AC T01063
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ID T01063
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DT 24.02.1994 (created); ewi.
DT 31.10.2006 (updated); apk.
CO Copyright (C), QIAGEN.
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FA PEBP2alphaA2
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SY CBFA1; PEBP2alpha2; PEBP2alphaA; Runx2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005054 Runx2.
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CL C0029; runt.
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SZ 306 AA; 33.6 kDa (cDNA) (calc.).
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SQ MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQQQQ
SQ QQEAAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPS
SQ HWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFV
SQ GRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSD
SQ LGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLS
SQ QMTSLS
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SC Swiss-Prot#Q08775-4
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FT 2 232 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 91 225 
PF00853; Runt domain.
FT 93 221 
PS51062; RUNT.
FT 115 115 
C is protected by beta subunit against oxidational attack [3].
FT 124 124 
C is protected by beta subunit against oxidational attack [3].
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SF DNA-binding and heterodimerization;
SF direct interaction with c-Jun:c-Fos requires Runt domain and in addition C-terminus [4];
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CP thymus [2], testis [2], T lymphocytes [2]; osteoblasts [2].
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FF activator;
FF DNA-binding;
FF heterodimer: increased affinity;
FF expression is tissue type dependent [2];
FF believed to be involved in T-cell-specific gene expression [2];
FF osteoblast-specific factor, a major regulator of bone development;
FF physical and functional interactions with c-Jun:c-Fos in the bone-specific mmp13 gene regulation [4];
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IN T01065 PEBP2beta-isoform2; mouse, Mus musculus.
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MX M07276 V$AML3_Q3.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00731 V$OSF2_Q6.
MX M00984 V$PEBP_Q6.
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BS R14159.
BS R01222.
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DR TRANSPATH: MO000025372.
DR EMBL: D14637;
DR UniProtKB: Q08775-4; RUNX2_MOUSE.
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RN [1]; RE0002540.
RX PUBMED: 8341710.
RA Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K., Ito Y.
RT PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
RL Proc. Natl. Acad. Sci. USA 90:6859-6863 (1993).
RN [2]; RE0006071.
RX PUBMED: 7862157.
RA Satake M., Nomura S., Yamaguchi-Iwai Y., Takahama Y., Hashimoto Y., Niki M., Kitamura Y., Ito Y.
RT Expression of the Runt domain-encoding PEBP2alpha genes in T cells during thymic development
RL Mol. Cell. Biol. 15:1662-1670 (1995).
RN [3]; RE0006207.
RX PUBMED: 9169404.
RA Akamatsu Y., Ohno T., Hirota K., Kagoshima H., Yodoi J., Shigesada K.
RT Redox regulation of the DNA binding activity in transcription factor PEBP2
RL J. Biol. Chem. 272:14497-14500 (1997).
RN [4]; RE0023220.
RX PUBMED: 11274169.
RA Hess J., Porte D., Munz C., Angel P.
RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
RL J. Biol. Chem. 276:20029-20038 (2001).
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