TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00691 XX ID T00691 XX DT 15.10.1992 (created); ewi. DT 27.08.2007 (updated); ask. CO Copyright (C), QIAGEN. XX FA Pit-1A XX SY GHF-2; LSF-1; Pit-1; Pit-1a; Pituitary-specific factor 1; POU1F1a; PUF-1; PUF-I. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G000740 Pou1f1. XX CL C0007; POU; XX SZ 317 AA; 35.8 kDa (cDNA) (calc.), 43 kDa (SDS) [2], 33.0 + 34.5 kDa (SDS) [2] XX SQ MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNVMSTVPSILSLIQTPKC SQ LHTYFSMTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLH SQ QPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVG SQ EALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERK SQ RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKT SQ SLNQSLFSISKEHLECR XX SC Swiss-Prot#P10037-2 XX FT 10 40 major trans-activation domain [15]. FT 150 224 PF00157; Pou domain - N-terminal to homeobox domain. FT 150 224 SM00352; pou. FT 238 298 PS50071; HOMEOBOX_2. FT 238 300 PS50550; POU_HOMEODOMAIN. FT 240 302 SM00389; HOX_1. FT 241 297 PF00046; Homeobox domain. XX SF alternative splicing gives rise to a 291 AA protein which is the major form; SF Pit-1A makes approximately 1/7 of all POU1F1 mRNA in pituitary cells [17] [20]; SF alternative translation initiation gives rise to another product of 31 kDa [23]; SF both POUs and POUh contact DNA [15]; SF POUh domain is sufficient for DNA-binding, POUs and the linker region between POUs and POUh augment in enhancing affinity and specificity [15] [19] [9]; SF POUs induces bending of the DNA [4]; SF free in solution: POU1F1 monomers or POU1F1/POU2F1 T00643 heterodimers, homodimers form upon DNA-binding [15] [29]; SF interacts physically with PITX2 T02413 to facilitate DNA binding [28]; XX CP lactotrophs, somatotrophs and thyrotrophs of anterior pituitary gland [18] [6] [2]. CN gonadotrophs of anterior pituitary gland, posterior pituitary, heart, hypothalamus, kidney, liver, prostate, testis, thyroid [18] [6] [2]. XX FF tissue-specific activator [9] [2]; FF although binding to POU1F1 sites like POU1F1b, it trans-activates the growth hormone (GH) gene, but not the Prl and GHF1 promoters (in contrast to GHF-1) due to the 26 AA insertion [17]; FF transcription of the pit-1 gene is triggered by environmental stimuli that enhance intracellular cAMP concentrations [22]; FF autoregulation through several promoter and enhancer elements [21] [22] [25]; FF may also be regulated through a potent vitamin D3 responsive element [25]; FF may be subject of differential cell-type specific translational control [18]; FF activity at the GH promoter is counteracted by activin [16]; FF acts with PITX2 T02413 to synergistically transactivate the prolactin gene promoter [28]; XX IN T02413 pitx2; human, Homo sapiens. XX MX M01465 V$PIT1_01. MX M00802 V$PIT1_Q6. MX M03559 V$PIT1_Q6_01. MX M00744 V$POU1F1_Q6. XX BS R02160. BS R03190. BS R03191. BS R03955. BS R16148. BS R00609. BS R00611. BS R00612. BS R19140. BS R19141. BS R02783. BS R02784. BS R02786. BS R02787. BS R02789. BS R02790. BS R02791. BS R02792. BS R03481. BS R03483. BS R16142. BS R16144. BS R16145. BS R16149. BS R13387. BS R13388. BS R16143. BS R16146. BS R16147. BS R16150. BS R20583. BS R74086. BS R00622. BS R00623. BS R13389. BS R01263. BS R01264. BS R01265. BS R01266. BS R01270. BS R01273. BS R01276. BS R01279. BS R01280. BS R74087. XX DR TRANSPATH: MO000025109. DR TRANSCOMPEL: C00047. DR TRANSCOMPEL: C00131. DR TRANSCOMPEL: C00137. DR TRANSCOMPEL: C00360. DR TRANSCOMPEL: C00361. DR TRANSCOMPEL: C00362. DR TRANSCOMPEL: