AC T02343
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ID T02343
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DT 13.02.1998 (created); tme.
DT 06.07.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA HNF-3alpha
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SY FOXA1; Hepatocyte Nuclear Factor 3 alpha; HNF-3alpha; HNF3A.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013744 Foxa1.
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CL C0023; fork head; 3.3.1.1.1.
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SF gene located on chromosome 12 [1];
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CP (embryonic) primitive streak, floorplate, forebrain, notochord, definitive endoderm [2], visceral endoderm [5]; (adult) lung, liver, stomach, small/large intestine [4]; in situ hybridization, 16,5 dpc abundantly: epithelium of submandibular gland, bronchioles of lung, intestine / lower: hepatocytes of liver / adult kidney: collecting duct epithelium of the renal pelvis, hepatocytes of liver, epithelium of intestine / 16,5 dpc: urothelium of bladder, penile urethra, prostate gland, neuroepithelium of spinal cord, epithelium lining the intestine, anal canal [6]; Northern Blot, adult, abundantly: prostate gland, moderate: small intestine, colon, lung, liver, skeletal muscle [6] [2] [4] [5] [6].
CN ES-cells; (adult) brain, skeleton muscle, heart, fat, kidney, thymus, spleen, ovary, testis [4]; in situ hybridization, 16,5 dpc: heart, gall bladder, vertebral column, adult kidney (papilla, renal cortex) [6] [4] [6].
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MX M00724 V$HNF3ALPHA_Q6.
MX M01261 V$HNF3A_01.
MX M03827 V$HNF3A_Q6.
MX M00791 V$HNF3_Q6.
MX M01012 V$HNF3_Q6_01.
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BS R20790.
BS R26298.
BS R05084.
BS R05085.
BS R20206.
BS R33785.
BS R33787.
BS R40128.
BS R68653.
BS R73160.
BS R25805.
BS R01464.
BS R19454.
BS R26408.
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DR TRANSPATH: MO000045361.
DR UniProtKB: P35582;
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RN [1]; RE0006565.
RX PUBMED: 1612587.
RA Avraham K. B., Prezioso V. R., Chen W. S., Lai E., Sladek F. M., Zhong W., Darnell jr J. E., Jenkins N. A., Copeland N. G.
RT Murine Chromosomal Location of Four Hepatocyte-Enriched Transcription Factors: HNF-3alpha, HNF-3beta, HNF-3gamma, and HNF-4
RL Genomics 13:264-268 (1992).
RN [2]; RE0006566.
RX PUBMED: 8375339.
RA Sasaki H., Hogan B. L. M.
RT Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
RL Development 118:47-59 (1993).
RN [3]; RE0006568.
RX PUBMED: 8187630.
RA Monaghan A. P., Kaestner K. H., Grau E., Schuetz G.
RT Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm
RL Development 119:567-578 (1993).
RN [4]; RE0006573.
RX PUBMED: 8034310.
RA Kaestner K. H., Hiemisch H., Luckow B., Schuetz G.
RT The HNF-3 Gene Familiy of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution
RL Genomics 20:377-385 (1994).
RN [5]; RE0006970.
RX PUBMED: 9152011.
RA Farrington S. M., Belaoussoff M., Baron M. H.
RT Winged-Helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac
RL Mech. Dev. 62:197-211 (1997).
RN [6]; RE0016757.
RX PUBMED: 8993836.
RA Peterson R. S., Clevidence D. E., Ye H., Costa R. H.
RT Hepatocyte nuclear factor-3 alpha promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation.
RL Cell Growth Differ. 8:69-82 (1997).
RN [7]; RE0048853.
RX PUBMED: 15541382.
RA van der Sluis M., Melis M. H., Jonckheere N., Ducourouble M. P., Buller H. A., Renes I., Einerhand A. W., Van Seuningen I.
RT The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.
RL Biochem. Biophys. Res. Commun. 325:952-960 (2004).
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