TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01491 XX ID T01491 XX DT 09.05.1995 (created); ewi. DT 01.06.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA IRF-2 XX SY INTERFERON REGULATORY FACTOR 2; IRF2; PRDI-BFc; PRDI-BFi. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001056 IRF2; HGNC: IRF2. XX CL C0022; trp; XX SF highly similar to IRF-2; SF C-terminally truncated forms observed after virus-inducible proteolysis [2]; SF IAD2 domain is conserved between IRF-1 and IRF-2, but is different in other family members [5]; SF IAD2 is responsible for protein-protein interactions [5]; XX FF negative constitutive regulator of interferon-beta expression; FF same DNA binding specificity as IRF-1; FF truncated forms are less effective repressors than full-length IRF-2 [2]; FF enhanced levels after interferon-induction through IRF-1 binding to a ISRE within the IRF-2 promoter [3] [4]; XX MX M00063 V$IRF2_01. MX M08775 V$IRF2_03. MX M01882 V$IRF2_Q6. MX M08887 V$IRF_Q4. MX M00772 V$IRF_Q6. MX M00972 V$IRF_Q6_01. XX BS R26855. BS R04222. BS R26786. BS R26813. BS R35884. BS R19521. BS R73492. BS R30511. BS R59351. BS R34156. BS R13380. BS R13141. BS R26496. BS R68433. BS R13560. BS R20802. BS R58818. BS R33574. BS R33607. BS R26274. BS R14492. BS R26805. BS R26810. BS R26812. BS R26823. BS R58177. BS R19557. BS R19558. BS R27050. BS R23922. BS R27143. BS R26784. BS R26785. BS R27105. BS R26477. BS R27117. BS R20267. BS R13011. BS R57040. XX DR TRANSPATH: MO000007691. DR UniProtKB: P14316; XX RN [1]; RE0002927. RX PUBMED: 8168491. RA Harroch S., Revel M., Chebath J. RT Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA RL EMBO J. 13:1942-1949 (1994). RN [2]; RE0003191. RX PUBMED: 1630448. RA Palombella V. J., Maniatis T. RT Inducible processing of interferon regulatory factor-2 RL Mol. Cell. Biol. 12:3325-3336 (1992). RN [3]; RE0003473. RX PUBMED: 7507207. RA Harada H., Takahashi E.-I., Itoh S., Harada K., Hori T.-A., Taniguchi T. RT Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system RL Mol. Cell. Biol. 14:1500-1509 (1994). RN [4]; RE0003474. RX PUBMED: 8106512. RA Cha Y., Deisseroth A. B. RT Human interferon regulatory factor 1 gene. Intron-exon organization and functional analysis of 5'-flanking region RL J. Biol. Chem. 269:5279-5287 (1994). RN [5]; RE0017830. RX PUBMED: 10586038. RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z. RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. RL J. Immunol. 163:6468-6478 (1999). RN [6]; RE0019563. RX PUBMED: 2813069. RA ITOH S., HARADA H., FUJITA T., MIMURA T., TANIGUCHI T. RT Sequence of a cDNA coding for human IRF-2. RL Nucleic Acids Res. 17:8372-8372 (1989). RN [7]; RE0065158. RX PUBMED: 18281489. RA Wang Y., Liu D., Chen P., Koeffler H. P., Tong X., Xie D. RT Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. RL Cancer Res. 68:1136-1143 (2008). RN [8]; RE0065187. RX PUBMED: 17237409. RA Choi J. C., Holtz R., Petroff M. G., Alfaidy N., Murphy S. P. RT Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway. RL J. Immunol. 178:1598-1607 (2007). XX //