AC T00376
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ID T00376
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DT 14.05.1993 (created); ewi.
DT 15.04.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA HOXD4
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SY HHO.C13; HOX-5.1; HOX4B.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009135 HOXD4; HGNC: HOXD4.
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HO Dfd (Drosophila).
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CL C0006; homeo; 3.1.1.4.4.
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SF low affinity to homeo domain binding sites in upstream homeobox genes (KD = 14.3-30.0 nM), high affinity binding to an element in the own promoter [3];
SF same DNA-binding specificity as insect Dfd and the paralogous HOXA4 [6];
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CP embryonic brain, spinal chord, backbone, heart, limb buds [1]; (embryo 11 weeks:) fetal brain [7] [7] [1].
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FF inducible by retinoic acid [1];
FF two alternative promoters give rise to mRNAs of different expression patterns and different mRNA-stabilities [1];
FF positive autoregulation, but no activation of upstream genes [2] [4];
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MX M08774 V$HOXD4_01.
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DR TRANSPATH: MO000043396.
DR UniProtKB: P09016; HXD4_HUMAN.
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RN [1]; RE0002086.
RX PUBMED: 1975093.
RA Cianetti L., Di Cristofaro A., Zappavigna V., Bottero L., Boccoli G., Testa U., Russo G., Boncinelli E., Peschle C.
RT Molecular mechanisms underlying the expression of the human HOX-5.1 gene
RL Nucleic Acids Res. 18:4361-4368 (1990).
RN [2]; RE0003914.
RX PUBMED: 1346761.
RA Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E., Mavilio F.
RT The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins
RL EMBO J. 11:265-277 (1992).
RN [3]; RE0003970.
RX PUBMED: 1357628.
RA Corsetti M. T., Briata P., Sanseverino L., Daga A., Airoldi I., Simeone A., Palmisano G., Angelini C., Boncinelli E., Corte G.
RT Differential DNA binding properties of three human homeodomain proteins
RL Nucleic Acids Res. 20:4465-4472 (1992).
RN [4]; RE0004056.
RX PUBMED: 1353609.
RA Malicki J., Cianetti L. C., Peschle C., McGinnis W.
RT A human HOX4B regulatory element provides head specific expression in Drosophila embryos
RL Nature 358:345-347 (1992).
RN [5]; RE0004058.
RX PUBMED: 2879245.
RA Acampora D., Poiana G., Russo G., Peschle C., Boncinelli E.
RT Differential and stage related expression in embryonic tissues of a new human homeobox gene
RL Nature 324:664-668 (1986).
RN [6]; RE0004063.
RX PUBMED: 1347746.
RA Dessain S., Gross C. T., Kuziora M. A., McGinnis W.
RT Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos
RL EMBO J. 11:991-1002 (1992).
RN [7]; RE0015345.
RX PUBMED: 8838315.
RA Lin X., Swaroop A., Vaccarino F. M., Murtha M. T., Haas M., Ji X., Ruddle F. H., Leckman J. F.
RT Characterization and sequence analysis of the human homeobox-containing gene GBX2
RL Genomics 31:335-342 (1996).
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