C00363. DR TRANSCOMPEL: C00364. DR TRANSCOMPEL: C00366. DR TRANSCOMPEL: C00367. DR EMBL: X63089; DR EMBL: X65364; DR EMBL: X65365; DR EMBL: X65367; DR EMBL: X65368; DR UniProtKB: P10037-2; XX RN [1]; RE0000072. RX PUBMED: 3594572. RA Bodner M., Karin M. RT A Pituitary-Specific Trans-Acting Factor Can Stimulate Transcription from the Growth Hormone Promoter in Extracts of Nonexpressing Cells RL Cell 50:267-275 (1987). RN [2]; RE0000076. RX PUBMED: 2902928. RA Ingraham H. A., Chen R., Mangalam H. J., Elsholtz H. P., Flynn S. E., Lin C. R., Simmons D. M., Swanson L., Rosenfeld M. G. RT A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype RL Cell 55:519-529 (1988). RN [3]; RE0000347. RX PUBMED: 3595566. RA Lefevre C., Imagawa M., Dana S., Grindlay J., Bodner M., Karin M. RT Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor RL EMBO J. 6:971-981 (1987). RN [4]; RE0000528. RX PUBMED: 1915275. RA Verrijzer C. P., van Oosterhout J. A. W. M., van Weperen W. W., van der Vliet P. C. RT POU proteins bend DNA via the POU-specific domain RL EMBO J. 10:3007-3014 (1991). RN [5]; RE0000616. RX PUBMED: 2307370. RA Elsholtz H. P., Albert V. R., Treacy M. N., Rosenfeld M. G. RT A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression RL Genes Dev. 4:43-51 (1990). RN [6]; RE0000645. RX PUBMED: 2550324. RA Mangalam H. J., Albert V. R., Ingraham H. A., Kapiloff M., Wilson L., Nelson Ch., Elsholtz H., Rosenfeld M. G. RT A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally RL Genes Dev. 3:946-958 (1989). RN [7]; RE0001331. RX PUBMED: 3683387. RA Cao Z., Barron E. A., Carillo A. J., Sharp Z. D. RT Reconstitution of Cell-Type-Specific Transcription of the Rat Prolactin Gene In Vitro RL Mol. Cell. Biol. 7:3402-3408 (1987). RN [8]; RE0001332. RX PUBMED: 3244361. RA Cao Z., Barron E. A., Sharp Z. D. RT Prolactin Upstream Factor I Mediates Cell-Specific Transcription RL Mol. Cell. Biol. 8:5432-5438 (1988). RN [9]; RE0001790. RX PUBMED: 2574416. RA Theill L. E., Castrillo J.-L., Wu D., Karin M. RT Dissection of functional domains of the pituitary-specific transcription factor GHF-1 RL Nature 342:945-948 (1989). RN [10]; RE0002021. RX PUBMED: 2717408. RA Sharp Z. D., Helsel S., Cao Z., Barron E. A., Sanchez Y. RT DNA recognition element required for PUF-I mediated cell-type specific transcription of the rat prolactin gene RL Nucleic Acids Res. 17:2705-2722 (1989). RN [11]; RE0002079. RX PUBMED: 1976240. RA Schaufele F., West B. L., Reudelhuber T. RT Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter RL Nucleic Acids Res. 18:5235-5244 (1990). RN [12]; RE0002474. RX PUBMED: 1901656. RA Steinfelder H. J., Hauser P., Nakayama Y., Radovick S., McClaskey J. H., Taylor T., Weintraub B. D., Wondisford F. E. RT Thyrotropin-releasing hormone regulation of human TSHB expression: Role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element RL Proc. Natl. Acad. Sci. USA 88:3130-3134 (1991). RN [13]; RE0002599. RX PUBMED: 2831625. RA Nelson C., Albert V. R., Elsholtz H. P., Lu L. I.-W., Rosenfeld M. G. RT Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor RL Science 239:1400-1405 (1988). RN [14]; RE0002639. RX PUBMED: 2563596. RA Castrillo J.-L., Bodner M., Karin M. RT Purification of growth hormone-specific transcription factor GHF-1 containing homeobox RL Science 243:814-817 (1989). RN [15]; RE0002735. RX PUBMED: 2350782. RA Ingraham H. A., Flynn S. E., Voss J. W., Albert V. R., Kapiloff M. S., Wilson L., Rosenfeld M. G. RT The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions RL Cell 61:1021-1033 (1990). RN [16]; RE0002950. RX PUBMED: 1454833. RA Struthers R. S., Gaddy-Kurten D., Vale W. W. RT Activin inhibits binding of transcription factor Pit-1 to the growth hormone promoter RL Proc. Natl. Acad. Sci. USA 89:11451-11455 (1992). RN [17]; RE0003111. RX PUBMED: 1600947. RA Theill L. E., Hattori K., Lazzaro D., Castrillo J.