AC T02004
XX
ID T02004
XX
DT 13.12.1996 (created); ewi.
DT 09.03.2005 (updated); elf.
CO Copyright (C), QIAGEN.
XX
FA Cut
XX
SY CT.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
HO Clox (dog), CDP (human), Cux (mouse).
XX
CL C0006; homeo.
XX
SZ 2175 AA; 233.6 kDa (cDNA) (calc.).
XX
SQ MQPTLPQAAGTADMDLTAVQSINDWFFKKEQIYLLAQFWQQRATLAEKEVNTLKEQLSTG
SQ NPDSNLNSENSDTAAAAATAAAVAAVVAGATATNDIEDEQQQQLQQTASGGILESDSDKL
SQ LNSSIVAAAITLQQQNGSNLLANTNTPSPSPPLLSAEQQQQLQSSLQQSGGVGGACLNPK
SQ LFFNHAQQMMMMEAAAAAAAAALQQQQQQQSPLHSPANEVAIPTEQPAATVATGAAAAAA
SQ AAATPIATGNVKSGSTTSNANHTNSNNSHQDEEELDDEEEDEEEDEDEDDEEENASMQSN
SQ ADDMELDAQQETRTEPSATTQQQHQQQDTEDLEENKDAGEASLNVSNNHNTTDSNNSCSR
SQ KNNNGGNESEQHVASSAEDDDCANNNTNTSNNNNTSNTATSNTNNNNNNNSSSGNSEKRK
SQ KKNNNNNNGQPAVLLAAKDKEIKALLDELQRLRAQEQTHLVQIQRLEEHLEVKRQHIIRL
SQ EARLDKQQINEALAEATALSAAASTNNNNNSQSSDNNKKLNTAAERPMDASSNADLPEST
SQ KAPVPAEDDEEDEDQAMLVDSEEAEDKPEDSHHDDDEDEDEDREAVNATTTDSNELKIKK
SQ EQHSPLDLNVLSPNSAIAAAAAAAAAAACANDPNKFQALLIERTKALAAEALKNGASDAL
SQ SEDAHHQQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQPNSGSNSNPASNDHHHGHHLH
SQ GHGLLHPSSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANSTAQLAASLASTLN
SQ GTKSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVAAGGDGRGHYRFAD
SQ SELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLS
SQ VHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKS
SQ LIPKKDSGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGG
SQ EDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRH
SQ DDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFE
SQ REIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSS
SQ LEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGG
SQ ASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHSTPQRP
SQ TKAVLPPITQQQFDMFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLAR
SQ PKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLA
SQ SKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQ
SQ QHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPS
SQ AGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTH
SQ DITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWL
SQ SDANNVERLQLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVG
SQ GAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRL
SQ KQQVPHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYF
SQ AAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKR
SQ ERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSS
SQ RRKPAAPQWVNPAGAVTNPSAVVAAVAAAAAAAADNERIINGVCVMQASEYGRDDTDSNK
SQ PTDGGNDSDHEHAQLEIDQRFMEPEVHIKQEEDDDEEQSGSVNLDNEDNATSEQKLKVIN
SQ EEKLRMVRVRRLSSTGGGSSEEMPAPLAPPPPPPAASSSIVSGESTTSSSSSSNTSSSTP
SQ AVTTAAATAAAGWNY
XX
SC Swiss-Prot#P10180
XX
FT 29 2110 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 877 964 
PF02376; CUT domain.
FT 877 964 
PS51042; CUT.
FT 1043 1052 
PF00904; Involucrin repeat.
FT 1194 1203 
PF00904; Involucrin repeat.
FT 1330 1417 
PF02376; CUT domain.
FT 1330 1417 
PS51042; CUT.
FT 1608 1695 
PF02376; CUT domain.
FT 1608 1695 
PS51042; CUT.
FT 1743 1803 
PS50071; HOMEOBOX_2.
FT 1744 1804 PS50560; CUT_HOMEODOMAIN.
FT 1745 1807 SM00389; HOX_1.
FT 1746 1802 PF00046; Homeobox domain.
XX
FF Cut binds directly and specifically to the major groove of the AT2 site R16492 [3];
XX
MX M02336 I$CT_01.
XX
BS R09578.
BS R16492.
BS R02507.
XX
DR TRANSPATH: MO000026084.
DR EMBL: X07985;
DR UniProtKB: P10180;
DR FLYBASE: FBgn0004198; ct.
XX
RN [1]; RE0005019.
RX PUBMED: 2996782.
RA Jack J. W.
RT Molecular organization of the cut locus of Drosophila melanogaster
RL Cell 42:869-876 (1985).
RN [2]; RE0015328.
RX PUBMED: 7902124.
RA Kalionis B., O'Farrell P. H.
RT A universal target sequence is bound in vitro by diverse homeodomains
RL Mech. Dev. 43:57-70 (1993).
RN [3]; RE0025509.
RX PUBMED: 9774673.
RA Valentine S. A., Chen G., Shandala T., Fernandez J., Mische S., Saint R., Courey A. J.
RT Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer.
RL Mol. Cell. Biol. 18:6584-6594 (1998).
XX
//