AC T02357
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ID T02357
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DT 03.03.1998 (created); tme.
DT 30.05.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA TLX
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SY Mouse homolog of tailless; NR2E1; TLL.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006490 Nr2e1.
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HO tailless.
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CL C0002; CC (rec).
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SF belongs to the orphan nuclear receptors;
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CP (embryonic) days 8-18 p.c., neural epithelium of the developing forebrain; adult: brain [2]; adult brain: progenitor cells [4] [4] [2].
CN differentiated nerve cells [4].
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FF repressor [4];
FF influences the development of the forebrain (e.g. limbic system), mtll deficient mice have smaller cerebral hemispheres and are more aggressive [3];
FF TLX-expressing cells are able to self-renew, and are multipotent cells that can differentiate to different nerve cells [4];
FF TLX-null cells fail to proliferate [4];
FF repressor of astrocyte-specific genes in proliferating cells [4];
FF is essential for maintaining the proliferative state of stem cells in brain [4];
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MX M05380 V$TLX_01.
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DR TRANSPATH: MO000026347.
DR UniProtKB: Q64104;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006659.
RX PUBMED: 7720587.
RA Monaghan A. P., Grau E., Bock D., Schuetz G.
RT The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain
RL Development 121:839-853 (1995).
RN [3]; RE0006660.
RX PUBMED: 9394001.
RA Monaghan A. P., Bock D., Gass P., Schwaeger A., Wolfer D. P., Lipp H.-P., Schuetz G.
RT Defective limbic system in mice lacking the tailless gene
RL Nature 390:515-517 (1997).
RN [4]; RE0023773.
RX PUBMED: 14702088.
RA Shi Y., Chichung Lie D., Taupin P., Nakashima K., Ray J., Yu R. T., Gage F. H., Evans R. M.
RT Expression and function of orphan nuclear receptor TLX in adult neural stem cells.
RL Nature 427:78-83 (2004).
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