-L., Karin M. RT Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins RL EMBO J. 11:2261-2269 (1992). RN [18]; RE0003182. RX PUBMED: 2379827. RA Simmons D.M., Voss J.W., Ingraham H.A., Holloway J.M., Broide R.S., Rosenfeld M.G., Swanson L.W. RT Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors RL Genes Dev. 4:695-711 (1990). RN [19]; RE0004205. RX PUBMED: 1732727. RA Aurora R., Herr W. RT Segments of the POU domain influence one another's DNA-binding specificity RL Mol. Cell. Biol. 12:455-467 (1992). RN [20]; RE0004420. RX PUBMED: 1561093. RA Morris A. E., Kloss B., McCesney R. E., Bancroft C., Chasin L. A. RT An alternatively spliced Pit-1 isoform altered in its ability to trans-activate RL Nucleic Acids Res. 20:1355-1361 (1992). RN [21]; RE0004424. RX PUBMED: 2142999. RA Chen R., Ingraham H. A., Treacy M. N., Albert V. R., Wilson L., Rosenfeld M. G. RT Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements RL Nature 346:583-586 (1990). RN [22]; RE0004427. RX PUBMED: 1972784. RA McCormick A., Brady H., Theill L. E., Karin M. RT Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues RL Nature 345:829-832 (1990). RN [23]; RE0004428. RX PUBMED: 2071572. RA Voss J. W., Yao T.-P., Rosenfeld M. G. RT Alternative translation initiation site usage results in two structurally distinct forms of Pit-1 RL J. Biol. Chem. 266:12832-12835 (1991). RN [24]; RE0004431. RX PUBMED: 1779976. RA Hoggard N., Davis J. R. E., Berwaer M., Monget P., Peers B., Belayew A., Martial J. A. RT Pit-1 binding sequences permit calcium regulation of human prolactin gene expression RL Mol. Endocrinol. 5:1748-1754 (1991). RN [25]; RE0004438. RX PUBMED: 8504933. RA Rhodes S. J., Chen R., DiMattia G. E., Scully K. M., Kalla K. A., Lin S.-C., Yu V. C., Rosenfeld M. G. RT A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene RL Genes Dev. 7:913-932 (1993). RN [26]; RE0004439. RX PUBMED: 8163504. RA Lew A. M., Yao H., Elsholtz H. P. RT Gia2- and G0a-mediated signaling in the Pit-1-dependent inhibition of the prolactin gene promoter RL J. Biol. Chem. 269:12007-12013 (1994). RN [27]; RE0004445. RX PUBMED: 1775132. RA Yan G. Z., Bancroft C. RT Mediation by calcium of thyrotropin--releasing hormone action on the prolactin promoter via transcription factor pit-1 RL Mol. Endocrinol. 5:1488-1497 (1991). RN [28]; RE0016332. RX PUBMED: 9685346. RA Amendt B. A., Sutherland L. B., Semina E. V., Russo A. F. RT The molecular basis of Rieger Syndrome RL J. Biol. Chem. 273:20066-20072 (1998). RN [29]; RE0016563. RX PUBMED: 2065979. RA Voss J. W., Wilson L., Rosenfeld M. G. RT POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter. RL Genes Dev. 5:1309-1320 (1991). RN [30]; RE0016603. RX PUBMED: 7673116. RA Howard P. W., Maurer R. A. RT A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways. RL J. Biol. Chem. 270:20930-20936 (1995). RN [31]; RE0022675. RX PUBMED: 1321428. RA Steinfelder H. J., Radovick S., Wondisford F. E. RT Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1. RL Proc. Natl. Acad. Sci. USA 89:5942-5945 (1992). RN [32]; RE0022755. RX PUBMED: 1652153. RA Kapiloff M. S., Farkash Y., Wegner M., Rosenfeld M. G. RT Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements. RL Science 253:786-789 (1991). XX //