AC T02424
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ID T02424
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DT 29.04.1998 (created); ewi.
DT 30.03.2007 (updated); ech.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha1
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SY hepatocyte nuclear factor 4; hepatocyte nuclear factor 4alpha1; HNF-4; HNF4; NR2A1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001173 Hnf4a.
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CL C0002; CC (rec).
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SZ 455 AA; 50.6 kDa (cDNA) (calc.).
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SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLSVSALCAICGDRATG
SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA
SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCE
SQ SMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY
SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIK
SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
SQ LQEMLLGGSASDAPHTHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMSTPETPQPSPPS
SQ GSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
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SC edited Swiss-Prot #P49698
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FT 48 119 
SM00399; c4gold.
FT 48 123 
PS51030; NUCLEAR_REC_DBD_2.
FT 49 124 
PF00105; Zinc finger, C4 type (two domains).
FT 117 127 
T box [4].
FT 117 377 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 129 135 
A box, PKA phosphorylation recognition site [4].
FT 180 339 
SM00430; holi.
FT 183 364 
PF00104; Ligand-binding domain of nuclear hormon.
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CP (embryonic) visceral extraembryonic endoderm (d 7-10 pc), in the periphery of the liver (d 11.5-16 pc), meso- and metanephros of the kidney (d 10.5-birth) [3]; (adult) kidney, liver, stomach, low in intestine [2], skin [3] [2] [3].
CN bladder, brain, heart, ovary [2].
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R04591.
BS R02179.
BS R04454.
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DR TRANSPATH: MO000026410.
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RN [1]; RE0006830.
RX PUBMED: 7999795.
RA Hata S., Inoue T., Kosuga K., Nakashima T., Tsukamoto T., Osumi T.
RT Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4)
RL Biochim. Biophys. Acta 1260:55-61 (1995).
RN [2]; RE0006832.
RX PUBMED: 9421506.
RA Nakhei H., Lingott A., Lemm I., Ryffel G. U.
RT An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types
RL Nucleic Acids Res. 26:497-504 (1998).
RN [3]; RE0006914.
RX PUBMED: 7873404.
RA Taraviras S., Monaghan A. P., Schuetz G., Kesley G.
RT Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis
RL Mech. Dev. 48:67-79 (1994).
RN [4]; RE0018065.
RX PUBMED: 9234678.
RA Viollet B., Kahn A., Raymondjean M.
RT Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.
RL Mol. Cell. Biol. 17:4208-4219 (1997).
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