AC T01730
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ID T01730
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DT 11.03.1996 (created); ewi.
DT 05.12.2007 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA HOXB5
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SY Ghox-2.1 (chick); homeo box B5; Hox2.1; HOX2A; XHox-1B (Xenopus); Xlhbox4 (Xenopus).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009913 HOXB5; HGNC: HOXB5.
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HO Scr (Drosophila).
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CL C0006; homeo; 3.1.1.5.2.
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SF binds to tandem repeats with at least 100-fold higher affinity than to single sites [2];
SF for cooperative binding, a small region is required that is N-terminally adjacent to the homeodomain [2];
SF cooperativity is enhanced upon oxidation of Cys-232 (between homeo domain helices 2 and 3) [2];
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CP Expressed in melanocyte and melanoma cell lines like A375, Me1559, Me665/1, Me4405, Me1042/R, Me9742/2, Me3146, FM713, FM727 and NT2/D1 [7].
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FF HOXB5 expression may be a prerequisite for cellular infection by HCMV, i. e. for expression of viral IE genes [6];
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MX M01319 V$HOXB5_01.
MX M04349 V$HOXB5_03.
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BS R73590.
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DR TRANSPATH: MO000046017.
DR UniProtKB: P09067; HXB5_HUMAN.
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RN [1]; RE0003886.
RX PUBMED: 2576652.
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
RT Organization of human class I homeobox genes
RL Genome 31:745-756 (1989).
RN [2]; RE0003911.
RX PUBMED: 8101633.
RA Galang C. K., Hauser C. A.
RT Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro
RL Mol. Cell. Biol. 13:4609-4617 (1993).
RN [3]; RE0003942.
RX PUBMED: 1355360.
RA Galang C. K., Hauser C. A.
RT Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product
RL New Biol. 4:558-568 (1992).
RN [4]; RE0003946.
RX PUBMED: 3453105.
RA Simeone A., Mavilio F., Bottero L., Giampaolo A., Russo G., Faiella A., Boncinelli E., Peschle C.
RT A human homoeo box gene specifically expressed in spinal cord during embryonic development
RL Nature 320:763-765 (1986).
RN [5]; RE0003948.
RX PUBMED: 4075393.
RA Hauser C. A., Joyner A. L., Klein R. D., Learned T. K., Martin G. R., Tjian R.
RT Expression of homologous homeo box containing genes in differentiated human teratocarcinoma cells and mouse embryos
RL Cell 43:19-28 (1985).
RN [6]; RE0003952.
RX PUBMED: 1353108.
RA Kadota C., Nagahama M., Tsutsui Y.
RT Relationship between HOX2 homeobox gene expression and the human cytomegalovirus immediate early genes
RL J. Gen. Virol. 73:975-981 (1992).
RN [7]; RE0012439.
RX PUBMED: 8756643.
RA Care A., Silvani A., Meccia E., Mattia G., Stoppacciaro A., Parmiani G., Peschle C., Colombo M. P.
RT HOXB7 constitutively activates basic fibroblast growth factor in melanomas
RL Mol. Cell. Biol. 16:4842-4851 (1996).
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