AC T01476
XX
ID T01476
XX
DT 02.05.1995 (created); ewi.
DT 07.02.2006 (updated); vma.
CO Copyright (C), QIAGEN.
XX
FA Abd-B
XX
SY Abdominal-B.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G021776 Abd-B.
XX
CL C0006; homeo.
XX
SZ 491 AA; 55.0 kDa (gene) (calc.).
XX
SQ MQQHHLQQQQQQQQQQEQQHLQEQQQHLQQLHHHAHHHLPQPLHTTSHHHSAHPHLQQQQ
SQ QQQQHAVVASSPSVLQQQQQQSTPTTHSTPTHAVMYEDPPPVPLVAVQQQHLPAPQQQQQ
SQ LQQQQQQQQQQLATTPVAGALSPAQTPTGPSAQQQQHLTSPHHQQLPQQQTPNSVPVRSS
SQ NLQQQQQQQNAAVAPGQTQIVAPTTASVSPSSVSSQKEDINMSIQLAPLHIPAIRAGPGF
SQ ETDTSAAVKRHTAHWAYNDEGFNQHYGSGYYDRKHMFAYPYPETQFPVGQYWGPNYRPDQ
SQ TTSAAAAAAYMNEADGHVSAAARQSVEGTSTSSYEPPTYSSPGGLRGYPSENYSSSGASG
SQ GLSVGAVGPCTPNPGLHEWTGQVSVRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELAR
SQ NLQLTERQVKIWFQNRRMKNKKNSQRQANQQNNNNNSSSNHNHAQATQQHHSGHHLNLSL
SQ NMGHHAAKMHQ
XX
SC Swiss-Prot#P09087
XX
FT 56 65 
PF00904; Involucrin repeat.
FT 63 339 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 383 443 
PS50071; HOMEOBOX_2.
FT 385 447 
SM00389; HOX_1.
FT 386 442 
PF00046; Homeobox domain.
XX
SF prefers a TTAT core sequence to bind to instead of TAAT as most other homeo domain factors [1];
SF DNA-binding specificity is mainly determined by the N-terminal arm of the homeo domain [1];
XX
FF activator in the eighth abdominal segment of early- and mid-stage embryos [3];
FF homeotic selector gene;
FF required together with Ems, which it activates, to induce formation of filzkoerper primordia [3];
FF expression is repressed by Hunchback and Krueppel, which define the anterior border, and Knirps, which is responsible for the graded expression across to the expression zone [4];
FF region-specific silencing is mediated by three region of the Abd-B gene, requiring Hunchback and Polycomb [4];
FF specific control regions govern expression in the different parasegments [5];
XX
MX M00090 I$ABDB_01.
MX M02283 I$ABDB_02.
MX M07754 I$ABDB_03.
MX M07755 I$ABDB_04.
MX M07756 I$ABDB_05.
MX M07757 I$ABDB_06.
MX M01094 I$ABDB_Q6.
XX
BS R09578.
BS R17402.
BS R17403.
BS R17405.
BS R17406.
BS R17408.
BS R17410.
BS R17411.
BS R02507.
XX
DR TRANSPATH: MO000025698.
DR EMBL: M21173;
DR EMBL: X16134;
DR UniProtKB: P09087;
DR FLYBASE: FBgn0000015; Abd-B.
XX
RN [1]; RE0002965.
RX PUBMED: 7914870.
RA Ekker S. C., Jackson D. G., von Kessler D. P., Sun B. I., Young K. E., Beachy P. A.
RT The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
RL EMBO J. 13:3551-3560 (1994).
RN [2]; RE0004957.
RX PUBMED: 2575066.
RA Celniker S. E., Keelan D. J., Lewis E. B.
RT The molecular genetics of the bithorax complex of Drosophilia: characterisation of the products of the Abd-B domain
RL Genes Dev. 3:1424-1436 (1989).
RN [3]; RE0004958.
RX PUBMED: 8094700.
RA Jones B., McGinnis W.
RT The regulation of spiracles by Abdominal-B mediates an abdominal segment identity function
RL Genes Dev. 7:229-240 (1993).
RN [4]; RE0004959.
RX PUBMED: 8096812.
RA Busturia A., Bienz M.
RT Silencers in Abdominal-B, a homeotic Drosophila gene
RL EMBO J. 12:1415-1425 (1993).
RN [5]; RE0004960.
RX PUBMED: 7915032.
RA Karch F., Galloni M., Sipos L., Gausz J., Gyurkovics H., Schedl P.
RT MCP and Fab-7: molecular analysis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster
RL Nucleic Acids Res. 22:3138-3146 (1994).
RN [6]; RE0015328.
RX PUBMED: 7902124.
RA Kalionis B., O'Farrell P. H.
RT A universal target sequence is bound in vitro by diverse homeodomains
RL Mech. Dev. 43:57-70 (1993).
XX
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