AC T01689
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ID T01689
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DT 22.02.1996 (created); ewi.
DT 21.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Staf-50
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SY GPSTAF50; RNF94; STAF50; stimulated trans-acting factor of 50 kDa; stimulated transacting factor of 50 kDa; TRIM22; tripartite motif containing 22; tripartite motif-containing 22.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002737 TRIM22; HGNC: TRIM22.
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CL C0049; RING.
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SF sequences and arrangement of RING finger, IM and the zinc finger-like motifs are conserved among Staf-50, Rpt-1, SS-A/RO and RFP [1];
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CP ubiquitous, varying levels [1].
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FF repressor (at HIV-1 LTR) [1];
FF considerable basal expression, strongly induced by IFN-gamma and -alpha/beta over 16h [1];
FF transcription of Staf50 gene is positively regulated by wt p53 [2];
FF antiproliferative effects [2];
FF induces differentiation of U937 leukemic cells [2];
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IN T22414 atrophin-2; human, Homo sapiens.
IN T19876 CIC; human, Homo sapiens.
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DR TRANSPATH: MO000025871.
DR UniProtKB: Q8IYM9;
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RN [1]; RE0003822.
RX PUBMED: 7797467.
RA Tissot C., Mechti N.
RT Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression
RL J. Biol. Chem. 270:14891-14898 (1995).
RN [2]; RE0025427.
RX PUBMED: 15064739.
RA Obad S., Brunnstrom H., Vallon-Christersson J., Borg A., Drott K., Gullberg U.
RT Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells.
RL Oncogene 23:4050-4059 (2004).
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