TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01483 XX ID T01483 XX DT 04.05.1995 (created); ewi. DT 31.08.2011 (updated); mkl. CO Copyright (C), QIAGEN. XX FA PRX-2 XX SY PRRX2; Prx-2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006594 Prrx2. XX CL C0006; homeo; XX SF Paired-type homeo domain except Gln-50, which is indicative for Antp-type HDs; SF also, the PRX-2 DNA-binding specificity resembles that of Antp-type homeo domain factors [1]; SF KD for binding to an optimal sequence is 60 nM [1]; SF closely related to MHox [1]; SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [4]; XX CP embryonic mesoderm; mesenchyme of head, limb, trunk, somites, sclerotomes, heart [3]. CN CNS, PNS, splanchnopleure, endodermal derivatives [3]. XX FF no position-specific expression along the body axis [3]; FF for expression in teeth, see [5]; XX IN T14088 Sox-8; mouse, Mus musculus. XX MX M02188 V$PRRX2_03. MX M02115 V$PRX2_Q2. MX M00099 V$S8_01. MX M01376 V$S8_02. XX BS R04719. XX DR TRANSPATH: MO000025704. DR UniProtKB: Q06348; XX RN [1]; RE0002970. RX PUBMED: 7901837. RA de Jong R., van der Heijden J., Meijlink F. RT DNA-binding specificity of the S8 homeodomain RL Nucleic Acids Res. 21:4711-4720 (1993). RN [2]; RE0003965. RX PUBMED: 2901346. RA Kongsuwan K., Webb E., Housiaux P., Adams J. M. RT Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages RL EMBO J. 7:2131-2138 (1988). RN [3]; RE0005191. RX PUBMED: 1680375. RA Opstelten D.-J., Vogels R., Robert B., Kalkhoven E., Zwartkruis F., de Laaf L., Destree O. H., Deschamps J., Lawson K. A., Meijlink F. RT The mouse homeobox gene, S8, is expressed during embryogenesis predominantly in mesenchyme RL Mech. Dev. 34:29-41 (1991). RN [4]; RE0014693. RX PUBMED: 9096350. RA Furukawa T., Kozak C. A., Cepko C. L. RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997). RN [5]; RE0014814. RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I. RT Gene expression in tooth (WWW database); URL: RL Internet : (1996). RN [6]; RE0048308. RX PUBMED: 16582099. RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M. RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. RL Nucleic Acids Res. 34:1735-1744 (2006). XX //