AC T01958
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ID T01958
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DT 20.11.1996 (created); ewi.
DT 06.02.2001 (updated); rio.
CO Copyright (C), QIAGEN.
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FA Lmx1
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SY Lmx-1; Lmx1.1.
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OS golden (Syrian) hamster, Mesocricetus auratus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; cricetidae; cricetinae; cricetini
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CL C0025; LIM-homeo.
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SZ 382 AA; 42.8 kDa (cDNA) (calc.).
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SQ MLDGLKMEENFQSAIETSASFSSLLGRAVSPKSVCEGCQRVISDRFLLRLNDSFWHEQCV
SQ QCASCKEPLETTCFYRDKKLYCKYHYEKLFAVKCGGCFEAIAPNEFVMRAQKSVYHLSCF
SQ CCCVCERQLQKGDEFVLKEGQLLCKGDYEKERELLSLVSPAASDSGKSDDEESLCKSAHG
SQ AGKGTSEDGKDHKRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQ
SQ VWFQNQRAKMKKLARRQQQQQQDQQNTQRLSSAQTNGGGTAGMEGIMNPYTAMPTPQQLL
SQ AIEQSVYNADPFRQGLTPPQMPGDHMHPYGAEPLFHDLDSDDTSLSNLGDCFLATSEAGP
SQ LQSRVGNPIDHLYSMQNSYFTS
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SC Swiss-Prot#Q04650
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FT 33 92 
PS50023; LIM_DOMAIN_2.
FT 34 85 
SM00132; lim_4.
FT 35 91 
PF00412; LIM domain.
FT 93 147 
SM00132; lim_4.
FT 93 154 
PS50023; LIM_DOMAIN_2.
FT 94 153 
PF00412; LIM domain.
FT 193 253 
PS50071; HOMEOBOX_2.
FT 195 257 
SM00389; HOX_1.
FT 196 252 
PF00046; Homeobox domain.
FT 196 252 
PS50558; LIM_HOMEODOMAIN.
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SF very similar DNA-binding specificity as Cdx-3 [1];
SF LIM domains mediate synergistic function with E47 [1];
SF cannot be replaced by LIM domains of Isl-1 [1];
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CP insulin-producing insulinoma cell line, islet cells (protein) [1].
CN brain, liver, whole pancreas, testis [1].
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FF activator of the insulin gene, synergistically operating with E47/Pan-1 [1];
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MX M01409 V$LMX1_01.
MX M07386 V$LMX1_Q2.
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BS R08851.
BS R08849.
BS R08850.
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DR TRANSPATH: MO000045994.
DR TRANSCOMPEL: C00036.
DR EMBL: X81406; MALMX.
DR UniProtKB: Q04650; LMX1_MESAU.
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RN [1]; RE0004765.
RX PUBMED: 1358758.
RA German M. S., Wang J., Chadwick R. B., Rutter W. J.
RT Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex
RL Genes Dev. 6:2165-2176 (1992).
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