AC T01670
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ID T01670
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DT 15.02.1996 (created); ewi.
DT 19.02.2016 (updated); sup.
CO Copyright (C), QIAGEN.
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FA rfx3
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SY bA32F11.1; MGC87155; regulatory factor X, 3 (influences HLA class II expression); RFX3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004681 RFX3; HGNC: RFX3.
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CL C0023; fork head; 3.3.3.0.3.
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SF member of winged-helix class of helix-turn-helix superclass of factors [2];
SF can bind DNA as a homodimer or heterodimer with RFX1 [3];
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CP ubiquitous; highest level in testis [1]; highly expressed in primary eosinophils [3] [3] [1].
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FF activator;
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IN T01673 rfx1; human, Homo sapiens.
IN T01669 rfx2; mouse, Mus musculus.
IN T01670 rfx3; human, Homo sapiens.
IN T22484 RFXDC1; human, Homo sapiens.
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MX M00975 V$RFX_Q6.
MX M07305 V$RFX_Q6_01.
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BS R02384.
BS R03695.
BS R01940.
BS R02241.
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DR TRANSPATH: MO000025855.
DR UniProtKB: P48380;
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RN [1]; RE0003800.
RX PUBMED: 8289803.
RA Reith W., Ucla C., Barras E., Gaud A., Durand B., Herrero-Sanchez C., Kobr M., Mach B.
RT RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins
RL Mol. Cell. Biol. 14:1230-1244 (1994).
RN [2]; RE0022520.
RX PUBMED: 10706293.
RA Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W., Mach B., Burley S. K.
RT Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
RL Nature 403:916-921 (2000).
RN [3]; RE0022525.
RX PUBMED: 10330134.
RA Iwama A., Pan J., Zhang P., Reith W., Mach B., Tenen D. G., Sun Z.
RT Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.
RL Mol. Cell. Biol. 19:3940-3950 (1999).
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