AC T01404
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ID T01404
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DT 27.10.1992 (created); ewi.
DT 07.09.2009 (updated); pro.
CO Copyright (C), QIAGEN.
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FA GABP-beta2
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SY GA binding protein beta subunit; GABP-beta; GABP-beta2; NRF-2beta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004134 Gabpb1.
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SZ 347 AA; 36.9 kDa (cDNA) (calc.), 46 kDa (GF, sedim.) [2]
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SQ MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHFSTTEVLLRA
SQ GVSRDARTKVDRTPLHMAASEGHANIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVV
SQ ELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAAT
SQ PQFIIGPGGVVNLTDETGVSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVATEEVVT
SQ AESVDGAIQQVVSSGGQQVITIVTDGIQLGNLHSIPTSGMGQPIIVTMPDGQQVLTVPAT
SQ DIAEETVISEEPPAKRQCMEIIESRVECAEIEVRSLIPGVFCCSHPK
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SC Swiss-Prot#Q00420-1
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FT 1 33 
essential for DNA-binding and for GABP-alpha interaction [2].
FT 35 308 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 37 66 
SM00248; ANK_2a.
FT 37 69 
PF00023; Ankyrin repeat.
FT 37 69 
PS50088; ANK_REPEAT.
FT 37 156 
PS50297; ANK_REP_REGION.
FT 70 99 
SM00248; ANK_2a.
FT 70 102 
PF00023; Ankyrin repeat.
FT 70 102 
PS50088; ANK_REPEAT.
FT 103 132 
SM00248; ANK_2a.
FT 103 135 PF00023; Ankyrin repeat.
FT 103 135 PS50088; ANK_REPEAT.
FT 136 166 SM00248; ANK_2a.
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SF DNA sequence M74517 codes for a protein with an additional Val (V230 -> VV);
SF highly specific interaction with ETS-domain of GABP-alpha, not mimicked by other ETS-factors;
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CP abundant in thymus; kidney, liver, muscle; much less in uterus, testis, brain, spleen, gut.
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FF might interact with membrane-bound proteins through the ankyrin-repeats;
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IN T01402 GABP-alpha; mouse, Mus musculus.
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MX M00971 V$ETS_Q6.
MX M01876 V$GABPBETA_Q3.
MX M00341 V$GABP_B.
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DR TRANSPATH: MO000046043.
DR EMBL: M74517; MMGAC.
DR UniProtKB: Q00420-1;
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RN [1]; RE0002667.
RX PUBMED: 1876836.
RA LaMarco K., Thompson C. C., Byers B. P., Walton E. M., McKnight S. L.
RT Identification of Ets- and Notch-related subunits in GA binding proteins
RL Science 253:789-792 (1991).
RN [2]; RE0002668.
RX PUBMED: 1876833.
RA Thompson C. C., Brown T. A., McKnight S. L.
RT Convergence of Ets- and Notch-related structural motifs in a heteromeric DNA binding complex
RL Science 253:762-768 (1991).
RN [3]; RE0005362.
RX PUBMED: 1340465.
RA Brown T. A., McKnight S. L.
RT Specificities of protein-protein and protein-DNA interaction of GABPalpha and two newly defined ets-related proteins
RL Genes Dev. 6:2502-2512 (1992).
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