AC T01201
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ID T01201
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DT 15.10.1992 (created); ewi.
DT 28.02.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Pax-5
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SY B-cell specific activator protein; BSAP; BSAP/PAX-5, B-cell Specific Activating Protein; mPax-5; mPax5; Pax-5; PAX5.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006533 Pax5.
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HO TSAP (sea urchin).
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CL C0017; paired; 3.2.2.2.2.
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SF a few differences within the paired domains determine different DNA-binding sequence specificities between Pax-5 and Pax-6 [4];
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CP (pro-, pre-, mature B cells); tonsillar B-cells, located in the germinal centers and the mantle zone [10].
EX tonsil,B-lymphocyte,,adult; detectable; Northern blot; RNA (undefined); [10].
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FF Dedifferentiation of mature B cells to progenitors rescued T lymphopoiesis in the thymus of T-cell-deficient mice [9];
FF Complete loss of Pax5 in late B cells initiated lymphoma development [9];
FF Pax5 inactivation as well as prolonged cell survival is required for dedifferentiation of mature B cells in vivo [9];
FF Pax5 deletion in mice caused dedifferentiation of mature B cells from peripheral lymphoid organs to early uncommitted progenitors in the bone marrow (in vivo) [9];
FF Mature B cells lacking Pax5 developed aggressive lymphomas [9];
FF T cells derived by Pax5 deletion mediated dedifferentiation of B-cells are fully functional [9];
FF required for B-cell development [6];
FF represses Ig 3'alpha enhancer by preventing binding of an activator [7];
FF also required for correct early development of posterior midbrain [6];
FF expression positively regulated by E2A genes [2];
FF Pax-2, Pax-5 and Pax-8 show overlapping expression with the engrailed genes and bind as activators to the En-2 5' enhancer [8];
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MX M00143 V$PAX5_01.
MX M00144 V$PAX5_02.
MX M03577 V$PAX5_Q6.
MX M00808 V$PAX_Q6.
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BS R07229.
BS R07230.
BS R07231.
BS R07232.
BS R07233.
BS R07234.
BS R07235.
BS R07236.
BS R07237.
BS R07238.
BS R07239.
BS R07240.
BS R02128.
BS R38866.
BS R41906.
BS R38791.
BS R17086.
BS R29655.
BS R32735.
BS R13323.
BS R30718.
BS R26817.
BS R40159.
BS R40160.
BS R60633.
BS R27817.
BS R27820.
BS R14559.
BS R19752.
BS R04583.
BS R04584.
BS R01666.
BS R01667.
BS R01662.
BS R01663.
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DR TRANSPATH: MO000025492.
DR TRANSCOMPEL: C00228.
DR TRANSCOMPEL: C00239.
DR UniProtKB: Q02650;
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RN [1]; RE0002744.
RX PUBMED: 2116362.
RA Barberis A., Widenhorn K., Vitelli L., Busslinger M.
RT A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation
RL Genes Dev. 4:849-859 (1990).
RN [2]; RE0004022.
RX PUBMED: 8001125.
RA Bain G., Maandag E. C. R., Izon D. J., Amsen D., Kruisbeek A. M., Weintraub B. C., Krop I., Schlissel M. S., Feeney A. J., van Roon M., van der Falk M., te Riele H. P. J., Berns A., Murre C.
RT E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
RL Cell 79:885-892 (1994).
RN [3]; RE0004257.
RX PUBMED: 1685142.
RA Walther C., Guenet J. L., Simon D., Deutsch U., Jostes B., Goulding M. D., Plachov D., Balling R., Gruss P.
RT Pax: a murine multigene family of paired box-containing genes
RL Genomics 11:424-434 (1991).
RN [4]; RE0004263.
RX PUBMED: 7739566.
RA Czerny T., Busslinger M.
RT DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)
RL Mol. Cell. Biol. 15:2858-2871 (1995).
RN [5]; RE0004279.
RX PUBMED: 1516825.
RA Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
RT Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
RL Genes Dev. 6:1589-1607 (1992).
RN [6]; RE0004294.
RX PUBMED: 8001127.
RA Urbanek P., Wang Z.-Q., Fetka I., Wagner E. F., Busslinger M.
RT Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
RL Cell 79:901-912 (1994).
RN [7]; RE0004295.
RX PUBMED: 7777508.
RA Neurath M. F., Max E. E., Strober W.
RT Pax5 (BSAP) regulates the mrine immunoglobulin 3'a enhancer by suppressing binding of NF-aP, a protein that controls heavy chain transcription
RL Proc. Natl. Acad. Sci. USA 92:5336-5340 (1995).
RN [8]; RE0014313.
RX PUBMED: 8625814.
RA Song D. L., Chalepakis G., Gruss P., Joyner A. L.
RT Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene
RL Development 122:627-635 (1996).
RN [9]; RE0064882.
RX PUBMED: 17851532.
RA Cobaleda C., Jochum W., Busslinger M.
RT Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.
RL Nature 449:473-477 (2007).
RN [10]; RE0035360.
RX PUBMED: 12052884.
RA Lin K. I., Angelin-Duclos C., Kuo T. C., Calame K.
RT Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells.
RL Mol. Cell. Biol. 22:4771-4780 (2002).
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