AC T00515
XX
ID T00515
XX
DT 26.01.1993 (created); hse.
DT 22.02.2011 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA MTF-1
XX
SY MEP-1; metal element protein-1; metal-regulatory transcription factor 1; MTF-1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009179 Mtf1.
XX
CL C0001; CH; 2.3.3.24.1.
XX
SF large sequence identity to human MTF-1 [4];
SF acidic region as well as P-rich and S/T-rich region function as activating domains [8];
XX
CP testis, liver, kidney, spleen [7].
XX
FF binds to metal response elements (MRE), related to Sp1 [2];
FF required for basal transcription of metallothionein I and II genes [6];
FF required for induction of metallothionein by zinc as well as cadmium, copper, nickel and lead [6] [7];
FF involved in regulation of expression of the heavy-chain subunit of the gamma-glutamylcysteine synthetase [10];
FF properties may be modulated by intracellular zinc concentration [6];
FF most deletions reduce or abolish activity [8];
FF cells lacking MTF-1 show increased susceptibility to the cytotoxic effects of cadmium or hydrogen peroxide and mouse embryos lacking MTF-1 die in utero at app. day 14 of gestation [10];
FF not only heavy metals, but also oxidative stress (H2O2) or hypoxia lead to increased MTF-1 activity and metallothionein expression [11] [12];
XX
MX M01242 V$MTF1_01.
MX M01243 V$MTF1_02.
MX M02778 V$MTF1_05.
MX M00650 V$MTF1_Q4.
MX M04619 V$MTF1_Q5.
XX
BS R08298.
BS R21643.
BS R02016.
BS R03449.
BS R03450.
BS R08297.
BS R02204.
BS R01816.
XX
DR TRANSPATH: MO000046027.
DR UniProtKB: Q07243; MTF1_MOUSE.
XX
RN [1]; RE0000683.
RX PUBMED: 3371659.
RA Mueller P. R., Salser S. J., Wold B.
RT Constitutive and metal-inducible protein: DNA interactions at the mouse metallothionein I promoter examined by in in vivo and in vitro footprinting
RL Genes Dev. 2:412-427 (1988).
RN [2]; RE0001482.
RX PUBMED: 2725504.
RA Culotta V. C., Hamer D. H.
RT Fine mapping of a mouse metallothionein gene metal response element
RL Mol. Cell. Biol. 9:1376-1380 (1989).
RN [3]; RE0002180.
RX PUBMED: 1870976.
RA Labbe S., Prevost J., Remondelli P., Leone A., Seguin C.
RT A nuclear factor binds to the metal regulatory elements of the mouse gene encoding metallothionein-I
RL Nucleic Acids Res. 19:4225-4231 (1991).
RN [4]; RE0006649.
RX PUBMED: 8065932.
RA Brugnera E., Georgiev O., Radtke F., Heuchel R., Baker E., Sutherland G. R., Schaffner W.
RT Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1
RL Nucleic Acids Res. 22:3167- 3173 (1994).
RN [5]; RE0006650.
RX PUBMED: 8467794.
RA Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W.
RT Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter
RL EMBO J. 12:1355-1362 (1993).
RN [6]; RE0006706.
RX PUBMED: 8026472.
RA Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., Schaffner W.
RT The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
RL EMBO J. 13:2870-2875 (1994).
RN [7]; RE0006723.
RX PUBMED: 8108390.
RA Palmiter R. D.
RT Regulation of metallothionein genes by heavy metals appers to be mediated by a zinc-sensitive inhibitor that interacts with a contstitutively active transcription factor, MTF-1
RL Proc. Natl. Acad. Sci. USA 91:1219- 1223 (1994).
RN [8]; RE0006724.
RX PUBMED: 7610056.
RA Radtke F., Georgiev O., Muller H.-P., Brugnera E., Schaffner W.
RT Functional domains of the heavy metal-responsive transcription regulator MTF-1
RL Nucleic Acids Res. 23:2277-2286 (1995).
RN [9]; RE0007200.
RX PUBMED: 8479904.
RA Labbe S., Larouche L., Mailhot D., Seguin C.
RT Purification of mouse MEP-1, a nuclear protein which binds to the metal regulatory elements of genes encoding metallothionein
RL Nucleic Acids Res. 21:1549-1554 (1993).
RN [10]; RE0013733.
RX PUBMED: 9582278.
RA Guenes C., Heuchel R., Georgiev O., Muller K.-H., Lichtlen P., Bluthmann H., Marino S., Aguzzi A., Schaffner W.
RT Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.
RL EMBO J. 17:2846-2854 (1998).
RN [11]; RE0013734.
RX PUBMED: 8824273.
RA Dalton T. P., Li Q., Bittel D., Liang L., Andrews G. K.
RT Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter.
RL J. Biol. Chem. 271:26233-26241 (1996).
RN [12]; RE0013735.
RX PUBMED: 10096565.
RA Murphy B. J., Andrews G. K., Bittel D., Discher D. J., McCue J., Green C. J., Yanovsky M., Giaccia A., Sutherland R. M., Laderoute K. R., Webster K. A.
RT Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.
RL Cancer Res. 59:1315-1322 (1999).
XX
//