AC T01865
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ID T01865
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DT 05.08.1996 (created); ewi.
DT 10.08.2006 (updated); jul.
CO Copyright (C), QIAGEN.
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FA Oct-2.3
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SY Oct-2; Oct2a; Oct2b; OTF-2; OTF2; POU domain, class 2, transcription factor 2; POU2F2; POU2F2 (Oct-2.3).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009189 Pou2f2.
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CL C0007; POU.
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SZ 485 AA; 51.8 kDa (cDNA) (calc.).
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SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS
SQ TKVGILSGLHLTFWGPGPCLSPPQIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQ
SQ LAGDIQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTS
SQ QPRAGLPTQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN
SQ DFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLP
SQ GRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR
SQ INPCSAAPMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSR
SQ TAGGGGGGGGRALPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSAGPGLWWNP
SQ APYQP
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SC translated from EMBL #X57938
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FT 201 275 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 201 275 
SM00352; pou.
FT 301 361 
PS50071; HOMEOBOX_2.
FT 301 363 
PS50550; POU_HOMEODOMAIN.
FT 303 365 
SM00389; HOX_1.
FT 304 360 
PF00046; Homeobox domain.
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SF at least six splice variants known: Oct-2.1, Oct-2/Oct-2A/Oct-2.2, Oct-2.3, Oct-2.4, Oct-2B/Oct-2.5, and Oct-2.6 [2];
SF the glutamine-rich region acts as trans-activation domain through proximal octamer elements exclusively [4];
SF the Oct-2.3-specific insert of 22 AA residues (63-84) acts as a negative regulatory domain (NRD) onto the adjacent glutamine-rich trans-activation domain [4];
SF the C-terminal, proline-rich trans-activation domain depends on additional B-cell specific factors [4];
SF this domain varies among alternative splice products [3] [2];
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IN T00643 POU2F1; rat, Rattus norvegicus.
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MX M01368 V$OCT2_01.
MX M03836 V$OCT2_Q6.
MX M00210 V$OCT_C.
MX M00795 V$OCT_Q6.
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BS R01176.
BS R03333.
BS R03334.
BS R03335.
BS R00841.
BS R00870.
BS R01884.
BS R03426.
BS R02226.
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DR TRANSPATH: MO000025987.
DR EMBL: X57938;
DR UniProtKB: Q00196-3;
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RN [1]; RE0000423.
RX PUBMED: 2573523.
RA Schoeler H. R., Hatzopoulos A. K., Balling R., Suzuki N., Gruss P.
RT A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor
RL EMBO J. 8:2543-2550 (1989).
RN [2]; RE0002095.
RX PUBMED: 2011512.
RA Wirth T., Priess A., Annweiler A., Zwilling S., Oeler B.
RT Multiple Oct2 isoforms are generated by alternative splicing
RL Nucleic Acids Res. 19:43-51 (1991).
RN [3]; RE0004288.
RX PUBMED: 1281152.
RA Lillycrop K. A., Latchman D. S.
RT Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters
RL J. Biol. Chem. 267:24960-24965 (1992).
RN [4]; RE0004292.
RX PUBMED: 7937153.
RA Annweiler A., Zwilling S., Wirth T.
RT Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms
RL Nucleic Acids Res. 22:4250-4258 (1994).
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