AC T00684
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ID T00684
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DT 15.10.1992 (created); ewi.
DT 16.05.2014 (updated); vad.
CO Copyright (C), QIAGEN.
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FA PEA3
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SY E1A (adenovirus) enhancer-binding factor; E1A-F; ETV4; PEA-3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009201 Etv4.
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CL C0016; ETS; 3.5.2.2.5.
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SF (conflict: H-429 is missing in SwissProt #P28322);
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CP epidermis, brain; lower levels in lung, mammary gland, pancreas [3].
CN bone marrow, heart, kidney, liver, salivary gland, spleen, testis, thymus [3].
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FF Pea3 shows no significant increase in the transcriptional activity by addition of PKA (protein kinase A) [9];
FF activator [3];
FF functional cooperation with PEA1/AP-1 in activation and for polyoma virus replication [5] [7];
FF serum-activated, target for several non-nuclear oncogenes (Src, Py-middle T, Ha-Ras, mos, raf, not: fos) [1];
FF down-regulated during RA-induced differentiation of embryonic cell lines [3];
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MX M00971 V$ETS_Q6.
MX M01991 V$PEA3_01.
MX M00655 V$PEA3_Q6.
MX M03579 V$PEA3_Q6_02.
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BS R19160.
BS R26694.
BS R20319.
BS R29714.
BS R17224.
BS R33318.
BS R18125.
BS R26484.
BS R21054.
BS R02095.
BS R59129.
BS R61824.
BS R29703.
BS R15134.
BS R26711.
BS R01224.
BS R02232.
BS R17225.
BS R18127.
BS R18128.
BS R18130.
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DR TRANSPATH: MO000046034.
DR TRANSCOMPEL: C00086.
DR TRANSCOMPEL: C00268.
DR TRANSCOMPEL: C00269.
DR UniProtKB: P28322; ETV4_MOUSE.
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RN [1]; RE0000395.
RX PUBMED: 2555163.
RA Wasylyk C., Flores P., Gutman A., Wasylyk B.
RT PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes
RL EMBO J. 8:3371-3378 (1989).
RN [2]; RE0000614.
RX PUBMED: 2163347.
RA Gunther C. V., Nye J. A., Bryner R. S., Graves B. J.
RT Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus
RL Genes Dev. 4:667-679 (1990).
RN [3]; RE0000804.
RX PUBMED: 1547944.
RA Xin J.-H., Cowie A., Lachance P., Hassell J. A.
RT Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells
RL Genes Dev. 6:481-496 (1992).
RN [4]; RE0001866.
RX PUBMED: 2114554.
RA Wasylyk B., Wasylyk C., Flores P., Begue A., Leprince D., Stehelin D.
RT The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation
RL Nature 346:191-193 (1990).
RN [5]; RE0002339.
RX PUBMED: 2842750.
RA Martin M. E., Piette J., Yaniv M., Tang W.-J., Folk W. R.
RT Activator of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins
RL Proc. Natl. Acad. Sci. USA 85:5839-5843 (1988).
RN [6]; RE0002743.
RX PUBMED: 2162765.
RA Gutman A., Wasylyk B.
RT The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites
RL EMBO J. 9:2241-2246 (1990).
RN [7]; RE0005329.
RX PUBMED: 2167444.
RA Rochford R., Davis C. T., Yoshimoto K., Villarreal L. P.
RT Minimal subenhancer requirements for high-level polyomavirus DNA replication: A cell-specific synergy of PEA3 and PEA1 sites
RL Mol. Cell. Biol. 10:4996-5001 (1990).
RN [8]; RE0016582.
RX PUBMED: 2119494.
RA Rorth P., C. Nerlov, F. Blasi, Johnsen M.
RT Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester.
RL Nucleic Acids Res. 18:5009-5017 (1990).
RN [9]; RE0035423.
RX PUBMED: 11682477.
RA Baert J. L., Beaudoin C., Coutte L., de Launoit Y.
RT ERM transactivation is up-regulated by the repression of DNA binding after the PKA phosphorylation of a consensus site at the edge of the ETS domain.
RL J. Biol. Chem. 277:1002-1012 (2002).
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