AC T01403
XX
ID T01403
XX
DT 27.10.1992 (created); ewi.
DT 01.09.2009 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA GABP-beta1
XX
SY GA binding protein beta subunit; GABP-beta; GABP-beta1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004134 Gabpb1.
XX
SZ 382 AA; 41.3 kDa (cDNA) (calc.), 46 kDa (SDS), 82 kDa (GF, sedim.) [2]
XX
SQ MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHFSTTEVLLRA
SQ GVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
SQ ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
SQ PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVATEEVVT
SQ AESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGMGQPIIVTMPDGQQVLTVPAT
SQ DIAEETVISEEPPAKRQCMEIIESRVECAEIEEREALQKQLDEANREAQKYRQQLLKKEQ
SQ EAEAYRQKLEAMTRIQTNKEAV
XX
SC Swiss-Prot#Q00420-3
XX
FT 1 33 
essential for DNA-binding and for GABP-alpha interaction [2].
FT 35 308 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 37 66 
SM00248; ANK_2a.
FT 37 69 
PF00023; Ankyrin repeat.
FT 37 69 
PS50088; ANK_REPEAT.
FT 37 156 
PS50297; ANK_REP_REGION.
FT 70 99 
SM00248; ANK_2a.
FT 70 102 
PF00023; Ankyrin repeat.
FT 70 102 
PS50088; ANK_REPEAT.
FT 103 132 
SM00248; ANK_2a.
FT 103 135 PF00023; Ankyrin repeat.
FT 103 135 PS50088; ANK_REPEAT.
FT 136 166 SM00248; ANK_2a.
XX
SF ankyrin-repeats;
SF forms homodimers and heterotetramers with GABP-alpha [2];
SF highly specific interaction with ETS-domain of GABP-alpha, not mimicked by other ETS-factors [3];
XX
CP abundant in thymus; kidney, liver, muscle; much less in uterus, testis, brain, spleen, gut.
XX
FF might interact with membrane-bound proteins through the ankyrin repeats;
XX
IN T01402 GABP-alpha; mouse, Mus musculus.
XX
MX M00971 V$ETS_Q6.
MX M01876 V$GABPBETA_Q3.
MX M00341 V$GABP_B.
XX
BS R26932.
XX
DR TRANSPATH: MO000046042.
DR EMBL: M74516; MMGAB.
DR UniProtKB: Q00420-3;
XX
RN [1]; RE0002667.
RX PUBMED: 1876836.
RA LaMarco K., Thompson C. C., Byers B. P., Walton E. M., McKnight S. L.
RT Identification of Ets- and Notch-related subunits in GA binding proteins
RL Science 253:789-792 (1991).
RN [2]; RE0002668.
RX PUBMED: 1876833.
RA Thompson C. C., Brown T. A., McKnight S. L.
RT Convergence of Ets- and Notch-related structural motifs in a heteromeric DNA binding complex
RL Science 253:762-768 (1991).
RN [3]; RE0005362.
RX PUBMED: 1340465.
RA Brown T. A., McKnight S. L.
RT Specificities of protein-protein and protein-DNA interaction of GABPalpha and two newly defined ets-related proteins
RL Genes Dev. 6:2502-2512 (1992).
XX
//