AC T01153
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ID T01153
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DT 26.04.1994 (created); ewi.
DT 23.03.2010 (updated); ada.
CO Copyright (C), QIAGEN.
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FA T3R-alpha2
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SY c-erbA-1; c-ErbA-alpha; c-ErbA-T; EAR-7; ear-7-2; EAR7; Nuclear receptor subfamily 1 group A member 1; T3R-alpha2; thyroid hormone receptor alpha; thyroid hormone receptor alpha2; TR.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004672 THRA; HGNC: THRA.
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CL C0002; CC (rec); 2.1.2.2.1.2.
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SZ 490 AA; 54.8 kDa (cDNA) (calc.).
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SQ MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
SQ TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
SQ AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
SQ QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
SQ ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
SQ ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
SQ PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
SQ GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
SQ EDLAGNAASP
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SC Swiss-Prot#P10827-1
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FT 50 123 
SM00399; c4gold.
FT 50 127 
PS51030; NUCLEAR_REC_DBD_2.
FT 51 128 
PF00105; Zinc finger, C4 type (two domains).
FT 83 431 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 220 378 
SM00430; holi.
FT 223 420 
PF00104; Ligand-binding domain of nuclear hormon.
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SF splice variant from THRA (c-arbA-1) gene [3];
SF conflict in protein sequence between EMBL entry #Y00479 and SWISSPROT entry #P21205: pos. 37 (S versus T), pos. 119 (A versus G);
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FF T3-binding with KD = 0.38 nM;
FF no heterodimers with RXR-alpha;
FF moderately inhibits positive regulation by T3R-alpha1 and T3R-beta, but does not affect negative regulation by T3R-alpha1 and T3R-beta;
FF probably competes for a co-factor required for positive alpha1/beta function;
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MX M01724 V$T3RALPHA_Q6.
MX M00963 V$T3R_Q6.
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BS R01465.
BS R04765.
BS R03102.
BS R03523.
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DR TRANSPATH: MO000025447.
DR UniProtKB: P10827-1;
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RN [1]; RE0001757.
RX PUBMED: 2284000.
RA Rentoumis A., Chatterjee V. K., Madison L. D., Datta S., Gallagher G. D., DeGroot L. J., Jameson J. L.
RT Negative and positive transcriptional regulation by thyroid hormone receptor isoforms
RL Mol. Endocrinol. 4:11522-1531 (1990).
RN [2]; RE0001853.
RX PUBMED: 2569164.
RA Sap J., Munoz A., Schmitt J., Stunnenberg H., Vennstroem B.
RT Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product
RL Nature 340:242 (1989).
RN [3]; RE0002102.
RX PUBMED: 1850510.
RA Laudet V., Begue A., Henry-Duthoit C., Joubel A., Martin P., Stehelin D., Saule S.
RT Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene
RL Nucleic Acids Res. 19:1105-1112 (1991).
RN [4]; RE0002642.
RX PUBMED: 3672126.
RA Benbrook D., Pfahl M.
RT A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library
RL Science 238:788-791 (1987).
RN [5]; RE0047529.
RX PUBMED: 11641275.
RA Potter G. B., Beaudoin GM 3. r. d., DeRenzo C. L., Zarach J. M., Chen S. H., Thompson C. C.
RT The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.
RL Genes Dev. 15:2687-2701 (2001).
RN [6]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [7]; RE0066219.
RX PUBMED: 18641393.
RA Grespin M. E., Bonamy G. M., Roggero V. R., Cameron N. G., Adam L. E., Atchison A. P., Fratto V. M., Allison L. A.
RT Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway.
RL J. Biol. Chem. 283:25576-25588 (2008).
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