AC T02351
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ID T02351
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DT 24.02.1998 (created); ili.
DT 21.05.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA WT1
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SY Wilms tumor homolog; Wt-1; WT1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006881 Wt1.
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CL C0001; CH; 2.3.3.0.21.
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SF 4 zinc fingers [2];
SF alternative spliced forms [2];
SF proline-rich region [1];
SF homology to human and rat [1] [2];
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CP adult: granulosa, decidual and Sertoli cells [3].
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FF only (-KTS) forms bind to WTE site [4];
FF affinity to a probe containing the WTE site is 30 times higher then to the Egr-1 site [4];
FF for expression in teeth, see [5];
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IN T27826 Dnmt1; mouse, Mus musculus.
IN T16154 EZH2; mouse, Mus musculus.
IN T01806 p53; mouse, Mus musculus.
IN T16059 pax-2; mouse, Mus musculus.
IN T16096 SUZ12; mouse, Mus musculus.
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MX M05599 V$WT1_02.
MX M07436 V$WT1_Q4.
MX M01118 V$WT1_Q6.
MX M02036 V$WT1_Q6_01.
MX M03893 V$WT1_Q6_02.
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BS R62993.
BS R33448.
BS R61600.
BS R37270.
BS R62021.
BS R62023.
BS R56025.
BS R56028.
BS R56031.
BS R62024.
BS R62025.
BS R62841.
BS R62848.
BS R37275.
BS R60798.
BS R67749.
BS R67750.
BS R56038.
BS R63448.
BS R65253.
BS R65254.
BS R65256.
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DR TRANSPATH: MO000026343.
DR UniProtKB: P22561;
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RN [1]; RE0006640.
RX PUBMED: 8393820.
RA Rauscher III F. J.
RT The WT1 Wilms tumor gene product: A developmentally regulated transcription factor in the kidney that functions as a tumor suppressor
RL FASEB J. 7:896-903 (1993).
RN [2]; RE0006643.
RX PUBMED: 1671709.
RA Buckler A. J., Pelletier J., Haber D. A., Glaser T., Housman D.
RT Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development
RL Mol. Biol. Cell 11:1707-1712 (1991).
RN [3]; RE0006658.
RX PUBMED: 1651275.
RA Pelletier J., Schalling M., Buckler A. J., Rogers A., Haber D. A., Housman D.
RT Expression of the Wilms' tumor gene WT1 in the murine urogenital system
RL Genes Dev. 5:1345-1356 (1991).
RN [4]; RE0006744.
RX PUBMED: 7862142.
RA Nakagama H., Heinrich G., Pelletier J., Housman D. E.
RT Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product
RL Mol. Cell. Biol. 15:1489-1498 (1995).
RN [5]; RE0014821.
RA Pekkanen M., Nieminen P., Sahlberg C., Aberg T., Thesleff I.
RT Gene expression in tooth (WWW database); URL: http://bite-it.helsinki.fi/WT1.htm
RL Internet : (1996).
RN [6]; RE0039847.
RX PUBMED: 11001926.
RA Little N. A., Hastie N. D., Davies R. C.
RT Identification of WTAP, a novel Wilms' tumour 1-associating protein
RL Hum. Mol. Genet. 9:2231-9 (2000).
RN [7]; RE0047964.
RX PUBMED: 14603255.
RA Discenza M. T., He S., Lee T. H., Chu L. L., Bolon B., Goodyer P., Eccles M., Pelletier J.
RT WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2.
RL Oncogene 22:8145-8155 (2003).
RN [8]; RE0049476.
RX PUBMED: 15520190.
RA Smolen G. A., Vassileva M. T., Wells J., Matunis M. J., Haber D. A.
RT SUMO-1 modification of the Wilms' tumor suppressor WT1.
RL Cancer Res. 64:7846-7851 (2004).
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