AC T00856
XX
ID T00856
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DT 15.10.1992 (created); ewi.
DT 23.12.2013 (updated); msr.
CO Copyright (C), QIAGEN.
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FA TTF-1
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SY Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; Titf1; TTF-1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009206 Nkx2-1.
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HO NK-2 (Drosophila).
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CL C0053; NK-2/Nkx; 3.1.2.14.1.
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SF homeo domain is most closely related to that of NK-2 (82% identity) [2];
SF DNA-binding specificity is determined by the recognition helix plus additional parts of the HD [9];
SF essential for TTF-1 binding to CAAG instead of TAAT as most other HD factors is Gln-210 [12];
SF three-dimensional models of the TTF-1 HD suggest the presence of 4 alpha-helices, helix 3 and 4 immediately abutting [11];
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CP thyroid, lung [2].
CN brain, heart, intestine, kidney, liver, muscle, pituitary, spleen, stomach, testis, thymus [2].
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FF required for thyroid-specific gene expression [2];
FF DNA-binding capability may be regulated through oxidation of Cys-87 and Cys-363 [7];
FF expressed at the earliest stages of differentiation of thyroid and lung tissue [10];
FF in the lung, it is confined to bronchial epithelium at later stages;
FF expression occurs also in some restricted areas in the fetal brain (e. g., hypothalamic area of diencephalon, infundibulum, telencephalon at day 10.5 p.c.) [10];
FF may be a specific target of HOXB3 [13];
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IN T26748 Calsenilin; rat, Rattus norvegicus.
IN T10518 Pax-8; Mammalia.
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MX M01312 V$NKX21_01.
MX M00432 V$TITF1_Q3.
MX M02034 V$TTF1_Q5.
MX M03891 V$TTF1_Q5_01.
MX M00794 V$TTF1_Q6.
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BS R36425.
BS R34176.
BS R34177.
BS R04657.
BS R73086.
BS R73087.
BS R13201.
BS R13153.
BS R13174.
BS R32520.
BS R32524.
BS R32525.
BS R36426.
BS R13198.
BS R21416.
BS R01882.
BS R04318.
BS R04319.
BS R04320.
BS R59408.
BS R39894.
BS R02257.
BS R04645.
XX
DR TRANSPATH: MO000025222.
DR UniProtKB: P23441;
DR PDB: 1ftt.
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RN [1]; RE0000427.
RX PUBMED: 2583123.
RA Civitareale D., Lonigro R., Sinclair A. J., Di Lauro R.
RT A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter
RL EMBO J. 8:2537-2542 (1989).
RN [2]; RE0000467.
RX PUBMED: 1976511.
RA Guazzi S., Price M., de Felice M., Damante G., Mattei M., Di Lauro R.
RT Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity
RL EMBO J. 9:3631-3639 (1990).
RN [3]; RE0000696.
RX PUBMED: 1989905.
RA Avvedimento V. E., Musti A. M., Ueffing M., Obici S., Gallo A., Sanchez M., DeBrasi D., Gottesman M. E.
RT Reversible inhibition of a thyroid-specific trans-acting factor by Ras
RL Genes Dev. 5:22-28 (1991).
RN [4]; RE0001499.
RX PUBMED: 1922026.
RA Mizuno K., Gonzales F. J., Kimura S.
RT Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1
RL Mol. Cell. Biol. 11:4927-4993 (1991).
RN [5]; RE0004299.
RX PUBMED: 1508216.
RA Zannini M., Francis-Lang H., Plachov D., Di Lauro R.
RT Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters
RL Mol. Cell. Biol. 12:4230-4241 (1992).
RN [6]; RE0005199.
RX PUBMED: 8282100.
RA Viglino P., Fogolari F., Formisiano S., Bortolotti N., Damante G., Di Lauro R., Esposito G.
RT Structural study of rat thyroid transcription factor 1 homeodomain (TTF-1 HD) by nuclear magnetic resonance
RL FEBS Lett. 336:397-402 (1993).
RN [7]; RE0005200.
RX PUBMED: 7744853.
RA Arnone M. I., Zannini M., Di Lauro R.
RT The DNA binding actvity and the dimerization ability of the thyroid transcription factor I are redox regulated
RL J. Biol. Chem. 270:12048-12055 (1995).
RN [8]; RE0005201.
RX PUBMED: 7589789.
RA van Renterghem P. H. G., Dremier S., Vassar G., Christophe J.
RT Study of TTF1 gene expression in dog thyrocytes in primary culture
RL Mol. Cell. Endocrinol. 112:83-93 (1995).
RN [9]; RE0005202.
RX PUBMED: 1675795.
RA Damante G., Di Lauro R.
RT Several regions of Antennapedia and thyroid transcription factor 1 homeodomains contribute to DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:5388-5392 (1991).
RN [10]; RE0005203.
RX PUBMED: 1811929.
RA Lazzaro D., Price M., de Felice M., Di Lauro R.
RT The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
RL Development 113:1093-1104 (1991).
RN [11]; RE0005204.
RX PUBMED: 8105464.
RA Fogolari F., Esposito F., Viglino P., Damante G., Pastore A.
RT Homology model building of the thyroid transcription factor 1 homeodoamin
RL Protein Eng. 6:513-519 (1993).
RN [12]; RE0005205.
RX PUBMED: 7915030.
RA Damante G., Fabbro D., Pellizzari L., Civitareale D., Guazzi S., Polycarpou-Schwartz M., Cauci S., Quadrifoglio F., Formisano S., Di Lauro R.
RT Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain
RL Nucleic Acids Res. 22:3075-3083 (1994).
RN [13]; RE0005206.
RX PUBMED: 7913891.
RA Guazzi S., Lonigro R., Pintonello L., Boncinelli E., Di Lauro R., Mavilio F.
RT The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins
RL EMBO J. 13:3339-3347 (1994).
RN [14]; RE0049293.
RX PUBMED: 12441357.
RA Di Palma T., Nitsch R., Mascia A., Nitsch L., Di Lauro R., Zannini M.
RT The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription.
RL J. Biol. Chem. 278:3395-3402 (2003).
RN [15]; RE0049367.
RX PUBMED: 15181011.
RA Rivas M., Mellstrom B., Naranjo J. R., Santisteban P.
RT Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.
RL J. Biol. Chem. 279:33114-33122 (2004).
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