AC T02293
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ID T02293
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DT 24.11.1997 (created); ewi.
DT 02.04.2009 (updated); ach.
CO Copyright (C), QIAGEN.
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FA FREAC4
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SY BF-2; FKHL2; HFK-2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006085 Foxd1.
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CL C0023; fork head; 3.3.1.4.1.
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SF gene located on chromosome 13 [3];
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CP (embryonic) forebrain neuroepithelium, head mesenchyme, adrenal cortex [2]; kidney: stromal cells only [1] [1] [2].
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FF plays a dual role in the establishment of the binocular visual pathways: first, in specification of the ventrotemporal retina, acting upstream of proteins directing the ipsilateral pathway;
FF and second, in the patterning of the developing ventral diencephalon where the optic chiasm forms [6];
FF appears to control the spatially restricted Ret expression during renal development [8];
FF Foxd1-dependent signals control cellularity in the renal capsule [7];
FF transcriptionally activates placental growth factor [5];
FF required for normal kidney morphogenesis [1];
FF controls production of signals required for normal transition of induced mesenchyme into tubular epithelium [1];
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MX M00292 V$FREAC4_01.
MX M05383 V$FREAC4_03.
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DR TRANSPATH: MO000026293.
DR UniProtKB: Q61345;
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RN [1]; RE0006386.
RX PUBMED: 8666231.
RA Hatini V., Huh S. O., Herzlinger D., Soares V. C., Lai E.
RT Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2
RL Genes Dev. 10:1467-1478 (1996).
RN [2]; RE0006641.
RX PUBMED: 7815060.
RA Hatini V., Lao W., Lai E.
RT Expression of Winged Helix Genes, BF-1 and BF-2, Define Adjacent Domains within the Developing Forbrain and Retina
RL J. Neurobiol. 25:1293-1309 (1994).
RN [3]; RE0006645.
RX PUBMED: 7789972.
RA Avraham K. B., Fletcher C., Overdier D. G., Clevidence D. E., Lai E., Costa R. H., Jenkins N. A., Copeland N. G.
RT Murine Chromosomal Location of Eight Members of the Hepatocyte Nuclear Factor 3/Fork Head Winged Helix Family of Transcription Factors
RL Genomics 25:388-393 (1995).
RN [4]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [5]; RE0030774.
RX PUBMED: 13678594.
RA Zhang H., Palmer R., Gao X., Kreidberg J., Gerald W., Hsiao L., Jensen R. V., Gullans S. R., Haber D. A.
RT Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1.
RL Curr. Biol. 13:1625-9 (2003).
RN [6]; RE0035045.
RX PUBMED: 15509772.
RA Herrera E., Marcus R., Li S., Williams S. E., Erskine L., Lai E., Mason C.
RT Foxd1 is required for proper formation of the optic chiasm.
RL Dev. Suppl. 131:5727-39 (2004).
RN [7]; RE0048175.
RX PUBMED: 15634693.
RA Levinson R. S., Batourina E., Choi C., Vorontchikhina M., Kitajewski J., Mendelsohn C. L.
RT Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development.
RL Development 132:529-539 (2005).
RN [8]; RE0035537.
RX PUBMED: 14522971.
RA Fukuda N., Ichihara M., Morinaga T., Kawai K., Hayashi H., Murakumo Y., Matsuo S., Takahashi M.
RT Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.
RL J. Biol. Chem. 278:50386-50392 (2003).
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