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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01525 XX ID T01525 XX DT 15.06.1995 (created); ewi. DT 21.08.2006 (updated); sri. CO Copyright (C), QIAGEN. XX FA HSF1short XX SY heat shock (transcription) factor 1; heat shock factor protein 1; heat shock transcription factor 1; HSF 1; HSF-1; HSTF 1; mHSF1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009138 Hsf1. XX CL C0050; HSF. XX SZ 503 AA; 54.9 kDa (cDNA) (calc.). XX SQ MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY SQ FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT SQ SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA SQ QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY SQ SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE SQ PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL SQ PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDIQELLSPQ SQ EPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDY SQ TDDPTISLLTGTEPHKAKDPTVS XX SC Swiss-Prot#P38532-2 XX FT 14 118 SM00415; HSF. FT 16 120 DNA-binding domain [1]. FT 16 211 PF00447; HSF-type DNA-binding. FT 18 85 PS50140; HSF_ETS. FT 137 212 hydrophobic heptad repeat [1]. FT 246 503 PF06546; Vertebrate heat shock transcription fact. FT 378 407 leucine zipper motif [1]. XX SF for the long isoform see HSF1long T05813; XX FF mediates heat shock responses; FF induced by following stress factors: heat, hydrogen peroxide, osmotic stress [2]; FF HSF1 granule formation requires both the DNA binding and trimerization domains [3]; XX MX M00146 V$HSF1_01. MX M07259 V$HSF1_Q5. MX M07459 V$HSF1_Q5_01. MX M01023 V$HSF1_Q6. XX DR TRANSPATH: MO000006879. DR EMBL: BC013716; DR EMBL: X61753; DR UniProtKB: P38532-2; XX RN [1]; RE0023684. RA Morimoto R., Jurivich D., Kroeger P., Mathur S., Murphy S., Nakai A., Sarge K., Abravaya K., Sistonen L. RT Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors RL The Biology of Heat Shock Proteins and Molecular Chaperones :417-455 (1994). RN [2]; RE0023693. RX PUBMED: 10547058. RA Nakai A. RT New aspects in the vertebrate heat shock factor system: Hsf3 and Hsf4. RL Cell Stress Chaperones 4:86-93 (1999). RN [3]; RE0024938. RX PUBMED: 11877455. RA Jolly C., Konecny L., Grady D. L., Kutskova Y. A., Cotto J. J., Morimoto R. I., Vourc'h C. RT In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress. RL J. Cell Biol. 156:775-781 (2002). RN [4]; RE0048043. RX PUBMED: 9499401. RA Shi Y., Mosser D. D., Morimoto R. I. RT Molecular chaperones as HSF1-specific transcriptional repressors. RL Genes Dev. 12:654-666 (1998). XX //