TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01949 XX ID T01949 XX DT 18.11.1996 (created); ewi. DT 22.01.2016 (updated); sla. CO Copyright (C), QIAGEN. XX FA NFATc3 XX SY NF-AT4; NF-ATc3; NFAT4; NFATx. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005449 Nfatc3. XX CL C0052; REL/NFAT; XX CP high levels in thymus, spleen, medium levels in colon, heart, kidney, lung, pancreas, stomach, testis, low in brain, skin [1]; smooth muscle cells of cerebral arteries, thymus [2] [3] [2] [3] [1]. XX FF activator, may contribute to activation through the distal NF-AT site of the IL-2 gene [1]; FF not part of the NF-AT complex at this site formed in thymus, spleen, lymph nodes [1]; FF phosphorylated in response to enhanced intracellular calcium levels or to PKC activation [1]; FF nuclear export is regulated by JNK2 in smooth muscle cells [2]; FF nuclear export is constitutively elevated and depends on exportin Crm-1 in smooth muscle cells [2]; FF UTP, uridine triphosphate, leads to nuclear accumulation of NFATc3 by inhibiting JNK2 activity in smooth muscle cells [2] [3]; FF predominant NFAT isoform expressed in smooth muscle cells of cerebral arteries [3]; XX MX M01886 V$NFAT4_Q3. MX M07607 V$NFAT4_Q5. MX M00935 V$NFAT_Q4_01. MX M00302 V$NFAT_Q6. XX BS R29840. BS R68037. BS R68040. BS R13418. BS R13429. BS R34140. BS R68041. BS R68042. BS R68043. BS R14475. BS R64826. BS R30122. BS R31309. BS R31310. BS R72070. BS R72275. BS R73137. BS R56565. XX DR TRANSPATH: MO000026045. DR UniProtKB: P97305; NFC3_MOUSE. XX RN [1]; RE0004634. RX PUBMED: 7650004. RA Ho S. N., Thomas D. J., Timmerman L. A., Li X., Francke U., Crabtree G. R. RT NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity RL J. Biol. Chem. 270:19898-19907 (1995). RN [2]; RE0023856. RX PUBMED: 12954637. RA Gomez M. F., Bosc L. V., Stevenson A. S., Wilkerson M. K., Hill-Eubanks D. C., Nelson M. T. RT Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1. RL J. Biol. Chem. 278:46847-46853 (2003). RN [3]; RE0023862. RX PUBMED: 12145283. RA Gomez M. F., Stevenson A. S., Bonev A. D., Hill-Eubanks D. C., Nelson M. T. RT Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle. RL J. Biol. Chem. 277:37756-37764 (2002). XX //