AC T01794
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ID T01794
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DT 06.05.1996 (created); ewi.
DT 02.04.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA INSAF
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SY IEF-1; insulin activator factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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CL C0010; bHLH.
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SF potential phosphorylation sites for PKA, PKC, CaMKII, glycogen synthase kinase 3, tyrosine kinases [2];
SF functional heterodimers with E12 [2];
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CP pancreatic alpha and beta cells.
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FF activator of the insulin enhancer control element in insulin expressing cells [2];
FF negatively regulated by Id [2];
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IN T00204 E12; human, Homo sapiens.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
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DR TRANSPATH: MO000025931.
DR UniProtKB: Q16219;
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RN [1]; RE0001479.
RX PUBMED: 1996108.
RA Leshkowitz D., Walker M. D.
RT Extinction of insulin gene expression in hybrids between beta cells and fibroblasts is accompanied by loss of the putative beta-cell-specific transcription factor IEF1
RL Mol. Cell. Biol. 11:1547-1552 (1991).
RN [2]; RE0004052.
RX PUBMED: 7935390.
RA Robinson G. L. W., Cordle S. R., Henderson E., Weil P. A., Teitelman G., Stein R.
RT Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expression
RL Mol. Cell. Biol. 14:6704-6714 (1994).
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