AC T02354
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ID T02354
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DT 25.02.1998 (created); ili.
DT 20.08.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA MTF-1
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SY metal-regulatory transcription factor 1; MTF-1; ZRF (zinc-regulatory factor).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004000 MTF1; HGNC: MTF1.
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CL C0001; CH; 2.3.3.24.1.
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SF large sequence identity to mouse MTF-1 [1];
SF acidic region as well as P-rich and S/T-rich region function as activating domains [2];
SF zinc fingers might be involved in metal inducibility [2];
SF acidic and P-rich region may contribute to full zinc responsiveness [2];
SF DNA-binding is activated by Zn, but not by Cd or Cu [3];
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CP (Namalwa cells, HeLa cells).
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FF localized to 1p32-34 [1];
FF supposed to regulate metallothionein genes [1];
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MX M01242 V$MTF1_01.
MX M01243 V$MTF1_02.
MX M04507 V$MTF1_07.
MX M00650 V$MTF1_Q4.
MX M04619 V$MTF1_Q5.
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BS R27236.
BS R33408.
BS R22112.
BS R22113.
BS R63462.
BS R34729.
BS R55723.
BS R55724.
BS R55725.
BS R55726.
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DR TRANSPATH: MO000026345.
DR UniProtKB: Q14872;
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RN [1]; RE0006649.
RX PUBMED: 8065932.
RA Brugnera E., Georgiev O., Radtke F., Heuchel R., Baker E., Sutherland G. R., Schaffner W.
RT Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1
RL Nucleic Acids Res. 22:3167- 3173 (1994).
RN [2]; RE0006724.
RX PUBMED: 7610056.
RA Radtke F., Georgiev O., Muller H.-P., Brugnera E., Schaffner W.
RT Functional domains of the heavy metal-responsive transcription regulator MTF-1
RL Nucleic Acids Res. 23:2277-2286 (1995).
RN [3]; RE0013721.
RX PUBMED: 10092847.
RA Koizumi S., Suzuki K., Ogra Y., Yamada H., Otsuka F.
RT Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene.
RL Eur. J. Biochem. 259:635-642 (1999).
RN [4]; RE0013741.
RX PUBMED: 8089141.
RA Otsuka F., Iwamatsu A., Suzuki K., Ohsawa M., Hamer D. H., Koizumi S.
RT Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein IIA gene.
RL J. Biol. Chem. 269:23700-23707 (1994).
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