AC T02423
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ID T02423
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DT 29.04.1998 (created); ewi.
DT 13.09.2010 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha2
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SY hepatocyte nuclear factor 4alpha2; HNF4alpha2; NR2A1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001173 Hnf4a.
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CL C0002; CC (rec).
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SZ 465 AA; 51.8 kDa (cDNA) (calc.).
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SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLSVSALCAICGDRATG
SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA
SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCE
SQ SMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY
SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIK
SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
SQ LQEMLLGGSASDAPHTHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAAT
SQ PETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
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SC Swiss-Prot#P49698
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FT 48 119 
SM00399; c4gold.
FT 48 123 
PS51030; NUCLEAR_REC_DBD_2.
FT 49 124 
PF00105; Zinc finger, C4 type (two domains).
FT 117 377 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 180 339 
SM00430; holi.
FT 183 364 
PF00104; Ligand-binding domain of nuclear hormon.
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IN T01558 SREBP-1c; human, Homo sapiens.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M02868 V$HNF4A_02.
MX M02764 V$HNF4A_04.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R04591.
BS R02179.
BS R04454.
BS R15905.
BS R32755.
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DR TRANSPATH: MO000026409.
DR EMBL: D29015;
DR UniProtKB: P49698;
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RN [1]; RE0006830.
RX PUBMED: 7999795.
RA Hata S., Inoue T., Kosuga K., Nakashima T., Tsukamoto T., Osumi T.
RT Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4)
RL Biochim. Biophys. Acta 1260:55-61 (1995).
RN [2]; RE0051054.
RX PUBMED: 17636037.
RA Ponugoti B., Fang S., Kemper J. K.
RT Functional interaction of HNF-4 and PGC-1{alpha} in CYP7A1 regulation is inhibited by a key lipogenic activator, SREBP-1c.
RL Mol. Endocrinol. 11:2698-712 (2007).
RN [3]; RE0051638.
RX PUBMED: 10490591.
RA Sladek F. M., Ruse MD J. r., Nepomuceno L., Huang S. M., Stallcup M. R.
RT Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.
RL Mol. Cell. Biol. 19:6509-6522 (1999).
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