AC T01491
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ID T01491
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DT 09.05.1995 (created); ewi.
DT 01.06.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA IRF-2
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SY INTERFERON REGULATORY FACTOR 2; IRF2; PRDI-BFc; PRDI-BFi.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001056 IRF2; HGNC: IRF2.
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CL C0022; trp; 3.5.3.0.2.
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SF highly similar to IRF-2;
SF C-terminally truncated forms observed after virus-inducible proteolysis [2];
SF IAD2 domain is conserved between IRF-1 and IRF-2, but is different in other family members [5];
SF IAD2 is responsible for protein-protein interactions [5];
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FF negative constitutive regulator of interferon-beta expression;
FF same DNA binding specificity as IRF-1;
FF truncated forms are less effective repressors than full-length IRF-2 [2];
FF enhanced levels after interferon-induction through IRF-1 binding to a ISRE within the IRF-2 promoter [3] [4];
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MX M00063 V$IRF2_01.
MX M08775 V$IRF2_03.
MX M01882 V$IRF2_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R26855.
BS R04222.
BS R26786.
BS R26813.
BS R35884.
BS R19521.
BS R73492.
BS R30511.
BS R59351.
BS R34156.
BS R13380.
BS R13141.
BS R26496.
BS R68433.
BS R13560.
BS R20802.
BS R58818.
BS R33574.
BS R33607.
BS R26274.
BS R14492.
BS R26805.
BS R26810.
BS R26812.
BS R26823.
BS R58177.
BS R19557.
BS R19558.
BS R27050.
BS R23922.
BS R27143.
BS R26784.
BS R26785.
BS R27105.
BS R26477.
BS R27117.
BS R20267.
BS R13011.
BS R57040.
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DR TRANSPATH: MO000007691.
DR UniProtKB: P14316;
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RN [1]; RE0002927.
RX PUBMED: 8168491.
RA Harroch S., Revel M., Chebath J.
RT Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA
RL EMBO J. 13:1942-1949 (1994).
RN [2]; RE0003191.
RX PUBMED: 1630448.
RA Palombella V. J., Maniatis T.
RT Inducible processing of interferon regulatory factor-2
RL Mol. Cell. Biol. 12:3325-3336 (1992).
RN [3]; RE0003473.
RX PUBMED: 7507207.
RA Harada H., Takahashi E.-I., Itoh S., Harada K., Hori T.-A., Taniguchi T.
RT Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system
RL Mol. Cell. Biol. 14:1500-1509 (1994).
RN [4]; RE0003474.
RX PUBMED: 8106512.
RA Cha Y., Deisseroth A. B.
RT Human interferon regulatory factor 1 gene. Intron-exon organization and functional analysis of 5'-flanking region
RL J. Biol. Chem. 269:5279-5287 (1994).
RN [5]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [6]; RE0019563.
RX PUBMED: 2813069.
RA ITOH S., HARADA H., FUJITA T., MIMURA T., TANIGUCHI T.
RT Sequence of a cDNA coding for human IRF-2.
RL Nucleic Acids Res. 17:8372-8372 (1989).
RN [7]; RE0065158.
RX PUBMED: 18281489.
RA Wang Y., Liu D., Chen P., Koeffler H. P., Tong X., Xie D.
RT Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers.
RL Cancer Res. 68:1136-1143 (2008).
RN [8]; RE0065187.
RX PUBMED: 17237409.
RA Choi J. C., Holtz R., Petroff M. G., Alfaidy N., Murphy S. P.
RT Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway.
RL J. Immunol. 178:1598-1607 (2007).
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