TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01577 XX ID T01577 XX DT 24.11.1995 (created); ewi. DT 15.05.2013 (updated); uat. CO Copyright (C), QIAGEN. XX FA STAT4 XX SY signal transducer and activator of transcription 4. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004626 STAT4; HGNC: STAT4. XX CL C0039; STAT; XX FF specifically induced by IL-12 [4] [1]; FF STAT4 binds within the IL-2 responsive element of myc upon tyrosine phosphorylation by Jak2 [5]; XX IN T01577 STAT4; human, Homo sapiens. XX MX M00498 V$STAT4_01. MX M01666 V$STAT4_Q4. MX M02117 V$STAT4_Q5. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R31033. BS R30825. BS R28469. BS R25927. BS R25930. BS R36238. BS R36240. BS R36241. BS R36242. BS R25909. BS R11154. BS R11155. BS R26378. BS R25470. BS R25471. BS R16930. BS R13241. BS R13242. BS R39482. BS R31000. BS R56044. BS R04650. XX DR TRANSPATH: MO000019621. DR TRANSCOMPEL: C00372. DR UniProtKB: Q14765; XX RN [1]; RE0003483. RX PUBMED: 7760829. RA Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., Cleveland J. L., Pierce J. H., Keegan A. D., Nelms K., Paul W. E., Ihle J. N. RT Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosporylated in responses to IL-4 and IL-3 but are not required for mitogenesis RL Mol. Cell. Biol. 15:3336-3343 (1995). RN [2]; RE0003513. RX PUBMED: 8085155. RA Hou J., Schindler U., Henzel W. J., Ho T. C., Brasseur M., McKnight S. L. RT An interleukin-4-induced transcription factor: IL-4 stat RL Science 265:1701-1706 (1994). RN [3]; RE0006297. RX PUBMED: 8670419. RA Xu X., Sun Y. L., Hoey T. RT Cooperative DNA binding and sequence-selective recognition conferred by the STAT Amio-Terminal domain RL Science 273:794-797 (1996). RN [4]; RE0022201. RX PUBMED: 10358173. RA Galon J., Sudarshan C., Ito S., Finbloom D., O Shea J. J. RT IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. RL J. Immunol. 162:7256-7262 (1999). RN [5]; RE0022240. RX PUBMED: 10702306. RA Grigorieva I., Grigoriev V. G., Rowney M. K., Hoover R. G. RT Regulation of c-myc transcription by interleukin-2 (IL-2). Identification of a novel IL-2 response element interacting with STAT-4. RL J. Biol. Chem. 275:7343-7350 (2000). RN [6]; RE0032828. RX PUBMED: 11801527. RA Miscia S., Marchisio M., Grilli A., Di Valerio V., Centurione L., Sabatino G., Garaci F., Zauli G., Bonvini E., Di Baldassarre A. RT Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells. RL Cell Growth Differ. 13:13-8 (2002). RN [7]; RE0043317. RX PUBMED: 12023369. RA Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K. P., Vega F., To W., Wagner J., O'Farrell A. M., McClanahan T., Zurawski S., Hannum C., Gorman D., Rennick D. M., Kastelein R. A., de Waal Malefyt R., Moore K. W. RT A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R RL J. Immunol. 168:5699-708 (2002). RN [8]; RE0043858. RX PUBMED: 11114383. RA Oppmann B., Lesley R., Blom B., Timans J. C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K., Zonin F., Vaisberg E., Churakova T., Liu M., Gorman D., Wagner J., Zurawski S., Liu Y., Abrams J. S., Moore K. W., Rennick D., de Waal-Malefyt R., Hannum C., Bazan J. F., Kastelein R. A. RT Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 RL Immunity 13:715-25 (2000). RN [9]; RE0064288. RX PUBMED: 19104082. RA Sattler A., Wagner U., Rossol M., Sieper J., Wu P., Krause A., Schmidt W. A., Radmer S., Kohler S., Romagnani C., Thiel A. RT Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. RL Blood 113:1948-1956 (2009). RN [10]; RE0069503. RX PUBMED: 20974963. RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J. RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010). XX //