AC T02050
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ID T02050
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DT 27.01.1997 (created); ewi.
DT 21.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA NKX6B
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SY Gtx; Nkx-6.2; Nkx6.2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002718 Nkx6-2.
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CL C0006; homeo; 3.1.2.19.2.
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SF highly divergent homeo domain, not interacting with DNA sequences known to bind any of the other known homeo domain proteins [1];
SF binds to MEF-2-like sites [1];
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CP glial cells of CNS including forebrain, germ cells of testis [1].
EX cerebellum,,,adult; detectable; RNAse protection assay; total RNA; [3].
EX cerebrum,,,adult; detectable; RNAse protection assay; total RNA; [3].
EX heart,,,adult; none; RNAse protection assay; total RNA; [3].
EX kidney (right and left),,,adult; none; RNAse protection assay; total RNA; [3].
EX liver,,,adult; none; RNAse protection assay; total RNA; [3].
EX lung,,,adult; none; RNAse protection assay; total RNA; [3].
EX spleen,,,adult; none; RNAse protection assay; total RNA; [3].
EX thymus,,,adult; detectable; RNAse protection assay; total RNA; [3].
EX ventral region of neural tube,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
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FF possibly a repressor of certain serum-inducible genes [1];
FF important for function of differentiated oligodendrocytes and probably involved in the regulation of mylin-specific genes like proteolipid protein (PLP) and myelin basic protein (MBP) [3];
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MX M00489 V$NKX62_Q2.
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DR TRANSPATH: MO000026121.
DR UniProtKB: D3Z4R4;
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RN [1]; RE0005104.
RX PUBMED: 8096811.
RA Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N. A., Copeland N. G., Izumo S.
RT Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter
RL EMBO J. 12:1387-1401 (1993).
RN [2]; RE0015674.
RX PUBMED: 9533954.
RA Qiu M., Shimamura K., Sussel L., Chen S., Rubenstein J. L.
RT Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
RL Mech. Dev. 72:77-88 (1998).
RN [3]; RE0016906.
RX PUBMED: 9254678.
RA Awatramani R., Scherer S., Grinspan J., Collarini E., Skoff R., O'Hagan D., Garbern J., Kamholz J.
RT Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination
RL J. Neurosci. 17:6657-6668 (1997).
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