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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01670 XX ID T01670 XX DT 15.02.1996 (created); ewi. DT 19.02.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA rfx3 XX SY bA32F11.1; MGC87155; regulatory factor X, 3 (influences HLA class II expression); RFX3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004681 RFX3; HGNC: RFX3. XX CL C0023; fork head; 3.3.3.0.3. XX SF member of winged-helix class of helix-turn-helix superclass of factors [2]; SF can bind DNA as a homodimer or heterodimer with RFX1 [3]; XX CP ubiquitous; highest level in testis [1]; highly expressed in primary eosinophils [3] [3] [1]. XX FF activator; XX IN T01673 rfx1; human, Homo sapiens. IN T01669 rfx2; mouse, Mus musculus. IN T01670 rfx3; human, Homo sapiens. IN T22484 RFXDC1; human, Homo sapiens. XX MX M00975 V$RFX_Q6. MX M07305 V$RFX_Q6_01. XX BS R02384. BS R03695. BS R01940. BS R02241. XX DR TRANSPATH: MO000025855. DR UniProtKB: P48380; XX RN [1]; RE0003800. RX PUBMED: 8289803. RA Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B. RT RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins RL Mol. Cell. Biol. 14:1230-1244 (1994). RN [2]; RE0022520. RX PUBMED: 10706293. RA Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W., Mach B., Burley S. K. RT Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. RL Nature 403:916-921 (2000). RN [3]; RE0022525. RX PUBMED: 10330134. RA Iwama A., Pan J., Zhang P., Reith W., Mach B., Tenen D. G., Sun Z. RT Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. RL Mol. Cell. Biol. 19:3940-3950 (1999). XX //