AC T01822
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ID T01822
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DT 17.05.1996 (created); ewi.
DT 04.06.2009 (updated); apk.
CO Copyright (C), QIAGEN.
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FA Pax-2b
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SY mPax-2; mPax2; paired box gene 2; Pax-2; PAX2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006530 Pax2.
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CL C0017; paired.
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SZ 390 AA; 42.0 kDa (gene) (calc.), 46 kDa (SDS)
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SQ MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS
SQ HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAE
SQ GICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDP
SQ VGSYSINGILGIPRSNGEKRKREVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDR
SQ VFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASANPELGSNVSGTQTYP
SQ VVTGRDMTSTTLPGYPPHLPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRF
SQ SNPALLSSPYYYSAAPRSAPAARAAAYDRH
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SC edited Swiss-Prot #P32114
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FT 15 139 
PF00292; 'Paired box' domain.
FT 15 139 
SM00351; pax3.
FT 15 141 
PS51057; PAIRED_2.
FT 68 370 
PF00478; IMP dehydrogenase / GMP reductase domain.
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SF a splice variant is Pax-2a [1];
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CP condensing mesenchyme cells & their epithelial derivatives in the developing kidney [1].
EX kidney (right and left),embryonic (E16,TS24) cells from kidney,,Theiler Stage 24; high; Western blot; protein; [3].
EX liver,embryonic (E16, TS24) cells from liver,,Theiler Stage 24; none; Western blot; protein; [3].
EX spinal cord,embryonic (E16,TS24) cells from neural tube,,Theiler Stage 24; low; immunoprecipitation; protein; [3].
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FF active during mesenchyme-to-epithelium transition in early kidney development [1];
FF overexpressed in Wilms tumor [1];
FF oncogenic potential [2];
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IN T05686 Grg4; mouse, Mus musculus.
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MX M00098 V$PAX2_01.
MX M00486 V$PAX2_02.
MX M03839 V$PAX2_Q2.
MX M00808 V$PAX_Q6.
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BS R02801.
BS R16788.
BS R20634.
BS R08703.
BS R25062.
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DR TRANSPATH: MO000025956.
DR UniProtKB: P32114;
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RN [1]; RE0002828.
RX PUBMED: 1311084.
RA Dressler G. R., Douglass E. C.
RT Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor
RL Proc. Natl. Acad. Sci. USA 89:1179-1183 (1992).
RN [2]; RE0004244.
RX PUBMED: 8099544.
RA Maulbecker C. C., Gruss P.
RT The oncogenic potential of Pax genes
RL EMBO J. 12:2361-2367 (1993).
RN [3]; RE0023318.
RX PUBMED: 14532124.
RA Cai Y., Brophy P. D., Levitan I., Stifani S., Dressler G. R.
RT Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation.
RL EMBO J. 22:5522-5529 (2003).
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//