AC T00208
XX
ID T00208
XX
DT 27.10.1992 (created); ewi.
DT 29.11.2005 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA E74A
XX
SY E74A.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G000097 Eip74EF.
XX
CL C0016; ETS.
XX
SZ 829 AA; 87.1 kDa (cDNA) (calc.).
XX
SQ MPFIDDALLWCPDNDGRLVGGLDLGTCIADDSTANGTENLNPSIQSAGNPNNPQQSVGGE
SQ ILGSVESAGNELNGAAARNVNVVVEPLCGGDSSDELFRSFSESNFEIESLLSDLATVEVK
SQ VENEENNNNVITDDDFASVAAAVVANDDLLAKENAQLSAQGLVDSVAASLADSGDAGGQQ
SQ ALLAFGSSSSAASAIAAAAAALCGDLINNNNNNSNSNNNSNGNGNHGGGGGGASSGGGVA
SQ GDCATKLEYALMGGQPLAEEPRFVTSAAANPLLVEKLMSKCLNIEKRMDKLSDTEIPIVK
SQ QSTSPAPQQQLQQQHHLQQQQQQQPHNGSTFAGATALLHIKTEQNTLLTPLQLQQQQQQQ
SQ QGLHGAAGNGGSSNGNNAHQQQQPLAIPQRPLLHNLLSGGAIHNPHHRNYTTATTGSFPP
SQ SPADSGVSDVDSSSSGGQPCADELKARLGMPPATSASAAAAAAAAAAAAAHLHTGTFLHP
SQ NLYQNNAANSLRNIWNRSVGVPDNYYGSSGAGSGGTQPGGPGNPQTPGYLTTSYFNAPTA
SQ ATAAASQRGTTINGYHSLHQQQQQQQQSQQSQQQQQLAHQQLSHQQQQALHQQLSHQQQQ
SQ QQQQQQQHPHSQLNGPHPHSHPHSHPHSHPHAGQHTHSTIAAAAAAAAASVVSSSSSAVA
SQ AAAMLSASAAAAATAAAAAGGSQSVIQPATSSVSYDLSYMLELGGFQQRKAKKPRKPKLE
SQ MGVKRRSREGSTTYLWEFLLKLLQDREYCPRFIKWTNREKGVFKLVDSKAVSRLWGMHKN
SQ KPDMNYETMGRALRYYYQRGILAKVDGQRLVYHFVDVPKDIIEIDCNGV
XX
SC Swiss-Prot#P20105
XX
FT 411 763 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 570 579 
PF00904; Involucrin repeat.
FT 582 591 
PF00904; Involucrin repeat.
FT 732 817 
PF00178; Ets-domain.
FT 732 819 
SM00413; etsneu2.
FT 733 815 
PS50061; ETS_DOMAIN_3.
FT 735 805 
PS50140; HSF_ETS.
XX
CP late third instar larvae: widespread, highest level in brain and other nervous tissue, proventriculus of gut, salivary.
XX
FF ecdysone-induced, subsequently repressed by other ecdysone-induced proteins [3];
FF expression peaks at 18-24 h during embryonal development and re-appears at 36-58, at 60-72 h, at 108-120 h (third instar larvae), at 144-180 (pupae), and in adult flies [3];
FF some peaks are due to ecdysone induction, others to distinct inducers [3];
XX
MX M00016 I$E74A_01.
XX
BS R05287.
BS R05288.
BS R05289.
BS R05290.
BS R05291.
BS R05292.
BS R05293.
BS R05294.
BS R05295.
BS R05296.
BS R05297.
BS R05298.
BS R05299.
BS R05300.
BS R05301.
BS R05302.
BS R12320.
BS R02386.
BS R02387.
BS R02388.
BS R02389.
BS R04535.
XX
DR TRANSPATH: MO000045948.
DR EMBL: M37082; DME74A.
DR UniProtKB: P20105; E74A_DROME.
DR FLYBASE: FBgn0000567.
XX
RN [1]; RE0000194.
RX PUBMED: 2107982.
RA Burtis K. C., Thummel C. S., Jones C. W., Karim F. D., Hogness D. S.
RT The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins
RL Cell 61:85-99 (1990).
RN [2]; RE0005364.
RX PUBMED: 1569949.
RA Martin M. E., Yang X. Y., Folk W. R.
RT Expression of a 91-Kilodalton PEA3-binding protein is down-regulated during differentiation of F9 embryonal carcinoma cells
RL Mol. Cell. Biol. 12:2213-2221 (1992).
RN [3]; RE0005365.
RX PUBMED: 1690603.
RA Thummel C. S., Burtis K. C., Hogness D. S.
RT Spatial and temporal patterns of E74 transcription during Drosophila development
RL Cell 61:101-111 (1990).
XX
//