AC T01278
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ID T01278
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DT 18.10.1994 (created); ewi.
DT 23.02.2005 (updated); elf.
CO Copyright (C), QIAGEN.
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FA HOXA7
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SY homeo box A7; Hox-1.1; HOXA7; m6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014476 Hoxa7.
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HO Ubx (Drosophila).
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CL C0006; homeo.
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SZ 229 AA; 25.7 kDa (cDNA) (calc.).
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SQ MSSSYYVNALFSKYTAGASLFQNAEPTSCSFAPNSQRSGYGPGAGAFASTVPGLYNVNSP
SQ LYQSPFASGYGLGADAYNLPCASYDQNIPGLCSDLAKGACDKADEGVLHGPAEASFRIYP
SQ WMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNR
SQ RMKWKKEHKDESQAPTAAPEDAVPSVSTAADKADEEEEEEEEEEEEEEE
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SC Swiss-Prot#P02830
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FT 127 187 
PS50071; HOMEOBOX_2.
FT 129 191 
SM00389; HOX_1.
FT 130 186 
PF00046; Homeobox domain.
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SF binds with relatively low affinity to homeo domain consensus sites (KD = 7 nM) [2];
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FF ubiquitous expression of human HOXA7 in transgenic mice is lethal in causing craniofacial abnormalities [5];
FF expressed in fetal kidney cortex [7] [6];
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MX M01108 V$HOXA7_01.
MX M01336 V$HOXA7_02.
MX M01394 V$HOXA7_03.
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BS R03849.
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DR TRANSPATH: MO000046041.
DR EMBL: M17192; MMHOX1.
DR EMBL: U15972; MM15972.
DR UniProtKB: P02830; HXA7_MOUSE.
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RN [1]; RE0001728.
RX PUBMED: 8264592.
RA Gross M. K., Gruss P.
RT Functional analysis of mouse Hoxa-7 in Saccharomyces cerevisiae: sequences outside the homeodomain base contact zone influence binding and activation
RL Mol. Cell. Biol. 14:238-254 (1994).
RN [2]; RE0003885.
RX PUBMED: 7911971.
RA Pellerin I., Schnabel C., Catron K. M., Abate C.
RT Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster
RL Mol. Cell. Biol. 14:4532-4545 (1994).
RN [3]; RE0003887.
RX PUBMED: 2885847.
RA Kessel M., Schulze F., Fibi M., Gruss P.
RT Primary structure and nuclear localization of a murine homeodomain protein
RL Proc. Natl. Acad. Sci. USA 84:5306-5310 (1987).
RN [4]; RE0003888.
RX PUBMED: 2986010.
RA Colberg-Poley A. M., Voss S. D., Chowdhury K., Gruss P.
RT Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells
RL Nature 314:713-718 (1985).
RN [5]; RE0003894.
RX PUBMED: 2568891.
RA Balling R., Mutter G., Gruss P., Kessel M.
RT Cranofacial abnormailities induced by ectopic expression of the homeobox gene HOX-1.1 in transgenic mice
RL Cell 58:337-347 (1989).
RN [6]; RE0006759.
RX PUBMED: 7538068.
RA Knittel T., Kessel M., Kim M. H., Gruss P.
RT A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development
RL Development 121:1077-1088 (1995).
RN [7]; RE0014517.
RA Davies J. A., Brandli A. W.
RT The Kidney Development Database; URL: http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html
RL Internet : (1997).
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