TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01077 XX ID T01077 XX DT 24.02.1994 (created); ewi. DT 11.02.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA Abl XX SY Abelson tyrosine kinase; ABL; ABL1; bcr/abl; c-abl; c-abl oncogene 1, non-receptor tyrosine kinase; JTK7; p150; proto-oncogene tyrosine-protein kinase Abl; RP11-83J21.1; v-abl; v-abl Abelson murine leukemia viral oncogene homolog 1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004639 ABL1; HGNC: ABL1. XX CP (HeLa). XX FF nuclear tyrosine protein kinase; FF transforming variant p210bcr-abl is generated in chronic myelogenous leukemia (CML) as result of fusion of c-abl (chromosome 9) with bcr (chromosome 22) and does not bind to DNA [1]; XX IN T18369 NFAT5; Mammalia. IN T06138 p73; human, Homo sapiens. IN T04931 p73alpha; human, Homo sapiens. IN T25623 Rad9a; human, Homo sapiens. XX MX M08187 V$ABL1_01. XX BS R71809. BS R71810. BS R71811. BS R71812. BS R71813. BS R71814. BS R71815. BS R71816. BS R71817. BS R71818. BS R71819. BS R71820. BS R71821. BS R71822. BS R71823. BS R71824. BS R71825. BS R71826. BS R71827. BS R71828. BS R71829. BS R71830. BS R71831. BS R71832. BS R71833. BS R71834. BS R71835. BS R71836. BS R71837. BS R71838. BS R71839. BS R71840. BS R71841. BS R71842. BS R71843. BS R71844. BS R71845. BS R71846. BS R71847. BS R71848. BS R71849. BS R00635. XX DR TRANSPATH: MO000020628. DR UniProtKB: P00519; XX RN [1]; RE0000255. RX PUBMED: 1591775. RA Dikstein R., Heffetz D., Ben-Neriah Y., Shaul Y. RT c-abl has a sequence-specific enhancer binding acitivity RL Cell 69:751-757 (1992). RN [2]; RE0018855. RX PUBMED: 3021337. RA Shtivelman E., Lifshitz B., Gale R. P., Roe B. A., Canaani E. RT Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene RL Cell 47:277-284 (1986). RN [3]; RE0021142. RX PUBMED: 7565706. RA Welch P. J., Wang J. Y. J. RT Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms RL Mol. Cell. Biol. 15:5542-5551 (1995). RN [4]; RE0028516. RX PUBMED: 9162067. RA Sattler M., Salgia R., Shrikhande G., Verma S., Uemura N., Law S. F., Golemis E. A., Griffin J. D. RT Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). RL J. Biol. Chem. 272:14320-6 (1997). RN [5]; RE0036081. RX PUBMED: 12070014. RA Morena A., Riccioni S., Marchetti A., Polcini A. T., Mercurio A. M., Blandino G., Sacchi A., Falcioni R. RT Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells. RL Blood 100:96-106 (2002). RN [6]; RE0036112. RX PUBMED: 10866655. RA Kharbanda S., Pandey P., Yamauchi T., Kumar S., Kaneki M., Kumar V., Bharti A., Yuan Z. M., Ghanem L., Rana A., Weichselbaum R., Johnson G., Kufe D. RT Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. RL Mol. Cell. Biol. 20:4979-4989 (2000). RN [7]; RE0036125. RX PUBMED: 15448168. RA Yu D., Khan E., Khaleque M. A., Lee J., Laco G., Kohlhagen G., Kharbanda S., Cheng Y. C., Pommier Y., Bharti A. RT Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity. RL J. Biol. Chem. 279:51851-51861 (2004). RN [8]; RE0046415. RX PUBMED: 9820532. RA Kyono W. T., de Jong R., Park R. K., Liu Y., Heisterkamp N., Groffen J., Durden D. L. RT Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI) RL J. Immunol. 161:5555-63 (1998). RN [9]; RE0048129. RX PUBMED: 15886098. RA Hu H., Bliss J. M., Wang Y., Colicelli J. RT RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. RL Curr. Biol. 15:815-823 (2005). RN [10]; RE0048605. RX PUBMED: 15657060. RA Raina D., Pandey P., Ahmad R., Bharti A., Ren J., Kharbanda S., Weichselbaum R., Kufe D. RT c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. RL J. Biol. Chem. 280:11147-11151 (2005). RN [11]; RE0049323. RX PUBMED: 16702947. RA Dias S. S., Milne D. M., Meek D. W. RT c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF. RL Oncogene 25:6666 (2006). RN [12]; RE0049465. RX PUBMED: 16273093. RA Jones R. B., Gordus A., Krall J. A., MacBeath G. RT A quantitative protein interaction network for the ErbB receptors using protein microarrays. RL Nature 439:168-174 (2006). RN [13]; RE0049472. RX PUBMED: 16648821. RA di Bari M. G., Ciuffini L., Mingardi M., Testi R., Soddu S., Barila D. RT c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization. RL EMBO Rep. 7:727-733 (2006). RN [14]; RE0049750. RX PUBMED: 16631755. RA Lasfer M., Davenne L., Vadrot N., Alexia C., Sadji-Ouatas Z., Bringuier A. F., Feldmann G., Pessayre D., Reyl-Desmars F. RT Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor. RL FEBS Lett. 580:2547-2552 (2006). RN [15]; RE0064412. RX PUBMED: 19261608. RA Hirano I., Nakamura S., Yokota D., Ono T., Shigeno K., Fujisawa S., Shinjo K., Ohnishi K. RT Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms. RL J. Biol. Chem. 284:22155-22165 (2009). RN [16]; RE0070232. RX PUBMED: 20861316. RA Dudek S. M., Chiang E. T., Camp S. M., Guo Y., Zhao J., Brown M. E., Singleton P. A., Wang L., Desai A., Arce F. T., Lal R., Van Eyk J. E., Imam S. Z., Garcia J. G. RT Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. RL Mol. Biol. Cell 21:4042-4056 (2010). RN [17]; RE0024376. RX PUBMED: 10391250. RA Agami R., Blandino G., Oren M., Shaul Y. RT Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. RL Nature 399:809-813 (1999). RN [18]; RE0025276. RX PUBMED: 12628935. RA Yoshida K., Wang H. G., Miki Y., Kufe D. RT Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. RL Mol. Cell. Biol. 22:1431-1441 (2003). XX //