AC T00697
XX
ID T00697
XX
DT 15.10.1992 (created); ewi.
DT 13.06.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA PR B
XX
SY NR3C3; NR3C3b; PR; progesterone receptor.
XX
OS rabbit, Oryctolagus cuniculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; lagomorpha; leporidae
XX
GE G000677 PGR.
XX
CL C0002; CC (rec).
XX
SZ 930 AA; 98.7 kDa (cDNA) (calc.), 110 kDa (SDS) [10]
XX
SQ MTELKAKEPRAPHVAGGAPSPTEVGSQLLGRPDPGPFQGSQTSEASSVVSAIPISLDGLL
SQ FPRPCQGQNPPDGKTQDPPSLSDVEGAFPGVEAPEGAGDSSSRPPEKDSGLLDSVLDTLL
SQ APSGPGQSHASPATCEAISPWCLFGPDLPEDPRAAPATKGVLAPLMSRPEDKAGDSSGTA
SQ AAHKVLPRGLSPSRQLLLPSSGSPHWPAVKPSPQPAAVQVDEEDSSESEGTVGPLLKGQP
SQ RALGGTAAGGGAAPVASGAAAGGVALVPKEDSRFSAPRVSLAEQDAPVAPGRSPLATSVV
SQ DFIHVPILPLNHAFLATRTRQLLEGESYDGGAAAASPFVPQRGSPSASSTPVAGGDFPDC
SQ TYPPDAEPKDDAFPLYGDFQPPALKIKEEEEAAEAAARSPRTYLVAGANPAAFPDFQLAA
SQ PPPPSLPPRVPSSRPGEAAVAASPGSASVSSSSSSGSTLECILYKAEGAPPQQGPFAPLP
SQ CKPPGAGACLLPRDGLPSTSASGAAAGAAPALYPTLGLNGLPQLGYQAAVLKEGLPQVYT
SQ PYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQH
SQ NYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDAVALPQP
SQ VGIPNESQRITFSPSQEIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGE
SQ RQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI
SQ LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQSQFEE
SQ MRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSV
SQ EFPEMMSEVIAAQLPKILAGMVKPLLFHKK
XX
SC translated from EMBL #M14547
XX
FT 1 565 
PF02161; Progesterone receptor.
FT 263 742 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 565 636 
SM00399; c4gold.
FT 565 640 
PS51030; NUCLEAR_REC_DBD_2.
FT 566 641 
PF00105; Zinc finger, C4 type (two domains).
FT 717 881 
SM00430; holi.
FT 720 905 
PF00104; Ligand-binding domain of nuclear hormon.
XX
SF 3 different nuclear localization signals within second zinc finger, at the C/D region border, and a weak hormone-inducible one within the HBD [10];
XX
CP (uterus).
XX
IN T00697 PR B; rabbit, Oryctolagus cuniculus.
XX
MX M00960 V$PR_Q2.
MX M03799 V$PR_Q6.
XX
BS R03525.
BS R03559.
BS R03560.
BS R00983.
BS R00985.
BS R01575.
BS R01102.
BS R01104.
BS R01106.
BS R01107.
BS R01108.
BS R01112.
BS R01117.
BS R01118.
BS R01120.
BS R01123.
BS R01124.
BS R02234.
BS R03270.
BS R03271.
BS R01546.
BS R01548.
BS R01551.
BS R01552.
BS R01553.
BS R01554.
BS R01555.
BS R01556.
XX
DR TRANSPATH: MO000021452.
DR EMBL: M14547; OCPGR.
DR UniProtKB: P06186-1;
XX
RN [1]; RE0000410.
RX PUBMED: 3816760.
RA Bailly A., Le Page C., Rauch M., Milgrom E.
RT Sequence-specific DNA binding of the progesterone receptor to the uteroglobin gene: effects of hormone, antihormone and receptor phosphorylation
RL EMBO J. 5:3235-3241 (1986).
RN [2]; RE0000518.
RX PUBMED: 2050123.
RA Savouret J. F., Bailly A., Mirashi M., Rauch C., Redeuilh G., Chauchereau A., Milgrom E.
RT Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene
RL EMBO J. 10:1875-1883 (1991).
RN [3]; RE0001352.
RX PUBMED: 3244357.
RA Cato A. C. B., Heitlinger E., Ponta H., Klein-Hitpass L., Ryffel G. U., Bailly A., Rauch C., Milgrom E.
RT Estrogen and Progesterone Receptor-Binding Sites on the Chicken Vitellogenin II Gene: Synergism of Steroid Hormone Action
RL Mol. Cell. Biol. 8:5323-5330 (1988).
RN [4]; RE0001811.
RX PUBMED: 2983219.
RA von der Ahe D., Janich S., Scheidereit C., Renkawitz R., Schuetz G., Beato M.
RT Glucocorticoid and progesterone receptors bind the same sites in two hormonally regulated promoters
RL Nature 313:706-709 (1985).
RN [5]; RE0001817.
RX PUBMED: 3200320.
RA Guiochon-Mantel A., Loosfelt H., Ragot T., Bailly A., Atger M., Misrahi M., Perricaudet M., Milgrom E.
RT Receptors bound to antiprogestin form abortive complexes with hormone responsive elements
RL Nature 336:695-698 (1988).
RN [6]; RE0002033.
RX PUBMED: 3453115.
RA Jantzen K., Fritton H. P., Igo-Kemenes T., Espel E., Janich S., Cato A. C. B., Mugele K., Beato M.
RT Partial overlapping of binding sequences for steroid hormone receptors and DNaseI hypersensitive sites in the rabbit uteroglobin gene region
RL Nucleic Acids Res. 15:4535-4552 (1987).
RN [7]; RE0002332.
RX PUBMED: 2919163.
RA Schauer M., Chalepakis G., Willmann T., Beato M.
RT Binding of hormone accelerates the kinetics of glucocorticoid and progesterone receptor binding to DNA
RL Proc. Natl. Acad. Sci. USA 86:1123-1127 (1989).
RN [8]; RE0002360.
RX PUBMED: 3538016.
RA Loosfelt H., Atger M., Misrahi M., Guiochon-Mantel A., Meriel C., Logeat F., Benarous R., Milgrom E.
RT Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA
RL Proc. Natl. Acad. Sci. USA 83:9045-9049 (1986).
RN [9]; RE0002742.
RX PUBMED: 2162764.
RA Brueggemeier U., Rogge L., Winnacker E.-L., Beato M.
RT Nuclear factor I acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding
RL EMBO J. 9:2233-2239 (1990).
RN [10]; RE0003735.
RX PUBMED: 2736623.
RA Guichon-Mantel A., Loosfelt H., Lescop P., Sar S., Atger M., Perrot-Applanat M., Milgrom E.
RT Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers
RL Cell 57:1147-1154 (1989).
XX
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