AC T01525
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ID T01525
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DT 15.06.1995 (created); ewi.
DT 21.08.2006 (updated); sri.
CO Copyright (C), QIAGEN.
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FA HSF1short
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SY heat shock (transcription) factor 1; heat shock factor protein 1; heat shock transcription factor 1; HSF 1; HSF-1; HSTF 1; mHSF1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009138 Hsf1.
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CL C0050; HSF.
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SZ 503 AA; 54.9 kDa (cDNA) (calc.).
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SQ MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
SQ FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SQ SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
SQ QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SQ SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
SQ PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
SQ PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDIQELLSPQ
SQ EPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDY
SQ TDDPTISLLTGTEPHKAKDPTVS
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SC Swiss-Prot#P38532-2
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FT 14 118 
SM00415; HSF.
FT 16 120 
DNA-binding domain [1].
FT 16 211 
PF00447; HSF-type DNA-binding.
FT 18 85 
PS50140; HSF_ETS.
FT 137 212 
hydrophobic heptad repeat [1].
FT 246 503 
PF06546; Vertebrate heat shock transcription fact.
FT 378 407 
leucine zipper motif [1].
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SF for the long isoform see HSF1long T05813;
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FF mediates heat shock responses;
FF induced by following stress factors: heat, hydrogen peroxide, osmotic stress [2];
FF HSF1 granule formation requires both the DNA binding and trimerization domains [3];
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MX M00146 V$HSF1_01.
MX M07259 V$HSF1_Q5.
MX M07459 V$HSF1_Q5_01.
MX M01023 V$HSF1_Q6.
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DR TRANSPATH: MO000006879.
DR EMBL: BC013716;
DR EMBL: X61753;
DR UniProtKB: P38532-2;
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RN [1]; RE0023684.
RA Morimoto R., Jurivich D., Kroeger P., Mathur S., Murphy S., Nakai A., Sarge K., Abravaya K., Sistonen L.
RT Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors
RL The Biology of Heat Shock Proteins and Molecular Chaperones :417-455 (1994).
RN [2]; RE0023693.
RX PUBMED: 10547058.
RA Nakai A.
RT New aspects in the vertebrate heat shock factor system: Hsf3 and Hsf4.
RL Cell Stress Chaperones 4:86-93 (1999).
RN [3]; RE0024938.
RX PUBMED: 11877455.
RA Jolly C., Konecny L., Grady D. L., Kutskova Y. A., Cotto J. J., Morimoto R. I., Vourc'h C.
RT In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress.
RL J. Cell Biol. 156:775-781 (2002).
RN [4]; RE0048043.
RX PUBMED: 9499401.
RA Shi Y., Mosser D. D., Morimoto R. I.
RT Molecular chaperones as HSF1-specific transcriptional repressors.
RL Genes Dev. 12:654-666 (1998).
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