AC T01949
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ID T01949
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DT 18.11.1996 (created); ewi.
DT 22.01.2016 (updated); sla.
CO Copyright (C), QIAGEN.
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FA NFATc3
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SY NF-AT4; NF-ATc3; NFAT4; NFATx.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005449 Nfatc3.
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CL C0052; REL/NFAT; 6.1.3.0.3.
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CP high levels in thymus, spleen, medium levels in colon, heart, kidney, lung, pancreas, stomach, testis, low in brain, skin [1]; smooth muscle cells of cerebral arteries, thymus [2] [3] [2] [3] [1].
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FF activator, may contribute to activation through the distal NF-AT site of the IL-2 gene [1];
FF not part of the NF-AT complex at this site formed in thymus, spleen, lymph nodes [1];
FF phosphorylated in response to enhanced intracellular calcium levels or to PKC activation [1];
FF nuclear export is regulated by JNK2 in smooth muscle cells [2];
FF nuclear export is constitutively elevated and depends on exportin Crm-1 in smooth muscle cells [2];
FF UTP, uridine triphosphate, leads to nuclear accumulation of NFATc3 by inhibiting JNK2 activity in smooth muscle cells [2] [3];
FF predominant NFAT isoform expressed in smooth muscle cells of cerebral arteries [3];
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MX M01886 V$NFAT4_Q3.
MX M07607 V$NFAT4_Q5.
MX M00935 V$NFAT_Q4_01.
MX M00302 V$NFAT_Q6.
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BS R29840.
BS R68037.
BS R68040.
BS R13418.
BS R13429.
BS R34140.
BS R68041.
BS R68042.
BS R68043.
BS R14475.
BS R64826.
BS R30122.
BS R31309.
BS R31310.
BS R72070.
BS R72275.
BS R73137.
BS R56565.
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DR TRANSPATH: MO000026045.
DR UniProtKB: P97305; NFC3_MOUSE.
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RN [1]; RE0004634.
RX PUBMED: 7650004.
RA Ho S. N., Thomas D. J., Timmerman L. A., Li X., Francke U., Crabtree G. R.
RT NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity
RL J. Biol. Chem. 270:19898-19907 (1995).
RN [2]; RE0023856.
RX PUBMED: 12954637.
RA Gomez M. F., Bosc L. V., Stevenson A. S., Wilkerson M. K., Hill-Eubanks D. C., Nelson M. T.
RT Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1.
RL J. Biol. Chem. 278:46847-46853 (2003).
RN [3]; RE0023862.
RX PUBMED: 12145283.
RA Gomez M. F., Stevenson A. S., Bonev A. D., Hill-Eubanks D. C., Nelson M. T.
RT Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle.
RL J. Biol. Chem. 277:37756-37764 (2002).
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