AC T01200
XX
ID T01200
XX
DT 15.10.1992 (created); ewi.
DT 29.01.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA Egr-1
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SY Early Growth Responsive factor 1; EGR1; Krox-24; NGFI-A; TIS-8; zif268.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009956 Egr1.
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CL C0001; CH; 2.3.1.3.1.
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SF pI = 8.67;
SF 3 zinc finger motifs of C2H2-type;
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CP NGF induced PC-12 cells [12]; FSH stimulated rat granulosa cells treated with hCG or 8-Br-cAMP [9]; EGF stimulated 7C1T1 and 7C3H2 cells [8]; Angiotensin II treated WKY12-22 SMCs [15]; carotid arteries under stenosis [13].
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FF two subunits, encoded by an immediate-early response gene, involved in signal transduction;
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IN T02369 Nab1; rat, Rattus norvegicus.
XX
MX M00243 V$EGR1_01.
MX M01972 V$EGR1_02.
MX M07354 V$EGR1_Q3.
MX M01873 V$EGR1_Q6.
MX M08878 V$EGR_Q3.
MX M00807 V$EGR_Q6.
MX M00982 V$KROX_Q6.
XX
BS R17111.
BS R24698.
BS R24750.
BS R24969.
BS R24898.
BS R24693.
BS R24695.
BS R57906.
BS R24219.
BS R32043.
BS R24214.
BS R24957.
BS R24846.
BS R61490.
BS R04853.
BS R14693.
BS R20909.
BS R56594.
BS R34892.
BS R56604.
BS R56590.
BS R01614.
BS R01615.
BS R01616.
BS R56602.
BS R24208.
BS R56598.
BS R56580.
BS R26545.
BS R24447.
BS R21248.
BS R65948.
BS R34258.
BS R24256.
BS R20511.
BS R16446.
BS R24799.
BS R24149.
BS R31203.
BS R61603.
BS R40197.
BS R09547.
BS R29653.
BS R24288.
BS R21427.
BS R62331.
BS R34791.
BS R31114.
BS R31115.
BS R22637.
XX
DR TRANSPATH: MO000046040.
DR TRANSCOMPEL: C00356.
DR UniProtKB: P08154; EGR1_RAT.
XX
RN [1]; RE0001008.
RX PUBMED: 2118523.
RA Day M. L., Fahrner T. J., Ayken S., Milbrandt J.
RT The zinc finger protein NGFI-A exists in both nuclear and cytoplasmic forms in nerve growth factor-stimulated PC12 cells
RL J. Biol. Chem. 265:15253-15260 (1990).
RN [2]; RE0001470.
RX PUBMED: 1708092.
RA Suva L. J., Ernst M., Rodan G. A.
RT Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells
RL Mol. Cell. Biol. 11:2503-2510 (1991).
RN [3]; RE0002409.
RX PUBMED: 2510170.
RA Christy B., Nathans D.
RT DNA binding site of the growth factor-inducible protein Zif268
RL Proc. Natl. Acad. Sci. USA 86:8737-8741 (1989).
RN [4]; RE0002690.
RX PUBMED: 3672127.
RA Milbrandt J.
RT A nerve-growth factor-induced gene encodes a possible transcriptional regulatory factor
RL Science 238:797-799 (1987).
RN [5]; RE0002755.
RX PUBMED: 2109185.
RA Cao X., Koski R. A., Gashler A., McKiernan M., Morris C. F., Gaffney R., Hay R. V., Sukhatme V. P.
RT Identfication and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals
RL Mol. Cell. Biol. 10:1931-1939 (1990).
RN [6]; RE0002757.
RX PUBMED: 2113174.
RA Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., Charnay P.
RT The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator
RL Mol. Cell. Biol. 10:3456-3467 (1990).
RN [7]; RE0006735.
RX PUBMED: 7624335.
RA Russo M. W., Sevetson B. R., Milbrandt J.
RT Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription
RL Proc. Natl. Acad. Sci. USA 92:6873-6877 (1995).
RN [8]; RE0027015.
RX PUBMED: 10698497.
RA Scharnhorst V., Menke A. L., Attema J., Haneveld J. K., Riteco N., van Steenbrugge G. J., van der Eb A. J., Jochemsen A. G.
RT EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity.
RL Oncogene 19:791-800 (2000).
RN [9]; RE0029333.
RX PUBMED: 12021067.
RA Yoshino M., Mizutani T., Yamada K., Tsuchiya M., Minegishi T., Yazawa T., Kawata H., Sekiguchi T., Kajitani T., Miyamoto K.
RT Early growth response gene-1 regulates the expression of the rat luteinizing hormone receptor gene.
RL Biol. Reprod. 66:1813-9 (2002).
RN [10]; RE0050250.
RX PUBMED: 16611639.
RA Ng Y. P., Cheung Z. H., Ip N. Y.
RT STAT3 as a downstream mediator of Trk signaling and functions.
RL J. Biol. Chem. 281:15636-15644 (2006).
RN [11]; RE0050731.
RX PUBMED: 16223723.
RA Lo K. Y., Chin W. H., Ng Y. P., Cheng A. W., Cheung Z. H., Ip N. Y.
RT SLAM-associated protein as a potential negative regulator in Trk signaling.
RL J. Biol. Chem. 280:41744-41752 (2005).
RN [12]; RE0051517.
RX PUBMED: 16926281.
RA Tai T. C., Wong-Faull D. C., Claycomb R., Wong D. L.
RT Nerve growth factor regulates adrenergic expression.
RL Mol. Pharmacol. 70:1792-1801 (2006).
RN [13]; RE0053471.
RX PUBMED: 9974408.
RA Houston P., Dickson M. C., Ludbrook V., White B., Schwachtgen J. L., McVey J. H., Mackman N., Reese J. M., Gorman D. G., Campbell C., Braddock M.
RT Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1.
RL Arterioscler. Thromb. Vasc. Biol. 19:281-289 (1999).
RN [14]; RE0066665.
RX PUBMED: 18606818.
RA Luo Y., Lathia J., Mughal M., Mattson M. P.
RT SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons.
RL J. Biol. Chem. 283:24789-24800 (2008).
RN [15]; RE0053719.
RX PUBMED: 18272536.
RA Sanchez-Guerrero E., Midgley V. C., Khachigian L. M.
RT Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor-dependent Egr-1 transactivation.
RL Nucleic Acids Res. 36:1941-1951 (2008).
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