AC T01760
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ID T01760
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DT 17.04.1996 (created); ewi.
DT 23.02.2005 (updated); elf.
CO Copyright (C), QIAGEN.
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FA HOXD11
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SY homeo box D11; Hox-4.6; Hox-5.4; Hox-5.5; HOX4F (human); Hoxd-11; HOXD11.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014504 Hoxd11.
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HO Abd-B (Drosophila).
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CL C0006; homeo.
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SZ 323 AA; 33.5 kDa (cDNA) (calc.).
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SQ MYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKW
SQ PYRGGGGGGAGGGGGGGPGGGGGGSGGYAPYYAAAAAAAAAAAAAEEAAMQRDLLPPAGR
SQ RPDVLFKAPEPVCGAPGPPHGPAAAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQP
SQ QPAPAPPQPEGAADKGDPKPGAGGGGGSPCAKATPGPEPKGAAEGGGGEGEGPPGEAGAE
SQ KSGGTVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQ
SQ NRRMKEKKLNRDRLQYFTGNPLF
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SC Swiss-Prot#P23813
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FT 249 309 
PS50071; HOMEOBOX_2.
FT 251 313 
SM00389; HOX_1.
FT 252 308 
PF00046; Homeobox domain.
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FF expressed in posterior parts of the developing embryo [2];
FF expressed in the distal domains of developing limb [1];
FF part of the cranio-caudal sequential expression pattern of the HOX gene clusters [2];
FF required for development of radius and ulna as well as for normal kidney development (together with HoxA11) [4];
FF a bipartite control domain in the 3'-flanking region comprises a general enhancer and a restricting domain, the latter governing the proper expression pattern [3];
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MX M01434 V$HOXD11_01.
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DR TRANSPATH: MO000046064.
DR EMBL: X60761; MMHOX46E1.
DR EMBL: X60762; MMHOX46E2.
DR EMBL: X71422; MMHOXD11.
DR UniProtKB: P23813; HXDB_MOUSE.
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RN [1]; RE0004062.
RX PUBMED: 2574828.
RA Dolle P., Izpisua-Belmonte J.-C., Falkenstein H., Renucci A., Duboule D.
RT Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation
RL Nature 342:767-772 (1989).
RN [2]; RE0004073.
RX PUBMED: 1676674.
RA Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.
RT Murine genes related to the Drosophila AbdB homeotic gene are sequentially expressed during development of the posterior part of the body
RL EMBO J. 10:2279-2289 (1991).
RN [3]; RE0004074.
RX PUBMED: 7902810.
RA Gerard M., Duboule D., Zakany J.
RT Structure and activity of regulatory elements involved in the activation of Hoxd-11 gene during late gastrulation
RL EMBO J. 12:3539-3550 (1993).
RN [4]; RE0006760.
RX PUBMED: 7596412.
RA Davis A. P., Witte D. P., Hsieh-Li H. M., Potter S. S., Capecchi M. R.
RT Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11
RL Nature 375:791-795 (1995).
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