RN [6]; RE0007054.
RX PUBMED: 8007954.
RA Huang J. H., Liao W. S.-L.
RT Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor
RL Mol. Cell. Biol. 14:4475-4484 (1994).
RN [7]; RE0008932.
RX PUBMED: 8157699.
RA Swendeman S. L., Spielholz C., Jenkins N. A., Gilbert D. J., Copeland N. G., Sheffery M.
RT Characterization of the genomic structure, chromosomal location, promoter and developmental expression of the alpha-globin transcription factor CP2
RL J. Biol. Chem. 269:11663-11671 (1994).
RN [8]; RE0022225.
RX PUBMED: 10455131.
RA Bing Z., Reddy S. A., Ren Y., Qin J., Liao W. S.
RT Purification and characterization of the serum amyloid A3 enhancer factor.
RL J. Biol. Chem. 274:24649-24656 (1999).
RN [9]; RE0023445.
RX PUBMED: 12888489.
RA Venkatesan K., McManus H. R., Mello C. C., Smith T. F., Hansen U.
RT Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
RL Nucleic Acids Res. 31:4304-4316 (2003).
RN [10]; RE0047803.
RX PUBMED: 15988015.
RA Kang H. C., Chae J. H., Lee Y. H., Park M. A., Shin J. H., Kim S. H., Ye S. K., Cho Y. S., Fiering S., Kim C. G.
RT Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family.
RL Mol. Cell. Biol. 25:6005-6020 (2005).
RN [11]; RE0051805.
RX PUBMED: 16648487.
RA Bose F., Fugazza C., Casalgrandi M., Capelli A., Cunningham J. M., Zhao Q., Jane S. M., Ottolenghi S., Ronchi A.
RT Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters.
RL Mol. Cell. Biol. 26:3942-3954 (2006).
XX
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