AC T01888
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ID T01888
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DT 09.08.1996 (created); ewi.
DT 19.11.2007 (updated); pch.
CO Copyright (C), QIAGEN.
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FA POU6F1 (c2)
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SY Brain-5 (c2); Brn-5 (c2); Emb (c2).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002475 Pou6f1.
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CL C0007; POU.
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SZ 301 AA; 32.8 kDa (calc.), 32.9 kDa (m)
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SQ MPGISSQILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLA
SQ SSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPITCS
SQ ETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAY
SQ SQSAICRFEKLDITPKSAQKLKPVLEKWLMEAELRNQEGQQNLMEFVGGEPSKKRKRRTS
SQ FTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTSKLNVFQI
SQ P
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SC translated from EMBL #D13801
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FT 139 213 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 139 213 
SM00352; pou.
FT 232 292 
PS50071; HOMEOBOX_2.
FT 232 294 
PS50550; POU_HOMEODOMAIN.
FT 234 296 
SM00389; HOX_1.
FT 235 291 
PF00046; Homeobox domain.
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SF at least four additional alternative splice products: POU6F1 c1, c5, c6, and c7, the last being a testis-specific variant in which a distinct 5'-UTR and thus another translation initiation region has been fused directly to the POU domain [4];
SF splice variants c3 and c4 differ from c2 only in the 5' UTR region and thus encode identical proteins [1];
SF binding consensus is very similar to Brn-3 proteins (POU4 group) [3];
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CP (E15.5-16.5:) laminar region of forebrain cortex, mitral region of olfactory bulb, (adult:) brain, mitral cell layer of olfactory bulb, pyramidal cell layer of hippocampus, granule cell layer of cerebellum and cortex, kidney, skeletal muscle [1] [2].
CN (adult:) gut heart, liver [1].
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FF may play a role in specifying a subset of neurons [2];
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MX M00465 V$POU6F1_01.
MX M01462 V$POU6F1_02.
MX M01479 V$POU6F1_03.
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BS R10715.
BS R10716.
BS R10717.
BS R10718.
BS R10719.
BS R10720.
BS R10721.
BS R10722.
BS R10723.
BS R10724.
BS R10725.
BS R10726.
BS R10727.
BS R10728.
BS R10729.
BS R10730.
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DR TRANSPATH: MO000026005.
DR EMBL: D13801;
DR UniProtKB: Q07916-1;
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RN [1]; RE0004419.
RX PUBMED: 8463278.
RA Okamoto K., Wakamiya M., Noji S., Koyama E., Taniguchi S., Takemura R., Copeland N. G., Gilbert D. J., Jenkins N. A., Muramatsu M., Hamada H.
RT A novel class of murine POU gene predominantly expressed in central nervous system
RL J. Biol. Chem. 268:7449-7457 (1993).
RN [2]; RE0008988.
RX PUBMED: 7908264.
RA Wey E., Lyons G. E., Schaefer B. W.
RT A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues
RL Eur. J. Biochem. 220:753-762 (1994).
RN [3]; RE0016787.
RX PUBMED: 9852081.
RA Rhee J. M., Gruber C. A., Brodie T. B., Trieu M., Turner E. E.
RT Highly cooperative homodimerization is a conserved property of neural POU proteins
RL J. Biol. Chem. 273:34196-34205 (1998).
RN [4]; RE0000312.
RX PUBMED: 3023048.
RA Moncollin V., Miyamoto N. G., Zheng X. M., Egly J. M.
RT Identification of a factor specific for the upstream element of the adenovirus-2 major late promoter
RL EMBO J. 5:2577-2584 (1986).
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